Non-digestible Polysaccharides and Intestinal Barrier Function: specific focus on its efficacy in elderly and patients with Crohn’s disease

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Ganda Mall, John-Peter,1988-Örebro universitet,Institutionen för medicinska vetenskaper (författare)

Non-digestible Polysaccharides and Intestinal Barrier Function : specific focus on its efficacy in elderly and patients with Crohn’s disease

BokEngelska2018

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Örebro :Örebro University,2018
121 s.
electronicrdacarrier

Nummerbeteckningar

LIBRIS-ID:oai:DiVA.org:oru-66055
ISBN:9789175292465
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-66055URI

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Språk:engelska
Sammanfattning på:engelska

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Ämneskategori:vet swepub-contenttype
Ämneskategori:dok swepub-publicationtype

Serie

Örebro Studies in Medicine,1652-4063 ;180

Anmärkningar

A large number of elderly suffer from gastrointestinal (GI) symptoms such as constipation and diarrhoea. The underlying mechanisms of age-acquired GI symptoms are not well studied but are necessary to clarify in order to recommend the right treatment. Non-digestible polysaccharides (NPS) are dietary fibres that could have beneficial effects on the intestinal immune system and barrier function, although their efficacy needs to be evaluated. Paper I showed that elderly with GI symptoms have significantly higher small intestinal permeability than a general elderly population, along with a stronger association to psychological distress. In Paper II we performed a randomised controlled trial with a general population of elderly that consumed either placebo, the NPS’s arabinoxylan or oat β-glucan for a period of 6 weeks. No protective effects were observed related to indomethacin-induced intestinal hyperpermeability, inflammatory markers, or self-reported health if compared to placebo. Paper III showed that stimulation with a yeast-derived β-glucan significantly attenuated Compound (C) 48/80-induced hyperpermeability in colonic biopsies from elderly with GI symptoms mounted in Ussing chambers, but not in young healthy adults. Arabinoxylan attenuated only C48/80-induced transcellular permeability in elderly but both paracellular and transcellular permeability in young healthy adults. Paper IV showed that the same yeast-derived β-glucan from paper III could cross the epithelium of ileal tissues from patients with Crohn’s disease (CD) and non-CD controls, mounted in Ussing chambers, and attenuate C48/80-induced hyperpermeability. In conclusion, we found that elderly with GI symptoms display a deteriorated barrier function and that administration of selective NPS can have beneficial effect on intestinal permeability in selective populations.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Andra medicinska och farmaceutiska grundvetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Other Basic Medicine hsv//eng
Non-digestible polysachharides
beta-glucan
arabinoxylan
barrier function
permeability
Ussing chamber
elderly
Crohn’s disease

Biuppslag (personer, institutioner, konferenser, titlar ...)

Brummer, Robert Jan,professor,1957-Örebro universitet,Institutionen för medicinska vetenskaper(Swepub:oru)rnbr (preses)
Schoultz, Ida,PhD,1979-Örebro universitet,Institutionen för medicinska vetenskaper(Swepub:oru)isz (preses)
Keita, Åsa,PhDLinköping University (preses)
Wirén, Mikael,biträdande professorLinköping University (opponent)
Örebro universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

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