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Vitamin D C3 epimer...
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Karefylakis, Christos,1982-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Endocrinology
(författare)
Vitamin D C3 epimer in a mid-Swedish region : Analytical measurement and epidemiology
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
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Amsterdam, Netherlands :Elsevier,2018
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-64072
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-64072URI
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https://doi.org/10.1016/j.cca.2018.01.002DOI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding Agency:Örebro University ALF 2016:1 OLL-615521
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Background: The discovery of an epimeric form of 25(OH)D3 may complicate the interpretation of vitamin Dstatus. The aim of this study was to examine the prevalence and determinants of 25-hydroxy-3-epi-vitamin D3 (3- epi-25(OH)D3) in a mid-Swedish region and to investigate how the measurement of 3-epi-25(OH)D3 would affect the assessment of vitamin D status using current thresholds.Methods: We conducted a cross-sectional study of 8286 in- and outpatients in primary as well as secondary care settings. Plasma 25(OH)D, 25(OH)D2, 25(OH)D3 and 3-epi-25(OH)D3 were measured using High Pressure Liquid Chromatography – Tandem Mass Spectrometry (HPLC – MS/MS). The relative 3-epi-25(OH)D3 contribution was calculated as a percentage of the total 25(OH)D3. Blood samples were collected between March 2014 and July 2015 providing a seasonal aspect to the results.Results: 3-epi-25(OH)D3was detected in 635 cases (7.7% of all subjects), and the mean concentration was8.4 ± 3.5 nmol/L. 3-epi-25(OH)D3correlated significantly with 25(OH)D3(r =0.38, p < 0.001).A multivariateanalysis among the detected showed that male gender and winter season were independently associatedwith higher 3-epi-25(OH)D3/25(OH)D3percentage ratio (R2=0.044). Infants and children had a significantlyhigher detection rate compared to the reference age category (18–45 years) as well as those who were testedduring the summer season.Conclusions: We report findings from the first epidemiologic study of 3-epi-25(OH)D3 conducted in Sweden, based on a large population sample. 3-epi-25(OH)D3 was detected in 7.7% of the study population and the mean concentration was 8.4 nmol/L. The quantification of 3-epi-25(OH)D3 would not significantly influence the clinical interpretation of vitamin D levels. Additional studies are needed to understand the metabolic pathway and the possible physiological functions of this metabolite.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Pettersson-Pablo, Paul,1986-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Clinical Chemistry, Örebro University Hospital, Örebro, Sweden(Swepub:oru)ppo
(författare)
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Särnblad, Stefan,1963-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Pediatrics(Swepub:oru)snsd
(författare)
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Rask, Eva,1958-Department of Endocrinology, School of Medical Sciences, Örebro University, Örebro, Sweden(Swepub:oru)erk
(författare)
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Bitar, ManarDepartment of Clinical Chemistry, Örebro University Hospital, Örebro, Sweden
(författare)
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Magnusson, AndersClinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden
(författare)
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Eriksson, Clas-GöranDepartment of Clinical Chemistry, Örebro University Hospital, Örebro, Sweden
(författare)
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Örebro universitetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Clinica Chimica ActaAmsterdam, Netherlands : Elsevier478, s. 182-1870009-89811873-3492
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