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  • Burisch, JohanDepartment of Gastroenterology, Nordsjællands Hospital, University of Copenhagen, Frederikssund, Denmark (författare)

Natural Disease Course of Ulcerative Colitis During the First Five Years of Follow-up in a European Population-based Inception Cohort-An Epi-IBD Study

  • Artikel/kapitelEngelska2019

Förlag, utgivningsår, omfång ...

  • 2018-10-05
  • Oxford University Press,2019
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-69337
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-69337URI
  • https://doi.org/10.1093/ecco-jcc/jjy154DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies:Kirsten og Freddy Johansens Fond  Nordsjaellands Hospital Forskningsrad 
  • Background and Aims: Few population-based cohort studies have assessed the disease course of ulcerative colitis [UC] in the era of biological therapy and widespread use of immunomodulators. The aim of this study was to assess the 5-year outcome and disease course of patients with UC in the Epi-IBD cohort.Methods: In a prospective, population-based inception cohort of unselected patients with UC, patients were followed up from the time of their diagnosis, which included the collection of their clinical data, demographics, disease activity, medical therapy, and rates of surgery, cancers, and deaths. Associations between outcomes and multiple covariates were analysed by Cox regression analysis.Results: A total of 717 patients were included in the study. During follow-up, 43 [6%] patients underwent a colectomy and 163 [23%] patients were hospitalised. Of patients with limited colitis [distal to the left flexure], 90 [21%] progressed to extensive colitis. In addition, 92 [27%] patients with extensive colitis experienced a regression in disease extent, which was associated with a reduced risk of hospitalisation (hazard ratio [HR]: 0.5 95% CI: 0.3-0.8]. Overall, patients were treated similarly in both geographical regions; 80 [11%] patients needed biological therapy and 210 [29%] patients received immunomodulators. Treatment with immunomodulators was found to reduce the risk of hospitalisation [HR: 0.5 95% CI: 0.3-0.8].Conclusions: Although patients in this population-based cohort were treated more aggressively with immunomodulators and biological therapy than in cohorts from the previous two decades, their disease outcomes, including colectomy rates, were no different. However, treatment with immunomodulators was found to reduce the risk of hospitalisation.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Katsanos, Konstantinos H.Department of Gastroenterology, University Hospital of Ioannina, Ioannina, Greece (författare)
  • Christodoulou, Dimitrios K.Department of Gastroenterology, University Hospital of Ioannina, Ioannina, Greece (författare)
  • Barros, LuisaDepartment of Gastroenterology, Centro Hospitalar de São João EPE, Porto, Portugal (författare)
  • Magro, FernandoDepartment of Gastroenterology, Centro Hospitalar de São João EPE, Porto, Portugal; Department of Biomedicine, Institute of Pharmacology, Faculty of Medicine of Porto University, Porto, Portugal (författare)
  • Pedersen, NataliaGastroenterology Department, Slagelse Hospital, Slagelse, Denmark (författare)
  • Kjeldsen, JensGastroenterology Department, Odense University Hospital, Odense, Denmark (författare)
  • Vegh, ZsuzsannaFirst Department of Medicine, Semmelweis University, Budapest, Hungary (författare)
  • Lakatos, Peter L.First Department of Medicine, Semmelweis University, Budapest, Hungary; Division of Gastroenterology, McGill University Health Center, Montreal, QC, Canada (författare)
  • Eriksson, Carl,1981-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Gastroenterology(Swepub:oru)clen (författare)
  • Halfvarson, Jonas,1970-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology(Swepub:oru)jshn (författare)
  • Fumery, MathurinGastroenterology Unit, Epimad Registry, CHU Amiens Sud, Amiens University Hospital, Amiens, France (författare)
  • Gower-Rousseau, CorinnePublic Health, Epidemiology and Economic Health, Registre Epimad, Lille University and Hospital, Lille, France; Lille Inflammation Research International Center LIRIC, Lille University, Lille, France (författare)
  • Brinar, MarkoDivision of Gastroenterology and Hepatology, University Hospital Center Zagreb, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia (författare)
  • Čuković-Čavka, SilvijaDivision of Gastroenterology and Hepatology, University Hospital Center Zagreb, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia (författare)
  • Nikulina, InnaDepartment of Gastroenterology, Moscow Regional Research Clinical Institute, Moscow, Russian Federation (författare)
  • Belousova, ElenaDepartment of Gastroenterology, Moscow Regional Research Clinical Institute, Moscow, Russian Federation (författare)
  • Myers, SallyIBD Unit, Hull and East Yorkshire NHS Trust, Hull, UK (författare)
  • Sebastian, ShajiIBD Unit, Hull and East Yorkshire NHS Trust, Hull, UK (författare)
  • Kiudelis, GediminasInstitute for Digestive Research, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania (författare)
  • Kupcinskas, LimasInstitute for Digestive Research, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania; Department of Gastroenterology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania (författare)
  • Schwartz, DoronDepartment of Gastroenterology and Hepatology, Soroka Medical Center, Beer Sheva, Israel; Ben Gurion University of the Negev; Beer Sheva, Israel (författare)
  • Odes, SelwynDepartment of Gastroenterology and Hepatology, Soroka Medical Center, Beer Sheva, Israel; Ben Gurion University of the Negev; Beer Sheva, Israel (författare)
  • Kaimakliotis, Ioannis P.Nicosia Private Practice, Nicosia, Cyprus (författare)
  • Valpiani, DanielaU.O. Gastroenterologia ed Endoscopia digestiva, Hospital Morgagni Pierantoni, Forlì, Italy (författare)
  • D'Incà, RenataDepartment of Surgical, Oncological and Gastroenterological Sciences, Azienda, University of Padua, Padova, Italy (författare)
  • Salupere, RiinaDivision of Gastroenterology, Tartu University Hospital, University of Tartu, Tartu, Estonia (författare)
  • Zammit, Stefania ChetcutiDivision of Gastroenterology, Mater Dei Hospital, Msida, Malta (författare)
  • Ellul, PierreDivision of Gastroenterology, Mater Dei Hospital, Msida, Malta (författare)
  • Duricova, DanaIBD Clinical and Research Centre, ISCARE, Prague, Czech Republic (författare)
  • Bortlik, MartinIBD Clinical and Research Centre, ISCARE, Prague, Czech Republic; Institute of Pharmacology, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic (författare)
  • Goldis, AdrianClinic of Gastroenterology, University of Medicine ‘Victor Babes’, Timisoara, Romania (författare)
  • Kievit, Hendrika Adriana LindaDepartment of Medicine, Herning Central Hospital, Herning, Denmark (författare)
  • Toca, AlinaDepartment of Gastroenterology, State University of Medicine and Pharmacy of the Republic of Moldova, Chisinau, Republic of Moldova (författare)
  • Turcan, SvetlanaDepartment of Gastroenterology, State University of Medicine and Pharmacy of the Republic of Moldova, Chisinau, Republic of Moldova (författare)
  • Midjord, JóngerðMedical Department, National Hospital of the Faroe Islands, Torshavn, Faroe Islands (författare)
  • Nielsen, Kári RubekMedical Department, National Hospital of the Faroe Islands, Torshavn, Faroe Islands (författare)
  • Andersen, Karina WintherMedical Department, Regional Hospital of Viborg, Viborg, Denmark (författare)
  • Andersen, VibekeMedical Department, Regional Hospital of Viborg, Viborg, Denmark; Focused Research Unit for Molecular Diagnostic and Clinical Research [MOK], IRS-Center Sonderjylland, Hospital of Southern Jutland, Aabenraa, Denmark; Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark (författare)
  • Misra, RaviIBD Department, St Mark’s Hospital, London, UK (författare)
  • Arebi, NailaIBD Department, St Mark’s Hospital, London, UK (författare)
  • Oksanen, PiaDepartment of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland; University of Tampere, Tampere, Finland (författare)
  • Collin, PekkaDepartment of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland; University of Tampere, Tampere, Finland (författare)
  • de Castro, LuisaDepartment of Gastroenterology, Hospital Alvaro Cunqueiro, Instituto Investigación Sanitaria Galicia Sur, EOXI de Vigo, Vigo, Spain (författare)
  • Hernandez, VicentDepartment of Gastroenterology, Hospital Alvaro Cunqueiro, Instituto Investigación Sanitaria Galicia Sur, EOXI de Vigo, Vigo, Spain (författare)
  • Langholz, EbbeDepartment of Gastroenterology, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark (författare)
  • Munkholm, PiaDepartment of Gastroenterology, Nordsjællands Hospital, University of Copenhagen, Frederikssund, Denmark (författare)
  • Epi-IBD, Group (bidragsgivare)
  • Department of Gastroenterology, Nordsjællands Hospital, University of Copenhagen, Frederikssund, DenmarkDepartment of Gastroenterology, University Hospital of Ioannina, Ioannina, Greece (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Crohn's & Colitis: Oxford University Press13:2, s. 198-2081873-99461876-4479

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