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  • Murphy, Eileen F.Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Alimentary Health Ltd., Cork, Ireland (författare)

Divergent metabolic outcomes arising from targeted manipulation of the gut microbiota in diet-induced obesity

  • Artikel/kapitelEngelska2013

Förlag, utgivningsår, omfång ...

  • 2012-02-16
  • BMJ Publishing Group Ltd,2013
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-65932
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-65932URI
  • https://doi.org/10.1136/gutjnl-2011-300705DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Erratum in Gut. 2013 Feb;62(2):226.
  • OBJECTIVE: The gut microbiota is an environmental regulator of fat storage and adiposity. Whether the microbiota represents a realistic therapeutic target for improving metabolic health is unclear. This study explored two antimicrobial strategies for their impact on metabolic abnormalities in murine diet-induced obesity: oral vancomycin and a bacteriocin-producing probiotic (Lactobacillus salivarius UCC118 Bac(+)).DESIGN: Male (7-week-old) C57BL/J6 mice (9-10/group) were fed a low-fat (lean) or a high-fat diet for 20 weeks with/without vancomycin by gavage at 2 mg/day, or with L. salivarius UCC118Bac(+) or the bacteriocin-negative derivative L. salivarius UCC118Bac(-) (each at a dose of 1×10(9) cfu/day by gavage). Compositional analysis of the microbiota was by 16S rDNA amplicon pyrosequencing.RESULTS: Analysis of the gut microbiota showed that vancomycin treatment led to significant reductions in the proportions of Firmicutes and Bacteroidetes and a dramatic increase in Proteobacteria, with no change in Actinobacteria. Vancomycin-treated high-fat-fed mice gained less weight over the intervention period despite similar caloric intake, and had lower fasting blood glucose, plasma TNFα and triglyceride levels compared with diet-induced obese controls. The bacteriocin-producing probiotic had no significant impact on the proportions of Firmicutes but resulted in a relative increase in Bacteroidetes and Proteobacteria and a decrease in Actinobacteria compared with the non-bacteriocin-producing control. No improvement in metabolic profiles was observed in probiotic-fed diet-induced obese mice.CONCLUSION: Both vancomycin and the bacteriocin-producing probiotic altered the gut microbiota in diet-induced obese mice, but in distinct ways. Only vancomycin treatment resulted in an improvement in the metabolic abnormalities associated with obesity thereby establishing that while the gut microbiota is a realistic therapeutic target, the specificity of the antimicrobial agent employed is critical.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Cotter, Paul D.Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Teagasc Food Research Centre, Fermoy, Ireland (författare)
  • Hogan, AileenAlimentary Pharmabiotic Centre, University College Cork, Cork, Ireland (författare)
  • O'Sullivan, OrlaTeagasc Food Research Centre, Fermoy, Ireland (författare)
  • Joyce, AndyAlimentary Health Ltd., Cork, Ireland (författare)
  • Fouhy, FionaTeagasc Food Research Centre, Fermoy, Ireland; Department of Microbiology, University College Cork, Cork, Ireland (författare)
  • Clarke, Siobhan F.Teagasc Food Research Centre, Fermoy, Ireland; Department of Microbiology, University College Cork, Cork, Ireland (författare)
  • Marques, Tatiana M.,1980-Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Teagasc Food Research Centre, Fermoy, Ireland(Swepub:oru)tams (författare)
  • O'Toole, Paul W.Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Department of Microbiology, University College Cork, Cork, Ireland (författare)
  • Stanton, CatherineAlimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Teagasc Food Research Centre, Fermoy, Ireland (författare)
  • Quigley, Eamonn M. M.Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Department of Medicine, University College Cork, Cork, Ireland (författare)
  • Daly, CharlieAlimentary Pharmabiotic Centre, University College Cork, Cork, Ireland (författare)
  • Ross, Paul R.Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Teagasc Food Research Centre, Fermoy, Ireland (författare)
  • O'Doherty, Robert M.Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Department of Medicine, Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh PA, USA (författare)
  • Shanahan, FergusAlimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Department of Medicine, University College Cork, Cork, Ireland (författare)
  • Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Alimentary Health Ltd., Cork, IrelandAlimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Teagasc Food Research Centre, Fermoy, Ireland (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Gut: BMJ Publishing Group Ltd62:2, s. 220-2260017-57491468-3288

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  • Gut (Sök värdpublikationen i LIBRIS)

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