Identification of metabolic profiles associated with human exposure to perfluoroalkyl substances

Salihovic, Samira,1985-Uppsala universitet,Örebro universitet,Institutionen för naturvetenskap och teknik,Department of Medical Sciences and Science for Life Laboratory, Molecular Epidemiology Unit, Uppsala University, Uppsala, Sweden,MTM Research Centre, School of Science and Technology, Örebro University,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab (författare)

Recent epidemiological studies suggest that human exposure to perfluoroalkyl substances (PFASs) may be associated with type 2 diabetes and other metabolic phenotypes. To gain further insights regarding PFASs exposure in humans, we here aimed to characterize the associations between different PFASs and the metabolome. In this cross-sectional study, we investigated 965 individuals from Sweden (all aged 70 years, 50% women) sampled in 2001-2004. PFASs were analyzed in plasma using isotope-dilution ultra-pressure liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS). Non-target metabolomics profiling was performed in plasma using UPLC coupled to time-of-flight mass spectrometry (UPLC-QTOFMS) operated in positive electrospray mode. Multivariate linear regression analysis was used to investigate associations between circulating levels of PFASs and metabolites. In total, 15 metabolites, predominantly from lipid pathways, were associated with levels of PFASs following adjustment for sex, smoking, exercise habits, education, energy, and alcohol intake, after correction for multiple testing. Perfluorononanoic acid (PFNA) and perfluoroundecanoic acid (PFUnDA) were strongly associated with multiple glycerophosphocholines and fatty acids including docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA). We also found that the different PFASs evaluated were associated with distinctive metabolic profiles, suggesting potentially different biochemical pathways in humans.

Fall, Tove,1979-Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi(Swepub:uu)tovfa878 (författare)
Ganna, AndreaMassachusetts General Hospital, Harvard Medical School and Broad Institute, Boston, MA, USA (författare)
Broeckling, Corey D.Proteomics and Metabolomics Facility, Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, USA (författare)
Prenni, Jessica E.Proteomics and Metabolomics Facility, Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, USA (författare)
Hyötyläinen, Tuulia,1971-Örebro universitet,Institutionen för naturvetenskap och teknik,MTM Research Centre(Swepub:oru)tihn (författare)
Kärrman, Anna,1975-Örebro universitet,Institutionen för naturvetenskap och teknik,MTM Research Centre(Swepub:oru)ankn (författare)
Lind, P. Monica,1957-Uppsala universitet,Arbets- och miljömedicin(Swepub:uu)monilind (författare)
Ingelsson, ErikDivision of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA (författare)
Lind, LarsUppsala universitet,Kardiovaskulär epidemiologi(Swepub:uu)larslind (författare)
Örebro universitetInstitutionen för naturvetenskap och teknik (creator_code:org_t)

Ingår i:Journal of Exposure Science and Environmental Epidemiology: Nature Publishing Group29:2, s. 196-2051559-06311559-064X

Av författaren/redakt...: Salihovic, Samir ...; Fall, Tove, 1979 ...; Ganna, Andrea; Broeckling, Core ...; Prenni, Jessica ...; Hyötyläinen, Tuu ...; visa fler...; Kärrman, Anna, 1 ...; Lind, P. Monica, ...; Ingelsson, Erik; Lind, Lars; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Hälsovetenskap; och Arbetsmedicin oc ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Hälsovetenskap; och Folkhälsovetensk ...

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.