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  • Ludvigsson, Jonas F.,1969-Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Medical epidemiology and Biostatistics, Karolinska institutet, Stockholm, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro, Sweden (författare)

Outcome measures in coeliac disease trials : the Tampere recommendations

  • Artikel/kapitelEngelska2018

Förlag, utgivningsår, omfång ...

  • 2018-02-13
  • BMJ Publishing Group Ltd,2018
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-68770
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-68770URI
  • https://doi.org/10.1136/gutjnl-2017-314853DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:139012109URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies:German Research Foundation (DFG)  Ministry of Research and Development (BMBF)  Leibniz Foundation  Biocard  Simtomax  Academy of Finland  Competitive Research Funding of the Tampere University Hospital  Sigrid Juselius Foundation   Hungarian Research Fund  NKFI 120392 Competitive State Research Financing of the Tampere University Hospital  9U038 
  • Objective: A gluten-free diet is the only treatment option of coeliac disease, but recently an increasing number of trials have begun to explore alternative treatment strategies. We aimed to review the literature on coeliac disease therapeutic trials and issue recommendations for outcome measures.Design: Based on a literature review of 10 062 references, we (17 researchers and 2 patient representatives from 10 countries) reviewed the use and suitability of both clinical and non-clinical outcome measures. We then made expert-based recommendations for use of these outcomes in coeliac disease trials and identified areas where research is needed. Results: We comment on the use of histology, serology, clinical outcome assessment (including patient-reported outcomes), quality of life and immunological tools including gluten immunogenic peptides for trials in coeliac disease.Conclusion: Careful evaluation and reporting of outcome measures will increase transparency and comparability of coeliac disease therapeutic trials, and will benefit patients, healthcare and the pharmaceutical industry.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Ciacci, CarolinaCoeliac Center at Department of Medicine and Surgery, Scuola Medica Salernitana, University of Salerno, Salerno, Italy (författare)
  • Green, Peter H. R.Celiac Disease Center at Columbia University, New York, USA (författare)
  • Kaukinen, KatriCeliac Disease Research Center, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland; Department of Internal Medicine, Tampere University Hospital, Tampere, Finland (författare)
  • Korponay-Szabo, Ilma R.Coeliac Disease Centre, Heim Pál Children’s Hospital, Budapest, Hungary; Department of Paediatrics, Faculty of Medicine, University of Debrecen, Debrecen, Hungary (författare)
  • Kurppa, KalleCeliac Disease Research Center, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland; Department of Paediatrics, Tampere University Hospital, Tampere, Finland (författare)
  • Murray, Joseph A.The Mayo Clinic, Rochester Minnesota, USA (författare)
  • Lundin, Knut Erik AslaksenInstitute of Clinical Medicine and K. G. Jebsen Coeliac Disease Research Centre, Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Gastroenterology, Oslo University Hospital, Oslo, Norway (författare)
  • Maki, Markku J.Science Center, Tampere University Hospital, Tampere, Finland; Tampere Centre for Child Health Research, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland (författare)
  • Popp, AlinaInstitute for Mother and Child Health Bucharest, University of Medicine and Pharmacy ’Carol Davila’, Bucharest, Romania; Tampere Centre for Child Health Research, University of Tampere, Tampere University Hospital, Tampere,Finland (författare)
  • Reilly, Norelle R.Division of Pediatric Gastroenterology, Columbia University Medical Center, New York, USA; Celiac Disease Center, Department of Medicine, Columbia University Medical Center, New York, USA (författare)
  • Rodriguez-Herrera, AlfonsoGupo IHP Pediatria, Sevilla, Spain (författare)
  • Sanders, David S.Academic Unit of Gastroenterology, Royal Hallamshire Hospital, University of Sheffield, Sheffield, UK (författare)
  • Schuppan, DetlefCeliac Center, University Medical Center, Johannes-Gutenberg University, Mainz, Germany; Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA (författare)
  • Sleet, SarahCoeliac UK, Buckinghamshire, UK (författare)
  • Taavela, JuhaTampere Centre for Child Health Research, University of Tampere, Tampere University Hospital, Tampere, Finland (författare)
  • Voorhees, KristinContinuum Clinical, Northbrook, Illinois, USA (författare)
  • Walker, Marjorie M.Faculty of Health and Medicine, School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia (författare)
  • Leffler, Daniel A.Celiac Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA (författare)
  • Örebro universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Gut: BMJ Publishing Group Ltd67:8, s. 1410-14240017-57491468-3288

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