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  • Lamichhane, SantoshTurku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland (author)

A longitudinal plasma lipidomics dataset from children who developed islet autoimmunity and type 1 diabetes

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2018-11-13
  • Springer Nature,2018
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-70175
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-70175URI
  • https://doi.org/10.1038/sdata.2018.250DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:139545565URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding agencies:JDRF (grants 4-1998-274, 4-1999-731 4-2001-435)Oulu, Tampere and Turku University HospitalsJuvenile Diabetes Research Foundation (2-SRA-2014-159-Q-R)Academy of Finland (Centre of Excellence in Molecular Systems Immunology and Physiology Research – SyMMyS, Decision No. 250114)
  • Early prediction and prevention of type 1 diabetes (T1D) are currently unmet medical needs. Previous metabolomics studies suggest that children who develop T1D are characterised by a distinct metabolic profile already detectable during infancy, prior to the onset of islet autoimmunity. However, the specificity of persistent metabolic disturbances in relation T1D development has not yet been established. Here, we report a longitudinal plasma lipidomics dataset from (1) 40 children who progressed to T1D during follow-up, (2) 40 children who developed single islet autoantibody but did not develop T1D and (3) 40 matched controls (6 time points: 3, 6, 12, 18, 24 and 36 months of age). This dataset may help other researchers in studying age-dependent progression of islet autoimmunity and T1D as well as of the age-dependence of lipidomic profiles in general. Alternatively, this dataset could more broadly used for the development of methods for the analysis of longitudinal multivariate data.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Ahonen, LindaSteno Diabetes Center Copenhagen, Gentofte, Denmark (author)
  • Dyrlund, Thomas SparholtSteno Diabetes Center Copenhagen, Gentofte, Denmark (author)
  • Siljander, HeliChildren’s Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Research Program Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland (author)
  • Hyöty, HeikkiFaculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland; Fimlab Laboratories, Pirkanmaa Hospital District, Tampere, Finland (author)
  • Ilonen, JormaImmunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland; Clinical Microbiology, Turku University Hospital, Turku, Finland (author)
  • Toppari, JormaInstitute of Biomedicine, Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, Finland; Department of Pediatrics, Turku University Hospital, Turku, Finland (author)
  • Veijola, RiittaDepartment of Paediatrics, PEDEGO Research Unit, Medical Research Centre, University of Oulu, Oulu, Finland; Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland; Department of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden (author)
  • Hyötyläinen, Tuulia,1971-Örebro universitet,Institutionen för naturvetenskap och teknik,Department of Chemistry(Swepub:oru)tihn (author)
  • Knip, MikaelChildren’s Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Research Program Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland; Tampere Center for Child Health Research, Tampere University Hospital, Tampere, Finland; Folkhälsan Research Center, Helsinki, Finland (author)
  • Oresic, Matej,1967-Örebro universitet,Institutionen för medicinska vetenskaper,Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland(Swepub:oru)moc (author)
  • Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, FinlandSteno Diabetes Center Copenhagen, Gentofte, Denmark (creator_code:org_t)

Related titles

  • In:Scientific Data: Springer Nature52052-4463

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