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Are self-reported g...
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Ganda Mall, John-Peter,1988-Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition Gut Brain Interactions Research Centre; Nutrition and Physical Activity Research Centre,Örebro universitet, Sweden,Örebro universitet, Institutionen för medicinska vetenskaper,Orebro Univ, Sweden; Orebro Univ, Sweden
(author)
Are self-reported gastrointestinal symptoms among older adults associated with increased intestinal permeability and psychological distress?
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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2018-03-20
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BioMed Central,2018
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printrdacarrier
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LIBRIS-ID:oai:DiVA.org:oru-66053
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-66053URI
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https://doi.org/10.1186/s12877-018-0767-6DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-45890URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:du-32553URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-147416URI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Funding Agencies:Bo Rydins stiftelse F0514 Faculty of Medicine and Health at Örebro University Diarrheal Disease Research Centre, Linköping University
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Funding Agencies|Bo Rydins stiftelse [F0514]; Knowledge Foundation [20110225]; Faculty of Medicine and Health at Orebro University; Diarrheal Disease Research Centre, Linkoping University
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BACKGROUND: Despite the substantial number of older adults suffering from gastrointestinal (GI) symptoms little is known regarding the character of these complaints and whether they are associated with an altered intestinal barrier function and psychological distress. Our aim was to explore the relationship between self-reported gut health, intestinal permeability and psychological distress among older adults.METHODS: Three study populations were included: 1) older adults with GI symptoms (n = 24), 2) a group of older adults representing the general elderly population in Sweden (n = 22) and 3) senior orienteering athletes as a potential model of healthy ageing (n = 27). Questionnaire data on gut-health, psychological distress and level of physical activity were collected. Intestinal permeability was measured by quantifying zonulin in plasma. The level of systemic and local inflammation was monitored by measuring C-reactive protein (CRP), hydrogen peroxide in plasma and calprotectin in stool samples. The relationship between biomarkers and questionnaire data in the different study populations was illustrated using a Principal Component Analysis (PCA).RESULTS: Older adults with GI symptoms displayed significantly higher levels of both zonulin and psychological distress than both general older adults and senior orienteering athletes. The PCA analysis revealed a separation between senior orienteering athletes and older adults with GI symptoms and showed an association between GI symptoms, psychological distress and zonulin.CONCLUSIONS: Older adults with GI symptoms express increased plasma levels of zonulin, which might reflect an augmented intestinal permeability. In addition, this group suffer from higher psychological distress compared to general older adults and senior orienteering athletes. This relationship was further confirmed by a PCA plot, which illustrated an association between GI symptoms, psychological distress and intestinal permeability.
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Östlund-Lagerström, Lina,1984-Department of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; Nutrition and Physical Activity Research Centre, Department of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Nutrition Gut Brain Interactions Research Centre; Nutrition and Physical Activity Research Centre,Orebro Univ, Sweden; Orebro Univ, Sweden
(author)
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Lindqvist, Carl Mårten,1979-Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition Gut Brain Interactions Research Centre,Örebro universitet, Sweden,Örebro universitet, Institutionen för medicinska vetenskaper,Orebro Univ, Sweden(Swepub:oru)melt
(author)
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Algilani, Samal,1981-Örebro universitet,Institutionen för hälsovetenskaper,Nutrition and Physical Activity Research Centre,Örebro universitet, Sweden,Örebro universitet, Institutionen för hälsovetenskaper,Orebro Univ, Sweden(Swepub:oru)slai
(author)
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Rasoal, Dara,1980-Örebro universitet,Institutionen för hälsovetenskaper,Nutrition and Physical Activity Research Centre,Örebro universitet, Sweden,Örebro universitet, Institutionen för hälsovetenskaper,Orebro Univ, Sweden(Swepub:du)dra
(author)
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Repsilber, Dirk,1971-Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition Gut Brain Interactions Research Centre,Örebro universitet, Sweden,Örebro universitet, Institutionen för medicinska vetenskaper,Orebro Univ, Sweden(Swepub:oru)drr
(author)
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Brummer, Robert Jan,1957-Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition Gut Brain Interactions Research Centre,Örebro universitet, Sweden,Örebro universitet, Institutionen för medicinska vetenskaper,Orebro Univ, Sweden(Swepub:oru)rnbr
(author)
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Keita, ÅsaLinköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten(Swepub:liu)asave24
(author)
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Schoultz, Ida,1979-Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition and Physical Activity Research Centre,Örebro universitet, Sweden,Örebro universitet, Institutionen för medicinska vetenskaper,Orebro Univ, Sweden(Swepub:oru)isz
(author)
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Örebro universitetInstitutionen för medicinska vetenskaper
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In:BMC Geriatrics: BioMed Central18:11471-2318
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