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Sökning: (WFRF:(Wang Gang)) srt2:(2015-2019) lar1:(oru) > RBBP6 increases rad...

  • Xiao, ChaoDepartment of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China (författare)

RBBP6 increases radioresistance and serves as a therapeutic target for preoperative radiotherapy in colorectal cancer

  • Artikel/kapitelEngelska2018

Förlag, utgivningsår, omfång ...

  • 2018-03-10
  • Blackwell Publishing,2018
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-64711
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-64711URI
  • https://doi.org/10.1111/cas.13516DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Radiotherapy (RT) can be used as preoperative treatment to downstage initially unresectable locally rectal carcinoma, but the radioresistance and recurrence remain significant problems. Retinoblastoma binding protein 6 (RBBP6) has been implicated in the regulation of cell cycle, apoptosis and chemoresistance both in vitro and in vivo. This study investigated whether the inhibition of RBBP6 expression would improve radiosensitivity in human colorectal cancer cells. After SW620 and HT29 cells were exposed to radiation, the levels of RBBP6 mRNA and protein increased over time in both two cells. Moreover, a significant reduction in clonogenic survival and a decrease in cell viability in parallel with an obvious increase in cell apoptosis were demonstrated in irradiated RBBP6-knockdown cells. Besides, transfection with RBBP6 shRNA improved levels of G2-M phase arrest which blocked the cells in a more radiosensitive period of the cell cycle. These observations indicated that cell cycle and apoptosis mechanisms may be connected with tumor cell survival following radiotherapy. In vivo, tumor growth rate of nude mice in RBBP6-knockdown group was significantly slower than that in other groups. These results indicated that RBBP6 overexpression could resist colorectal cancer cells against radiation by regulating cell cycle and apoptosis pathways, and inhibition of RBBP6 could enhance radiosensitivity of human colorectal cancer.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Wang, YupengDepartment of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China (författare)
  • Zheng, MiaoDepartment of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China (författare)
  • Chen, JianDepartment of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China (författare)
  • Song, GuoheDepartment of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China (författare)
  • Zhou, ZhijieDepartment of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China (författare)
  • Zhou, ChongzhiDepartment of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China (författare)
  • Sun, XingDepartment of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China (författare)
  • Zhong, LinDepartment of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China (författare)
  • Ding, ErxunDepartment of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China (författare)
  • Zhang, YiDepartment of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China (författare)
  • Yang, LiuDepartment of Obstetrics and Gynecology, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China (författare)
  • Wu, GangDepartment of General Surgery, Henan Provincial People's Hospital People's Hospital, Zhengzhou University, Zhengzhou, People's Republic of China (författare)
  • Xu, ShifengDepartment of General Surgery, Shandong Provincial Hospital Affiliated, Shandong University, Jinan, People's Republic of China (författare)
  • Zhang, Hong,1957-Örebro universitet,Institutionen för medicinska vetenskaper(Swepub:oru)hzg (författare)
  • Wang, XiaoliangDepartment of General Surgery, Shanghai General Hospital School of Medicine, Jiao Tong University, Shanghai, People's Republic of China (författare)
  • Department of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of ChinaDepartment of Obstetrics and Gynecology, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Cancer Science: Blackwell Publishing109:4, s. 1075-10871347-90321349-7006

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