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Short Telomere Leng...
Short Telomere Length Is Related to Limitations in Physical Function in Elderly European Adults
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- Montiel Rojas, Diego, 1984- (författare)
- Örebro universitet,Institutionen för hälsovetenskaper
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- Nilsson, Andreas, 1973- (författare)
- Örebro universitet,Institutionen för hälsovetenskaper
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- Ponsot, Elodie, 1973- (författare)
- Örebro universitet,Institutionen för hälsovetenskaper
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- Brummer, Robert Jan, 1957- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper
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- Fairweather-Tait, Susan (författare)
- Norwich Medical School, University of East Anglia, Norwich, United Kingdom
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- Jennings, Amy (författare)
- Norwich Medical School, University of East Anglia, Norwich, United Kingdom
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- de Groot, Lisette C. P. G. M. (författare)
- Department of Human Nutrition, Wageningen University & Research, Wageningen, Netherlands
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- Berendsen, Agnes (författare)
- Department of Human Nutrition, Wageningen University & Research, Wageningen, Netherlands
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- Pietruszka, Barbara (författare)
- Department of Human Nutrition, Warsaw University of Life Sciences, Warsaw, Poland
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- Madej, Dawid (författare)
- Department of Human Nutrition, Warsaw University of Life Sciences, Warsaw, Poland
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- Caumon, Elodie (författare)
- Centre de Recherche en Nutrition Humaine d’Auvergne, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France
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- Meunier, Nathalie (författare)
- Centre de Recherche en Nutrition Humaine d’Auvergne, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France
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- Malpuech-Brugere, Corinne (författare)
- Unité de Nutrition Humaine, Institut National de la Recherche Agronomique, Centre de Recherche en Nutrition Humaine d’Auvergne, Université Clermont Auvergne, Clermont-Ferrand, France
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- Guidarelli, Giulia (författare)
- Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy
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- Santoro, Aurelia (författare)
- Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy; Interdepartmental Center “L. Galvani” (CIG), University of Bologna, Bologna, Italy
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- Franceschi, Claudio (författare)
- Bellaria Hospital, Institute of Neurological Sciences, University of Bologna, Bologna, Italy
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- Kadi, Fawzi, 1970- (författare)
- Örebro universitet,Institutionen för hälsovetenskaper
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(creator_code:org_t)
- 2018-08-10
- 2018
- Engelska.
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Ingår i: Frontiers in Physiology. - : Frontiers Media S.A.. - 1664-042X. ; 9
- Relaterad länk:
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https://doi.org/10.3...
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https://www.frontier...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- The present study aims to explore the potential influence of leucocyte telomere length (LTL) on both a single indicator and a composite construct of physical functioning in a large European population of elderly men and women across diverse geographical locations. A total of 1,221 adults (65-79 years) were recruited from five European countries within the framework of NU-AGE study. The physical functioning construct was based on the 36-item Short Form Health Survey. Handgrip strength was used as a single indicator of muscle function and LTL was assessed using quantitative real-time PCR. Women had significantly longer (p < 0.05) LTL than men. Participants in Poland had significantly shorter LTL than in the other study centers, whereas participants in the Netherlands had significantly longer LTL than most of the other centers (p < 0.01). An analysis of LTL as a continuous outcome against physical functioning by using linear models revealed inconsistent findings. In contrast, based on an analysis of contrasting telomere lengths (first vs. fifth quintile of LTL), a significant odds ratio (OR) of 1.7 (95% CI: 1.1 -2.6; p < 0.05) of having functional limitation was observed in those belonging to the first LTL quintile compared to the fifth. Interestingly, having the shortest LTL was still related to a higher likelihood of having physical limitation when compared to all remaining quintiles (OR: 1.5, 95% CI: 1.1 -2.1; p < 0.05), even after adjustment by study center, age, sex, and overweight status. Collectively, our findings suggest that short LTL is an independent risk factor that accounts for functional decline in elderly European populations. The influence of LTL on functional limitation seems driven by the detrimental effect of having short telomeres rather than reflecting a linear dose-response relationship.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Nyckelord
- aging
- ethnicity
- handgrip strength
- SF-36
- physical function
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Montiel Rojas, D ...
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Nilsson, Andreas ...
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Ponsot, Elodie, ...
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Brummer, Robert ...
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Fairweather-Tait ...
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Jennings, Amy
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de Groot, Lisett ...
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Berendsen, Agnes
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Pietruszka, Barb ...
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Madej, Dawid
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Caumon, Elodie
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Meunier, Nathali ...
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Malpuech-Brugere ...
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Guidarelli, Giul ...
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Santoro, Aurelia
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Franceschi, Clau ...
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Kadi, Fawzi, 197 ...
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