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SERUM METABOLITES A...
SERUM METABOLITES ASSOCIATE WITH HEAD COMPUTED TOMOGRAPHY FINDINGS FOLLOWING TRAUMATIC BRAIN INJURY
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- Posti, Jussi P. (författare)
- Turku Brain Injury Centre, Turku University Hospital, Turku, Finland
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- Dickens, Alex (författare)
- Turku Centre For Biotechnology, University of Turku, Turku, Finland
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- Takala, Riikka S. (författare)
- Perioperative Services, Intensive Care Medicine and Pain, Turku University Hospital, Turku, Finland
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- Ala-Seppälä, Henna (författare)
- Department of Neurology, University of Turku, Turku, Finland
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- Mattila, Ismo (författare)
- Systems Medicine, Steno Diabetes Center Copenhagen, Gentofte, Denmark
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- Coles, Jonathan P. (författare)
- Division of Anaesthesia, University of Cambridge, Cambridge, England
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- Frantzén, Janek (författare)
- Division of Clinical Neurosciences, Department of Neurosurgery, Turku University Hospital, Turku, Finland
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- Hutchinson, Peter J. (författare)
- Division of Neurosurgery, University of Cambridge, Cambridge, England
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- Katila, Ari (författare)
- Perioperative Services, Intensive Care Medicine and Pain, Turku University Hospital, Turku, Finland
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- Kyllönen, Anna (författare)
- Department of Neurology, University of Turku, Turku, Finland
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- Maanpää, Henna-Riikka (författare)
- Division of Clinical Neurosciences, Department of Neurosurgery, Turku University Hospital, Turku, Finland
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- Newcombe, Virginia (författare)
- Division of Anaesthesia, University of Cambridge, Cambridge, England
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- Outtrim, Joanne (författare)
- Division of Anaesthesia, University of Cambridge, Cambridge, England
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- Tallus, Jussi (författare)
- Department of Neurology, University of Turku, Turku, Finland
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- Carpenter, Keri L. H. (författare)
- Division of Neurosurgery, University of Cambridge, Cambridge, England
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- Menon, David K. (författare)
- Division of Anaesthesia, University of Cambridge, Cambridge, England
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- Hyötyläinen, Tuulia, 1971- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,Department Of Chemistry
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- Tenovuo, Olli (författare)
- Turku Brain Injury Centre, Turku University Hospital, Turku, Finland
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- Oresic, Matej (författare)
- Turku Centre For Biotechnology, University of Turku, Turku, Finland
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(creator_code:org_t)
- Mary Ann Liebert, 2018
- 2018
- Engelska.
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Ingår i: Journal of Neurotrauma. - : Mary Ann Liebert. - 0897-7151 .- 1557-9042. ; 35:16, s. A67-A67
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- There is a need to rapidly detect patients with traumatic brain injury (TBI) who require head computed tomography (CT). Given the energy crisis in the brain following TBI, we hypothesized that serum metabolomics would be a useful tool for developing a set of bio-markers to determine the need for CT and to distinguish between different types of injuries observed. Logistic regression models using metabolite data from the discovery cohort (n=144, Turku, Finland) were used to distinguish between patients with traumatic intracranial findings and negative findings on head CT. The resultant models were then tested in the validation cohort (n=66, Cambridge, UK). The levels of glial fibrillary acidic protein and ubiquitin C-terminalhydrolase-L1 were also quantified in the serum from the same patients. Despite there being significant differences in the protein bio-markers in patients with TBI, the model that determined the need for a CT scan validated poorly (AUC=0.64: Cambridge patients). However, using a combination of six metabolites (two amino acids, thre esugar derivatives and one ketoacid) it was possible to discriminate patients with intracranial abnormalities on CT and patients with a normal CT (AUC=0.77 in Turku patients and AUC=0.73 in Cambridge patients). Furthermore, a combination of three metabolites could distinguish between diffuse brain injuries and mass lesions (AUC=0.87 in Turku patients and AUC=0.68 in Cambridge pa-tients). This study identifies a set of validated serum polar metabolites, which associate with the need for a CT scan. Additionally, serum metabolites can also predict the nature of the brain injury. These metabolite markers may prevent unnecessary CT scans, thus reducing the cost of diagnostics and radiation load.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Computational / Modeling
- Diagnostics
- Biomarker
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- Av författaren/redakt...
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Posti, Jussi P.
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Dickens, Alex
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Takala, Riikka S ...
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Ala-Seppälä, Hen ...
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Mattila, Ismo
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Coles, Jonathan ...
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visa fler...
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Frantzén, Janek
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Hutchinson, Pete ...
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Katila, Ari
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Kyllönen, Anna
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Maanpää, Henna-R ...
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Newcombe, Virgin ...
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Outtrim, Joanne
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Tallus, Jussi
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Carpenter, Keri ...
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Menon, David K.
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Hyötyläinen, Tuu ...
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Tenovuo, Olli
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Oresic, Matej
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Örebro universitet