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Current EU research activities on combined exposure to multiple chemicals

Bopp, Stephanie K. (author)
European Commission, Directorate General Joint Research Centre, Directorate F – Health, Consumers and Reference Materials, Ispra, Italy
Barouki, Robert (author)
INSERM UMR-S 1124, Université Paris Descartes, Paris, France
Brack, Werner (author)
Helmholtz Centre for Environmental Research – UFZ, Leipzig, Germany
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Dalla Costa, Silvia (author)
European Commission, Directorate General Joint Research Centre, Directorate B – Growth and Innovation, Ispra, Italy
Dorne, Jean-Lou C. M. (author)
Scientific Committee and Emerging Risks Unit, European Food Safety Authority (EFSA), Parma, Italy
Drakvik, Paula E. (author)
Swetox, Karolinska Institutet, Unit of Toxicology Sciences, Södertälje, Sweden
Faust, Michael (author)
Faust & Backhaus Environmental Consulting, Bremen, Germany
Karjalainen, Tuomo K. (author)
European Commission, Directorate General Research and Innovation, Directorate E – Health, Brussels, Belgium
Kephalopoulos, Stylianos (author)
European Commission, Directorate General Joint Research Centre, Directorate F – Health, Consumers and Reference Materials, Ispra, Italy
van Klaveren, Jacob (author)
National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherland
Kolossa-Gehring, Marike (author)
German Environment Agency, UBA, Berlin, Germany
Kortenkamp, Andreas (author)
Institute for Environment, Health and Societies, Brunel University, Uxbridge, United Kingdom
Lebret, Erik (author)
National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands; Institute of Risk Assessment Sciences – IRAS, Utrecht University, Utrecht, the Netherlands
Lettieri, Teresa (author)
European Commission, Directorate General Joint Research Centre, Directorate D – Sustainable Resources, Ispra, Italy
Nørager, Sofie (author)
European Commission, Directorate General Research and Innovation, Directorate E – Health, Brussels, Belgium
Rüegg, Joelle (author)
Karolinska Institutet
Tarazona, Jose V. (author)
Pesticides Unit, European Food Safety Authority (EFSA), Parma, Italy
Trier, Xenia (author)
European Environment Agency, Copenhagen, Denmark
van de Water, Bob (author)
Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands
van Gils, Jos (author)
Deltares, Delft, the Netherlands
Bergman, Åke, 1950- (author)
Örebro universitet,Institutionen för naturvetenskap och teknik,Swetox, Karolinska Institutet, Unit of Toxicology Sciences, Södertälje, Sweden
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 (creator_code:org_t)
Elsevier, 2018
2018
English.
In: Environment International. - : Elsevier. - 0160-4120 .- 1873-6750. ; 120, s. 544-562
Related links:
https://doi.org/10.1...
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https://doi.org/10.1...
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Research review (peer-reviewed)
Abstract Subject headings
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  • Humans and wildlife are exposed to an intractably large number of different combinations of chemicals via food, water, air, consumer products, and other media and sources. This raises concerns about their impact on public and environmental health. The risk assessment of chemicals for regulatory purposes mainly relies on the assessment of individual chemicals. If exposure to multiple chemicals is considered in a legislative framework, it is usually limited to chemicals falling within this framework and co-exposure to chemicals that are covered by a different regulatory framework is often neglected. Methodologies and guidance for assessing risks from combined exposure to multiple chemicals have been developed for different regulatory sectors, however, a harmonised, consistent approach for performing mixture risk assessments and management across different regulatory sectors is lacking. At the time of this publication, several EU research projects are running, funded by the current European Research and Innovation Programme Horizon 2020 or the Seventh Framework Programme. They aim at addressing knowledge gaps and developing methodologies to better assess chemical mixtures, by generating and making available internal and external exposure data, developing models for exposure assessment, developing tools for in silico and in vitro effect assessment to be applied in a tiered framework and for grouping of chemicals, as well as developing joint epidemiological-toxicological approaches for mixture risk assessment and for prioritising mixtures of concern. The projects EDC-MixRisk, EuroMix, EUToxRisk, HBM4EU and SOLUTIONS have started an exchange between the consortia, European Commission Services and EU Agencies, in order to identify where new methodologies have become available and where remaining gaps need to be further addressed. This paper maps how the different projects contribute to the data needs and assessment methodologies and identifies remaining challenges to be further addressed for the assessment of chemical mixtures.

Subject headings

NATURVETENSKAP  -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
NATURAL SCIENCES  -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)

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