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- Evert, JasmineSchool of Medical Sciences, Örebro University, Örebro, Sweden (författare)
A Study on Effect of Oxaliplatin in MicroRNA Expression in Human Colon Cancer
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
- Sydney, Australia :Ivyspring International Publisher,2018
- printrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:oru-67344
- https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-67344URI
- https://doi.org/10.7150/jca.24474DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-149402URI
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- Språk:engelska
- Sammanfattning på:engelska
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- SwePubSwePub
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Anmärkningar
- Funding Agency:Health Research Council in the South-East of Sweden
- Funding Agencies|Swedish Cancer Foundation; Swedish Research Council; Health Research Council in the South-East of Sweden
- Colorectal cancer is a commonly diagnosed malignancy and also the major cause of death worldwide. Chemotherapy is the primary therapy for advanced colorectal cancer. Although oxaliplatin has potential effect in colorectal cancer therapy, the molecular mechanisms involved in its cytotoxic effects are not well elucidated. This study outlines the regulatory effects of oxaliplatin on miRNAs expression in colon cancer cells and correlates it with the changing microRNA expression with p53 and p73 expression status in cells. HCT116(p53+/+) and HCT116(p53-/-) cells were exposed to oxaliplatin, and the cellular viability was determined by XTT. p73 was knocked down using siRNA and the tumor cells were then treated with oxaliplatin. The expression profile of 384 miRNAs was determined by TaqMan (R) human miRNA array and calculated by the Delta Delta C-t method. Cellular viability was found to decrease after the treatment with oxaliplatin in a dose-dependent manner. The wild-type p53 cells were found to be more sensitive than the null-p53 derivatives. A selective set of miRNAs were either up-regulated or down-regulated in response to the oxaliplatin treatment with a presumable role of p53 and p73 proteins. The miRNAs expression is known to influence the pharmacodynamic mechanisms of oxaliplatin and these effects have been observed to be regulated by p53 and p73. Our results may therefore provide more evidence for identifying a suitable biomarker for the diagnosis of colon cancer.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
- Oxaliplatin
- miRNAs
- p53
- p73
- colon cancer cells
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Pathak, SurajitLinköpings universitet,Medicinska fakulteten,Avdelningen för kliniska vetenskaper,Region Östergötland, Onkologiska kliniken US,Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Kelambakkam, India(Swepub:liu)surpa77 (författare)
- Sun, Xiao-FengLinköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US(Swepub:liu)xiasu45 (författare)
- Zhang, Hong,1957-Örebro universitet,Institutionen för medicinska vetenskaper,School of Medical Sciences, Örebro University, Örebro, Sweden(Swepub:oru)hzg (författare)
- School of Medical Sciences, Örebro University, Örebro, SwedenMedicinska fakulteten (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Journal of CancerSydney, Australia : Ivyspring International Publisher9:11, s. 2046-20531837-9664
Internetlänk
- https://doi.org/10.7150/jca.24474Fulltext
- https://doi.org/10.7150/jca.24474
- https://liu.diva-portal.org/smash/get/diva2:1229254/FULLTEXT01.pdffulltext:print
- https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-67344
- https://doi.org/10.7150/jca.24474
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-149402
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