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Methods for the dif...
Methods for the differential integrative omic analysis of plasma from a transgenic disease animal model
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- Davidov, Eugene (author)
- 1Beyond Genomics, Inc., Waltham, Massachusetts, USA
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- Clish, Clary B. (author)
- 1Beyond Genomics, Inc., Waltham, Massachusetts, USA
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- Oresic, Matej, 1967- (author)
- 1Beyond Genomics, Inc., Waltham, Massachusetts, USA
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- Meys, Michael (author)
- 1Beyond Genomics, Inc., Waltham, Massachusetts, USA
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- Stochaj, Wayne (author)
- 1Beyond Genomics, Inc., Waltham, Massachusetts, USA
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- Snell, Philip (author)
- 1Beyond Genomics, Inc., Waltham, Massachusetts, USA
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- Lavine, Gary (author)
- 1Beyond Genomics, Inc., Waltham, Massachusetts, USA
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- Londo, Thomas R. (author)
- 1Beyond Genomics, Inc., Waltham, Massachusetts, USA
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- Adourian, Aram (author)
- 1Beyond Genomics, Inc., Waltham, Massachusetts, USA
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- Zhang, Xiang (author)
- 1Beyond Genomics, Inc., Waltham, Massachusetts, USA
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- Johnston, Mark (author)
- 1Beyond Genomics, Inc., Waltham, Massachusetts, USA
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- Morel, Nicole (author)
- 1Beyond Genomics, Inc., Waltham, Massachusetts, USA
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- Marple, Edward W. (author)
- 1Beyond Genomics, Inc., Waltham, Massachusetts, USA
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- Plasterer, Thomas N. (author)
- 1Beyond Genomics, Inc., Waltham, Massachusetts, USA
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- Neumann, Eric (author)
- 1Beyond Genomics, Inc., Waltham, Massachusetts, USA
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- Verheij, Elwin (author)
- TNO Pharma, Zeist, The Netherlands
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- Vogels, Jack T. W. E. (author)
- TNO Pharma, Zeist, The Netherlands
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- Havekes, Louis M. (author)
- TNO Prevention and Health, Gaubius Laboratorium, Leiden, The Netherlands; Departments of Cardiology and Internal Medicine and Leiden/Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden University, Leiden, The Netherlands
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- van der Greef, Jan (author)
- 1Beyond Genomics, Inc., Waltham, Massachusetts, USA; TNO Pharma, Zeist, The Netherlands; Departments of Cardiology and Internal Medicine and Leiden/Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden University, Leiden, The Netherlands
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- Naylor, Stephen (author)
- 1Beyond Genomics, Inc., Waltham, Massachusetts, USA
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1Beyond Genomics, Inc, Waltham, Massachusetts, USA TNO Pharma, Zeist, The Netherlands (creator_code:org_t)
- Mary Ann Liebert, 2004
- 2004
- English.
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In: Omics. - : Mary Ann Liebert. - 1536-2310 .- 1557-8100. ; 8:4, s. 267-288
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Multitiered quantitative analysis of biological systems is rapidly becoming the desired approach to study hierarchical functional interactions between proteins and metabolites. We describe here a novel systematic approach to analyze organisms with complex metabolic regulatory networks. By using precise analytical methods to measure biochemical constituents and their relative abundance in whole plasma of transgenic ApoE*3-Leiden mice and an isogenic wild-type control group, simultaneous snapshots of metabolic and protein states were obtained. Novel data processing and multivariate analysis tools such as Impurity Resolution Software (IMPRESS) and Windows-based linear fit program (WINLIN) were used to compare protein and metabolic profiles in parallel. Canonical correlations of the resulting data show quantitative relationships between heterogeneous components in the TG animals. These results, obtained solely from whole plasma analysis allowed us, in a rapid manner, to corroborate previous findings as well as find new events pertaining to dominant and peripheral events in lipoprotein metabolism of a genetically modified mammalian organism in relation to ApoE3, a key mediator of lipoprotein metabolism.
Subject headings
- NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Davidov, Eugene
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Clish, Clary B.
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Oresic, Matej, 1 ...
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Meys, Michael
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Stochaj, Wayne
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Snell, Philip
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Lavine, Gary
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Londo, Thomas R.
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Adourian, Aram
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Zhang, Xiang
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Johnston, Mark
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Morel, Nicole
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Marple, Edward W ...
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Plasterer, Thoma ...
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Neumann, Eric
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Verheij, Elwin
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Vogels, Jack T. ...
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Havekes, Louis M ...
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van der Greef, J ...
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Naylor, Stephen
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- NATURAL SCIENCES
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NATURAL SCIENCES
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Omics
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Örebro University