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Short-term hypocalo...
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Nygren, JonasKarolinska Institutet
(författare)
Short-term hypocaloric nutrition but not bed rest decrease insulin sensitivity and IGF-I bioavailability in healthy subjects : the importance of glucagon
- Artikel/kapitelEngelska1997
Förlag, utgivningsår, omfång ...
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Oxford University Press,1997
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-63878
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-63878URI
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https://doi.org/10.1016/S0899-9007(97)00335-3DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1933201URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Hyperinsulinemic, normoglycemic clamps were performed before and after 24 h of either hypocaloric nutrition or bed rest in healthy subjects. Decreased insulin sensitivity and insulin-like growth factor-I (IGF-I) bioavailibility, as measured by the serum IGF-I/insulin-like growth factor binding protein-1 (IGFBP-1) ratio, was found after fasting, whereas no metabolic changes were found after bed rest. Glucagon seems to be a key regulator of IGFBP-1 after brief hypocaloric nutrition. Hypocaloric nutrition and immobilization may add to the catabolic response to surgery and other trauma. Presently, six healthy subjects were studied before and after a 24-h period of hypocaloric nutrition (200 kcal/24 h, fast) or immobilization (bed rest) using the hyperinsulinemic (0.8 mU · kg−1 · min−1), normoglycemic (4.5 mmol/L) clamp, indirect calorimetry, and circulating levels of substrates and hormones. After fast, body weight decreased (P < 0.05), and nitrogen balance was negative (−10 ± 1 g urea nitrogen/24 h). Basal levels of free fatty acids, glucagon, and IGFBP-1 increased (P < 0.05), whereas c-peptide levels and the IGF-I/IGFBP-1 ratio decreased (P < 0.05). However, no change was found in basal levels of IGF-I or substrate oxidation. Furthermore, changes (%) in basal levels of glucagon after fast correlated to IGFBP-1 (r = 1.0, P < 0.05), whereas the suppressibility of IGFBP-1 by insulin was maintained at normal levels. During clamps, glucose infusion rates (GIR) decreased after fast (−43 ± 13%, mean ± SEM, P < 0.001). Although not significant, clamp levels of fat oxidation tended to increase and glucose oxidation tended to decrease. Levels of IGFBP-1 during clamps were higher as compared with the control clamp (P < 0.05). No adverse metabolic changes were seen after bed rest, and no change in GIR during clamps were seen as compared with the control measurement (0 ± 14%). After brief hypocaloric nutrition, insulin sensitivity is reduced, whereas IGF-I bioavailibility is reduced by an increase in levels of IGFBP-1. Glucagon seems to contribute to the increase in IGFBP-1 during these conditions.
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Thorell, AndersDepartment of Surgery, Karolinska Hospital, Stockholm, Sweden
(författare)
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Brismar, KerstinKarolinska Institutet
(författare)
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Karpe, FredrikDepartment of Gustaf V Research Institute, Karolinska Hospital, Stockholm, Sweden
(författare)
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Ljungqvist, Olle,1954-Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Surgery, Karolinska Hospital, Stockholm, Sweden(Swepub:oru)olt
(författare)
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Karolinska InstitutetDepartment of Surgery, Karolinska Hospital, Stockholm, Sweden
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Nutrition: Oxford University Press13:11-12, s. 945-9510022-31661541-6100
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Ingår i:Nutrition (Burbank, Los Angeles County, Calif.): Oxford University Press13:11-12, s. 945-9510899-9007
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