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Assays of different...
Assays of different aspects of haemostasis : what do they measure?
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- Tynngård, Nahreen (author)
- Linköping University, Linköping, Sweden
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- Lindahl, Tomas L. (author)
- Linköping University, Linköping, Sweden
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- Ramström, Sofia, 1973- (author)
- Linköping University, Linköping, Sweden
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(creator_code:org_t)
- 2015-02-05
- 2015
- English.
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In: Thrombosis Journal. - : BioMed Central (BMC). - 1477-9560. ; 13
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https://doi.org/10.1...
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https://thrombosisjo...
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Abstract
Subject headings
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- Haemostasis is a complex process affected by many factors including both cellular and plasma components. It is a multistep process starting with platelet adhesion to damaged endothelium and ending in clot fibrinolysis. There are several methods available to study different aspects of haemostasis including adhesion, aggregation, coagulation and fibrinolysis. This review describes the different methods, what aspects of haemostasis they measure and their limitations. Methods discussed include methods to study adhesion (e.g. PFA-100, cone and platelet(let) analyzer and perfusion chambers) and aggregation (e.g. Multiplate, VerifyNow and Plateletworks). Furthermore the principles behind viscoelastic haemostatic assays are presented as well as methods that can analyse aspects of haemostasis in plasma or platelet-rich-plasma samples (thrombin generation, overall haemostasis potential and Thrombodynamics Analyzer).
Subject headings
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
Keyword
- Coagulation
- Haemostasis
- Platelets
- Coagulation assays
- Platelet function testing
Publication and Content Type
- ref (subject category)
- for (subject category)
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