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  • Medina-Gomez, GemaDepartment of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom (author)

PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism

  • Article/chapterEnglish2007

Publisher, publication year, extent ...

  • 2007-04-27
  • Public Library of Science (PLoS),2007
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-70906
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-70906URI
  • https://doi.org/10.1371/journal.pgen.0030064DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Peroxisome proliferator activated receptor gamma 2 (PPARg2) is the nutritionally regulated isoform of PPARg. Ablation of PPARg2 in the ob/ob background, PPARg2(-/-) Lep(ob)/Lep(ob) (POKO mouse), resulted in decreased fat mass, severe insulin resistance, beta-cell failure, and dyslipidaemia. Our results indicate that the PPARg2 isoform plays an important role, mediating adipose tissue expansion in response to positive energy balance. Lipidomic analyses suggest that PPARg2 plays an important antilipotoxic role when induced ectopically in liver and muscle by facilitating deposition of fat as relatively harmless triacylglycerol species and thus preventing accumulation of reactive lipid species. Our data also indicate that PPARg2 may be required for the beta-cell hypertrophic adaptive response to insulin resistance. In summary, the PPARg2 isoform prevents lipotoxicity by (a) promoting adipose tissue expansion, (b) increasing the lipid-buffering capacity of peripheral organs, and (c) facilitating the adaptive proliferative response of beta-cells to insulin resistance.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Gray, Sarah L.Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom (author)
  • Yetukuri, LaxmanTechnical Research Centre of Finland (VTT), Espoo, Finland (author)
  • Shimomura, KenjuUniversity Laboratory of Physiology, University of Oxford, Oxford, United Kingdom (author)
  • Virtue, SamDepartment of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom (author)
  • Campbell, MarkDepartment of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom (author)
  • Curtis, R. KeiraDepartment of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom (author)
  • Jimenez-Linan, MercedesDepartment of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom (author)
  • Blount, MargaretDepartment of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom (author)
  • Yeo, Giles S. H.Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom (author)
  • Lopez, MiguelDepartment of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom (author)
  • Seppänen-Laakso, TuulikkiTechnical Research Centre of Finland (VTT), Espoo, Finland (author)
  • Ashcroft, Frances M.University Laboratory of Physiology, University of Oxford, Oxford, United Kingdom (author)
  • Oresic, Matej,1967-Technical Research Centre of Finland (VTT), Espoo, Finland(Swepub:oru)moc (author)
  • Vidal-Puig, AntonioDepartment of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom (author)
  • Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United KingdomTechnical Research Centre of Finland (VTT), Espoo, Finland (creator_code:org_t)

Related titles

  • In:PLOS Genetics: Public Library of Science (PLoS)3:41553-73901553-7404

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