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The link between nu...
The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-gamma2 isoform
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- Medina-Gomez, Gema (author)
- Department of Clinical Biochemistry, Histopathology, Physiology and Oncology, University of Cambridge/Addenbrooke’s Hospital, Cambridge, U.K
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- Virtue, Sam (author)
- Department of Clinical Biochemistry, Histopathology, Physiology and Oncology, University of Cambridge/Addenbrooke’s Hospital, Cambridge, U.K
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- Lelliott, Christopher (author)
- Department of Clinical Biochemistry, Histopathology, Physiology and Oncology, University of Cambridge/Addenbrooke’s Hospital, Cambridge, U.K
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- Boiani, Romina (author)
- Institute of Normal Human Morphology, Faculty of Medicine, Ancona University, Ancona, Italy
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- Campbell, Mark (author)
- Department of Clinical Biochemistry, Histopathology, Physiology and Oncology, University of Cambridge/Addenbrooke’s Hospital, Cambridge, U.K
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- Christodoulides, Constantinos (author)
- Department of Clinical Biochemistry, Histopathology, Physiology and Oncology, University of Cambridge/Addenbrooke’s Hospital, Cambridge, U.K
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- Perrin, Christophe (author)
- Centre National de la Recherche Scientifique, Paul Sabatier University, Toulouse, France
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- Jimenez-Linan, Mercedes (author)
- Department of Clinical Biochemistry, Histopathology, Physiology and Oncology, University of Cambridge/Addenbrooke’s Hospital, Cambridge, U.K
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- Blount, Margaret (author)
- Department of Clinical Biochemistry, Histopathology, Physiology and Oncology, University of Cambridge/Addenbrooke’s Hospital, Cambridge, U.K
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- Dixon, John (author)
- Paradigm Therapeutics, Cambridge, U.K
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- Zahn, Dirk (author)
- Paradigm Therapeutics, Cambridge, U.K
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- Thresher, Rosemary R. (author)
- Paradigm Therapeutics, Cambridge, U.K
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- Aparicio, Sam (author)
- Paradigm Therapeutics, Cambridge, U.K
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- Carlton, Mark (author)
- Paradigm Therapeutics, Cambridge, U.K
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- Colledge, William H. (author)
- Department of Clinical Biochemistry, Histopathology, Physiology and Oncology, University of Cambridge/Addenbrooke’s Hospital, Cambridge, U.K
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- Kettunen, Mikko I. (author)
- Department of Biochemistry, University of Cambridge, Cambridge, U.K.
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- Seppänen-Laakso, Tuulikki (author)
- VTT: Technical Research Centre of Finland, VTT Biotechnology, Espoo, Finland
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- Sethi, Jaswinder K. (author)
- Department of Clinical Biochemistry, Histopathology, Physiology and Oncology, University of Cambridge/Addenbrooke’s Hospital, Cambridge, U.K
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- O'Rahilly, Stephen (author)
- Department of Clinical Biochemistry, Histopathology, Physiology and Oncology, University of Cambridge/Addenbrooke’s Hospital, Cambridge, U.K
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- Brindle, Kevin (author)
- Department of Biochemistry, University of Cambridge, Cambridge, U.K.
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- Cinti, Saverio (author)
- Institute of Normal Human Morphology, Faculty of Medicine, Ancona University, Ancona, Italy
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- Oresic, Matej, 1967- (author)
- VTT: Technical Research Centre of Finland, VTT Biotechnology, Espoo, Finland
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- Burcelin, Remy (author)
- Centre National de la Recherche Scientifique, Paul Sabatier University, Toulouse, France
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- Vidal-Puig, Antonio (author)
- Department of Clinical Biochemistry, Histopathology, Physiology and Oncology, University of Cambridge/Addenbrooke’s Hospital, Cambridge, U.K
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Department of Clinical Biochemistry, Histopathology, Physiology and Oncology, University of Cambridge/Addenbrooke’s Hospital, Cambridge, UK Institute of Normal Human Morphology, Faculty of Medicine, Ancona University, Ancona, Italy (creator_code:org_t)
- American Diabetes Association, 2005
- 2005
- English.
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In: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 54:6, s. 1706-1716
- Related links:
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https://doi.org/10.2...
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http://diabetes.diab...
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Abstract
Subject headings
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- The nuclear receptor peroxisome proliferator-activated receptor-gamma (PPARgamma) is critically required for adipogenesis. PPARgamma exists as two isoforms, gamma1 and gamma2. PPARgamma2 is the more potent adipogenic isoform in vitro and is normally restricted to adipose tissues, where it is regulated more by nutritional state than PPARgamma1. To elucidate the relevance of the PPARgamma2 in vivo, we generated a mouse model in which the PPARgamma2 isoform was specifically disrupted. Despite similar weight, body composition, food intake, energy expenditure, and adipose tissue morphology, male mice lacking the gamma2 isoform were more insulin resistant than wild-type animals when fed a regular diet. These results indicate that insulin resistance associated with ablation of PPARgamma2 is not the result of lipodystrophy and suggests a specific role for PPARgamma2 in maintaining insulin sensitivity independently of its effects on adipogenesis. Furthermore, PPARgamma2 knockout mice fed a high-fat diet did not become more insulin resistant than those on a normal diet, despite a marked increase in their mean adipocyte cell size. These findings suggest that PPARgamma2 is required for the maintenance of normal insulin sensitivity in mice but also raises the intriguing notion that PPARgamma2 may be necessary for the adverse effects of a high-fat diet on carbohydrate metabolism.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Andra medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Other Basic Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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Diabetes
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Medina-Gomez, Ge ...
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Virtue, Sam
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Lelliott, Christ ...
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Boiani, Romina
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Campbell, Mark
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Christodoulides, ...
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show more...
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Perrin, Christop ...
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Jimenez-Linan, M ...
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Blount, Margaret
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Dixon, John
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Zahn, Dirk
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Thresher, Rosema ...
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Aparicio, Sam
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Carlton, Mark
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Colledge, Willia ...
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Kettunen, Mikko ...
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Seppänen-Laakso, ...
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Sethi, Jaswinder ...
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O'Rahilly, Steph ...
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Brindle, Kevin
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Cinti, Saverio
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Oresic, Matej, 1 ...
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Burcelin, Remy
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Vidal-Puig, Anto ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Other Basic Medi ...
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MEDICAL AND HEAL ...
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and Endocrinology an ...
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Diabetes
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Örebro University