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Systematic review w...
Systematic review with meta-analysis : the prevalence of coeliac disease in patients with osteoporosis
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- Laszkowska, M. (författare)
- Department of Medicine, Celiac Disease Center, Columbia University College of Physicians and Surgeons, New York NY, USA,Columbia Univ Coll Phys & Surg, Dept Med, Celiac Dis Ctr, New York, NY USA
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- Mahadev, S. (författare)
- Department of Medicine, Celiac Disease Center, Columbia University College of Physicians and Surgeons, New York NY, USA,Columbia Univ Coll Phys & Surg, Dept Med, Celiac Dis Ctr, New York, NY USA
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- Sundström, Johan, Professor, 1971- (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Klinisk epidemiologi
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- Lebwohl, B. (författare)
- Department of Medicine, Celiac Disease Center, Columbia University College of Physicians and Surgeons, New York NY, USA,Columbia Univ Coll Phys & Surg, Dept Med, Celiac Dis Ctr, New York, NY USA
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- Green, P. H. R. (författare)
- Department of Medicine, Celiac Disease Center, Columbia University College of Physicians and Surgeons, New York NY, USA,Columbia Univ Coll Phys & Surg, Dept Med, Celiac Dis Ctr, New York, NY USA
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- Michaëlsson, Karl, 1959- (författare)
- Uppsala universitet,Ortopedi
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- Ludvigsson, Jonas F., 1969- (författare)
- Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Medicine, Celiac Disease Center, Columbia University College of Physicians and Surgeons, New York NY, USA; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Paediatrics, Örebro University Hospital, Örebro, Sweden; Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, Nottingham, UK,Columbia Univ Coll Phys & Surg, Dept Med, Celiac Dis Ctr, New York, NY USA;Karolinska Inst, Dept Med Epidemiol & Biostat, S-17177 Stockholm, Sweden;Orebro Univ Hosp, Dept Paediat, Orebro, Sweden;Univ Nottingham, Sch Med, Div Epidemiol & Publ Hlth, Nottingham, England
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(creator_code:org_t)
- 2018-07-08
- 2018
- Engelska.
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Ingår i: Alimentary Pharmacology and Therapeutics. - : Blackwell Publishing. - 0269-2813 .- 1365-2036. ; 48:6, s. 590-597
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
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- Background: Earlier studies have produced highly varying risk estimates for the prevalence of coeliac disease (CD) in osteoporosis.Aims: To investigate the prevalence of CD among individuals with osteoporosis.Methods: We conducted a systematic review of articles published in PubMed, Medline or EMBASE through May 2017 to identify studies looking at prevalence of CD in patients with osteoporosis. Search terms included "coeliac disease" combined with fractures, bone disease, bone density, densitometry, "osteoporos", "osteomal", "osteodys" or "dexa" or "dxa" or "skelet". Non-English papers with English-language abstracts were included. We used fixed-effects inverse variance-weighted models, and tested heterogeneity through subgroup analysis as well as through meta-regression.Results: We identified eight relevant studies, comprising data from 3188 individuals with osteoporosis. Of these, 59 individuals (1.9%) had CD. A weighted pooled analysis demonstrated biopsy-confirmed CD in 1.6% (95% CI=1.1%-2.0%) of individuals with osteoporosis. The heterogeneity was moderate (I-2=40.1%), and influenced by the underlying CD prevalence in the general population. After adding four studies (n=814) with CD defined as positive tissue transglutaminase or endomysial antibodies, the pooled prevalence was comparable (1.6%; 95% CI=1.2%-2.0%).Conclusions: About 1 in 62 individuals with osteoporosis, or 1.6%, have biopsy-verified CD. This prevalence is comparable to that in the general population. These findings argue against routinely screening patients with osteoporosis for CD, which is contrary to current guideline recommendations. Additional studies are needed to determine the true utility of such screening programs.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
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