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Gut metabolome meet...
Gut metabolome meets microbiome : A methodological perspective to understand the relationship between host and microbe
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- Lamichhane, Santosh (author)
- Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland
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- Sen, Partho (author)
- Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland
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- Dickens, Alex M. (author)
- Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland
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- Oresic, Matej, 1967- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland
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- Bertram, Hanne Christine (author)
- Department of Food Science, Aarhus University, Aarslev, Denmark
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(creator_code:org_t)
- Academic Press, 2018
- 2018
- English.
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In: Methods. - : Academic Press. - 1046-2023 .- 1095-9130. ; 149, s. 3-12
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- It is well established that gut microbes and their metabolic products regulate host metabolism. The interactions between the host and its gut microbiota are highly dynamic and complex. In this review we present and discuss the metabolomic strategies to study the gut microbial ecosystem. We highlight the metabolic profiling approaches to study faecal samples aimed at deciphering the metabolic product derived from gut microbiota. We also discuss how metabolomics data can be integrated with metagenomics data derived from gut microbiota and how such approaches may lead to better understanding of the microbial functions. Finally, the emerging approaches of genome-scale metabolic modelling to study microbial co-metabolism and host-microbe interactions are highlighted.
Subject headings
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- Faecal metabolites
- Genome-scale metabolic models
- Gut microbiota
- Metabolomics
- Microbiome
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