Whole-Genome Sequencing of Emerging Invasive Neisseria meningitidis Serogroup W in Sweden

Eriksson, Lorraine,1990-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Laboratory Medicine, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden (författare)

Funding Agencies:Örebro County Council Research CommitteeNyckelfondenWellcome TrustEuropean Union
Invasive disease caused by Neisseria meningitidis serogroup W (MenW) has historically had a low incidence in Sweden, with an average incidence of 0.03 case/100,000 population from 1995 to 2014. In recent years, a significant increase in the incidence of MenW has been noted in Sweden, to an average incidence of 0.15 case/100,000 population in 2015 to 2016. In 2017 (1 January to 30 June), 33% of invasive meningococcal disease cases (7/21 cases) were caused by MenW. In the present study, all invasive MenW isolates from Sweden collected in 1995 to June 2017 (n = 86) were subjected to whole-genome sequencing to determine the population structure and to compare isolates from Sweden with historical and international cases. The increase of MenW in Sweden was determined to be due to isolates belonging to the South American sublineage of MenW clonal complex 11, namely, the novel U.K. 2013 lineage. This lineage was introduced in Sweden in 2013 and has since been the dominant lineage of MenW.

Hedberg, Sara ThulinDepartment of Laboratory Medicine, Örebro University Hospital, Örebro, Sweden (författare)
Jacobsson, Susanne,1974-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Laboratory Medicine, Örebro University Hospital, Örebro, Sweden(Swepub:oru)sajn (författare)
Fredlund, Hans,1952-Department of Laboratory Medicine, Örebro University Hospital, Örebro, Sweden (författare)
Mölling, PaulaDepartment of Laboratory Medicine, Örebro University Hospital, Örebro, Sweden (författare)
Stenmark, Bianca,1987-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Laboratory Medicine, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden(Swepub:oru)bats (författare)
Örebro universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

Ingår i:Journal of Clinical Microbiology: American Society for Microbiology56:40095-11371098-660X

Av författaren/redakt...: Eriksson, Lorrai ...; Hedberg, Sara Th ...; Jacobsson, Susan ...; Fredlund, Hans, ...; Mölling, Paula; Stenmark, Bianca ...

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