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The MRPS18-2 protei...
The MRPS18-2 protein levels correlate with prostate tumor progression and it induces CXCR4-dependent migration of cancer cells
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- Mushtaq, Muhammad (författare)
- Karolinska Institutet,Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, 17177, Sweden. Muhammad.Mushtaq@ki.se
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- Jensen, Lasse, 1979- (författare)
- Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Klinisk farmakologi
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- Davidsson, Sabina, 1972- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Urology, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden,Department of Urology, Faculty of Medicine and Health, Örebro University, Örebro, 70182, Sweden
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- Grygoruk, Oleksandr V. (författare)
- Clinic Boris, 12AM. Bazhana ave, Kyiv, 02140, Ukraine
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- Andrén, Ove, 1963- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Urology, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden,Department of Urology, Faculty of Medicine and Health, Örebro University, Örebro, 70182, Sweden
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- Kashuba, Vladimir (författare)
- Karolinska Institutet,Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, 17177, Sweden; Institute of Molecular Biology and Genetics, NASU, 150 Zabolotnog str, Kyiv, 03143, Ukraine
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- Kashuba, Elena (författare)
- Karolinska Institutet,Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, 17177, Sweden. elena.kashuba@ki.se; R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NASU, 45 Vasylkivska str, Kyiv, 03022, Ukraine. elena.kashuba@ki.se
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Karolinska Institutet Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, 17177, Sweden Muhammad.Mushtaq@ki.se (creator_code:org_t)
- 2018-02-02
- 2018
- Engelska.
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Ingår i: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 8:1
- Relaterad länk:
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https://doi.org/10.1...
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https://www.nature.c...
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- We have earlier found abnormal expression of the mitochondrial ribosomal protein S18-2 (MRPS18-2, S18-2) in endometrial cancer, compared to the expression in hyperplasia and in normal endometrium. Here we report that expression of S18-2 was increased with disease progression in clinical specimens of prostate cancer (PCa). The level of induction of epithelial to mesenchymal cell transition (EMT) correlated with the expression level of S18-2 in PCa cell lines. Moreover, cells acquired increased ability of migration upon S18-2 overexpression, as was evaluated in zebrafish embryo model and in trans-well assay. We found that this is due to increased CXCR4 cell surface expression. Neutralizing CXCR4 protein or abrogating S18-2 expression in cells significantly reduced their migratory ability directed toward CXCL12. The mRNA expression of TWIST2, encoding one of transcription factors that induce EMT upon CXCR4 increase, positively correlated with the S18-2 protein level. Together, these data suggest that the S18-2 protein induces EMT through the TWIST2/E-cadherin signalling and, consequently, CXCR4-mediated migration of PCa cells.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
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