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  • Lamichhane, SantoshTurku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland (författare)

Dynamics of Plasma Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes - Type 1 Diabetes Prediction and Prevention Study (DIPP)

  • Artikel/kapitelEngelska2018

Förlag, utgivningsår, omfång ...

  • 2018-07-13
  • Nature Publishing Group,2018
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-68333
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-68333URI
  • https://doi.org/10.1038/s41598-018-28907-8DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:138808639URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies:JDRF  4-1998-274  4-1999-731 4-2001-435 Juvenile Diabetes Research Foundation  2-SRA-2014-159-Q-R Academy of Finland (Centre of Excellence in Molecular Systems Immunology and Physiology Research - SyMMyS)  250114 Turku University Hospitals in Finland  Special research funds for Oulu, Tampere 
  • Type 1 diabetes (T1D) is one of the most prevalent autoimmune diseases among children in Western countries. Earlier metabolomics studies suggest that T1D is preceded by dysregulation of lipid metabolism. Here we used a lipidomics approach to analyze molecular lipids in a prospective series of 428 plasma samples from 40 children who progressed to T1D (PT1D), 40 children who developed at least a single islet autoantibody but did not progress to T1D during the follow-up (P1Ab) and 40 matched controls (CTR). Sphingomyelins were found to be persistently downregulated in PT1D when compared to the P1Ab and CTR groups. Triacylglycerols and phosphatidylcholines were mainly downregulated in PT1D as compared to P1Ab at the age of 3 months. Our study suggests that distinct lipidomic signatures characterize children who progressed to islet autoimmunity or overt T1D, which may be helpful in the identification of at-risk children before the initiation of autoimmunity.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Ahonen, LindaSteno Diabetes Center Copenhagen, Gentofte, Denmark (författare)
  • Dyrlund, Thomas SparholtSteno Diabetes Center Copenhagen, Gentofte, Denmark (författare)
  • Kemppainen, EskoTurku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland (författare)
  • Siljander, HeliChildren's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Research Program Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland (författare)
  • Hyöty, HeikkiFaculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland; Fimlab Laboratories, Pirkanmaa Hospital District, Tampere, Finland (författare)
  • Ilonen, JormaImmunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland; Clinical Microbiology, Turku University Hospital, Turku, Finland (författare)
  • Toppari, JormaInstitute of Biomedicine, Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, Finland; Department of Pediatrics, Turku University Hospital, Turku, Finland (författare)
  • Veijola, RiittaDepartment of Paediatrics, PEDEGO Research Unit, University of Oulu Finland, Oulu, Finland; Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland; Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden (författare)
  • Hyötyläinen, Tuulia,1971-Örebro universitet,Institutionen för naturvetenskap och teknik,Department of Chemistry(Swepub:oru)tihn (författare)
  • Knip, MikaelChildren's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Research Program Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland; Tampere Center for Child Health Research, Tampere University Hospital, Tampere, Finland; Folkhälsan Research Center, Helsinki, Finland (författare)
  • Oresic, Matej,1967-Örebro universitet,Institutionen för medicinska vetenskaper,Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland(Swepub:oru)moc (författare)
  • Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, FinlandSteno Diabetes Center Copenhagen, Gentofte, Denmark (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Scientific Reports: Nature Publishing Group82045-2322

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