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Sökning: WFRF:(Pedersen Marianne Giortz) > (2018) > A Genetic Investiga...

  • Martin, JoannaKarolinska Institutet (författare)

A Genetic Investigation of Sex Bias in the Prevalence of Attention-Deficit/Hyperactivity Disorder

  • Artikel/kapitelEngelska2018

Förlag, utgivningsår, omfång ...

  • Elsevier,2018
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-67268
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-67268URI
  • https://doi.org/10.1016/j.biopsych.2017.11.026DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:138332575URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies:National Human Genome Research Institute of the National Institutes of Health (NIH)  R44HG006981 Wellcome Trust  106047 Australian National Health and Medical Research Council  1078901  1087889 Stanley Medical Research Institute  NIH  1R01MH094469  1R01MH107649-01 Lundbeck Foundation  R102-A9118  R155-2014-1724 European Research Council  294838 European Community's Horizon 2020 Programme (H2020/2014-2020)  667302 Novo Nordisk Foundation  Aarhus university  Copenhagen university  Merz  Shire  Lundbeck  Rhodes  Arbor  KenPharm  Ironshore  Akili Interactive Labs  CogCubed  Alcobra  VAYA  Sunovion  Genomind  NeuroLifeSciences  Neurovance  Otsuka  McNeil  Janssen  Novartis  Pfizer  Eli Lilly 
  • BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) shows substantial heritability and is two to seven times more common in male individuals than in female individuals. We examined two putative genetic mechanisms underlying this sex bias: sex-specific heterogeneity and higher burden of risk in female cases.METHODS: We analyzed genome-wide autosomal common variants from the Psychiatric Genomics Consortium and iPSYCH Project (n = 20,183 cases, n = 35,191 controls) and Swedish population register data (n = 77,905 cases, n = 1,874,637 population controls).RESULTS: Genetic correlation analyses using two methods suggested near complete sharing of common variant effects across sexes, with r(g) estimates close to 1. Analyses of population data, however, indicated that female individuals with ADHD may be at especially high risk for certain comorbid developmental conditions (i.e., autism spectrum disorder and congenital malformations), potentially indicating some clinical and etiological heterogeneity. Polygenic risk score analysis did not support a higher burden of ADHD common risk variants in female cases (odds ratio [confidence interval] = 1.02 [0.98-1.06], p = .28). In contrast, epidemiological sibling analyses revealed that the siblings of female individuals with ADHD are at higher familial risk for ADHD than the siblings of affected male individuals (odds ratio [confidence interval] = 1.14 [1.11-1.18], p = 1.5E-15).CONCLUSIONS: Overall, this study supports a greater familial burden of risk in female individuals with ADHD and some clinical and etiological heterogeneity, based on epidemiological analyses. However, molecular genetic analyses suggest that autosomal common variants largely do not explain the sex bias in ADHD prevalence.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Walters, Raymond K.Stanley Center for Psychiatric Research, Broad Institute, Cambridge Massachusetts, United States; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston Massachusetts, United States (författare)
  • Demontis, DitteCentre for Integrative Sequencing [iSEQ], Aarhus University, Aarhus, Roskilde, Denmark; Department of Biomedicine–Human Genetics, Aarhus University, Aarhus, Roskilde, Denmark (författare)
  • Mattheisen, ManuelKarolinska Institutet (författare)
  • Lee, S. HongQueensland Brain Institute, University of Queensland, Brisbane Queensland, Australia; School of Environmental and Rural Science, University of New England, Armidale NSW, Australia; Centre for Population Health Research, School of Health Sciences and Sansom Institute of Health Research, University of South Australia, Adelaide, Australia (författare)
  • Robinson, EliseStanley Center for Psychiatric Research, Broad Institute, Cambridge Massachusetts, United States; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston Massachusetts, United States (författare)
  • Brikell, IsabellKarolinska Institutet (författare)
  • Ghirardi, LauraKarolinska Institutet (författare)
  • Larsson, Henrik,1975-Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology & Biostatistics, Karolinska Institutet, Stockholm, Sweden(Swepub:oru)hiln (författare)
  • Lichtenstein, PaulKarolinska Institutet (författare)
  • Eriksson, Nicholas23andMe Inc., Mountain View California, United States (författare)
  • Werge, ThomasLundbeck Foundation Initiative for Integrative Psychiatric Research [iPSYCH], Aarhus, Roskilde, Denmark; Institute of Biological Psychiatry, MHC Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark (författare)
  • Mortensen, Preben BoLundbeck Foundation Initiative for Integrative Psychiatric Research [iPSYCH], Aarhus, Roskilde, Denmark; Centre for Integrative Sequencing [iSEQ], Aarhus University, Aarhus, Roskilde, Denmark; National Centre for Register-Based Research, Aarhus University, Aarhus, Roskilde, Denmark; Centre for Integrated Register-Based Research, Aarhus University, Aarhus, Roskilde, Denmark (författare)
  • Pedersen, Marianne GiortzLundbeck Foundation Initiative for Integrative Psychiatric Research [iPSYCH], Aarhus, Roskilde, Denmark; National Centre for Register-Based Research, Aarhus University, Aarhus, Roskilde, Denmark; Centre for Integrated Register-Based Research, Aarhus University, Aarhus, Roskilde, Denmark (författare)
  • Mors, OleLundbeck Foundation Initiative for Integrative Psychiatric Research [iPSYCH], Aarhus, Roskilde, Denmark; Psychosis Research Unit, Aarhus University Hospital, Risskov, Denmark (författare)
  • Nordentoft, MereteLundbeck Foundation Initiative for Integrative Psychiatric Research [iPSYCH], Aarhus, Roskilde, Denmark; Mental Health Services in the Capital Region of Denmark, Mental Health Center Copenhagen, University of Copenhagen, Copenhagen, Denmark (författare)
  • Hougaard, David M.Lundbeck Foundation Initiative for Integrative Psychiatric Research [iPSYCH], Aarhus, Roskilde, Denmark; Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark (författare)
  • Bybjerg-Grauholm, JonasLundbeck Foundation Initiative for Integrative Psychiatric Research [iPSYCH], Aarhus, Roskilde, Denmark; Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark (författare)
  • Wray, Naomi R.Queensland Brain Institute, University of Queensland, Brisbane Queensland, Australia (författare)
  • Franke, BarbaraDepartments of Human Genetics and Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, Netherlands (författare)
  • Faraone, Stephen V.Departments of Psychiatry and of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse NY, United States; K.G. Jebsen Centre for Research on Neuropsychiatric Disorders, University of Bergen, Bergen, Norway (författare)
  • O'Donovan, Michael C.MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, United Kingdom (författare)
  • Thapar, AnitaMRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, United Kingdom (författare)
  • Børglum, Anders D.Lundbeck Foundation Initiative for Integrative Psychiatric Research [iPSYCH], Aarhus, Roskilde, Denmark; Centre for Integrative Sequencing [iSEQ], Aarhus University, Aarhus, Roskilde, Denmark; Department of Biomedicine–Human Genetics, Aarhus University, Aarhus, Roskilde, Denmark (författare)
  • Neale, Benjamin M.Stanley Center for Psychiatric Research, Broad Institute, Cambridge Massachusetts, United States; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston Massachusetts, United States (författare)
  • Karolinska InstitutetStanley Center for Psychiatric Research, Broad Institute, Cambridge Massachusetts, United States; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston Massachusetts, United States (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Biological Psychiatry: Elsevier83:12, s. 1044-10530006-32231873-2402

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