Efficacy of succimer chelation of mercury at background exposures in toddlers: a randomized trial

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Cao, Yang,Associate Professor,1972-Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA; Department of Health Statistics, Faculty of Health Services, Second Military Medical University, Shanghai, China (författare)

Efficacy of succimer chelation of mercury at background exposures in toddlers : a randomized trial

Artikel/kapitelEngelska2011

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Elsevier,2011
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LIBRIS-ID:oai:DiVA.org:oru-66001
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-66001URI
https://doi.org/10.1016/j.jpeds.2010.08.036DOI

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Språk:engelska
Sammanfattning på:engelska

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OBJECTIVE: To examine whether succimer, a mercaptan compound known to reduce blood lead concentration in children, reduces blood mercury concentration.STUDY DESIGN: We used samples from a randomized clinical trial of succimer chelation for lead-exposed children. We measured mercury levels in pre-treatment samples from 767 children. We also measured mercury levels in blood samples drawn 1 week after treatment began (n = 768) and in a 20% random sample of the children who received the maximum 3 courses of treatment (n = 67). A bootstrap-based isotonic regression method was used to compare the trend with time in the difference between the adjusted mean mercury concentrations in the succimer group and that in the placebo group.RESULTS: The adjusted mean organic mercury concentration in the succimer group relative to the placebo group fell from 99% at baseline to 82% after 3 courses of treatment (P for trend = .048), but this resulted from the prevention of the age-related increase in the succimer group.CONCLUSION: Succimer chelation for low level organic mercury exposure in children has limited efficacy.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Pediatrik hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Pediatrics hsv//eng

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Chen, AiminDepartment of Environmental Health, Division of Epidemiology and Biostatistics, University of Cincinnati College of Medicine, Cincinnati, OH, USA (författare)
Jones, Robert L.Inorganic and Radiation Analytical Toxicology Branch, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA (författare)
Radcliffe, JerilynnThe Children’s Hospital of Philadelphia, and University of Pennsylvania School of Medicine, Philadelphia, PA, USA (författare)
Dietrich, Kim N.Department of Environmental Health, Division of Epidemiology and Biostatistics, University of Cincinnati College of Medicine, Cincinnati, OH, USA (författare)
Caldwell, Kathleen L.Inorganic and Radiation Analytical Toxicology Branch, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA (författare)
Peddada, ShyamalBiostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, USA (författare)
Rogan, Walter JEpidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA (författare)
Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA; Department of Health Statistics, Faculty of Health Services, Second Military Medical University, Shanghai, ChinaDepartment of Environmental Health, Division of Epidemiology and Biostatistics, University of Cincinnati College of Medicine, Cincinnati, OH, USA (creator_code:org_t)

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Ingår i:The Journal of Pediatrics: Elsevier158:3, s. 480-485.e10022-34761097-6833

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Av författaren/redakt...: Cao, Yang, Assoc ...; Chen, Aimin; Jones, Robert L.; Radcliffe, Jeril ...; Dietrich, Kim N.; Caldwell, Kathle ...; visa fler...; Peddada, Shyamal; Rogan, Walter J; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Pediatrik

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Av lärosätet: Örebro universitet

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