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Metabolomic changes...
Metabolomic changes in fatty liver can be modified by dietary protein and calcium during energy restriction
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- Pilvi, Taru-K. (author)
- Institute of Biomedicine, Pharmacology, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland; Foundation for Nutrition Research, Helsinki, Finland; Valio Ltd, Research Center, Valio, Helsinki, Finland
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- Seppanen-Laakso, Tuulikki (author)
- VTT Technical Research Centre of Finland, Finland
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- Simolin, Helena (author)
- VTT Technical Research Centre of Finland, Finland
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- Finckenberg, Piet (author)
- Institute of Biomedicine, Pharmacology, Biomedicum Helsink, University of Helsinki, Helsinki, Finland
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- Huotari, Anne (author)
- Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland
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- Herzig, Karl-Heinz (author)
- Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland; Department of Internal Medicine, Kuopio University Hospital, Kuopio, Finland; Institute of Biomedicine, Department of Physiology, and Biocenter of Oulu, University of Oulu, Oulu, Finland
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- Korpela, Riitta (author)
- Institute of Biomedicine, Pharmacology, Biomedicum Helsink, University of Helsinki, Helsinki, Finland; Foundation for Nutrition Research, Helsinki, Finland; Valio Ltd, Research Center, Valio, Helsinki, Finland
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- Oresic, Matej, 1967- (author)
- VTT Technical Research Centre of Finland, Finland
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- Mervaala, Eero-M. (author)
- Institute of Biomedicine, Pharmacology, Biomedicum Helsink, University of Helsinki, Helsinki, Finland
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(creator_code:org_t)
- Baishideng Publishing Group Co., Limited, 2008
- 2008
- English.
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In: World Journal of Gastroenterology. - : Baishideng Publishing Group Co., Limited. - 1007-9327 .- 2219-2840. ; 14:28, s. 4462-4472
- Related links:
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https://doi.org/10.3...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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Abstract
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- AIM: To characterise the effect of energy restriction (ER) on liver lipid and primary metabolite profile by using metabolomic approach. We also investigated whether the effect of energy restriction can be further enhanced by modification of dietary protein source and calcium.METHODS: Liver metabolomic profile of lean and obese C57Bl/6J mice (n = 10/group) were compared with two groups of weight-reduced mice. ER was performed on control diet and whey protein-based high-calcium diet (whey + Ca). The metabolomic analyses were performed using the UPLC/MS based lipidomic platform and the HPLC/MS/MS based primary metabolite platform.RESULTS: ER on both diets significantly reduced hepatic lipid accumulation and lipid droplet size, while only whey + Ca diet significantly decreased blood glucose (P < 0.001) and serum insulin (P < 0.01). In hepatic lipid species the biggest reduction was in the level of triacylglycerols and ceramides while the level of cholesterol esters was significantly increased during ER. Interestingly, diacylglycerol to phospholipid ratio, an indicator of relative amount of diabetogenic diglyceride species, was increased in the control ER group, but decreased in the whey + Ca ER group (P < 0.001, vs obese). ER on whey + Ca diet also totally reversed the obesity induced increase in the relative level of lipotoxic ceramides (P < 0.001, vs obese; P > 0.05, vs lean). These changes were accompanied with up-regulated TCA cycle and pentose phosphate pathway metabolites.CONCLUSION: ER-induced changes on hepatic metabolomic profile can be significantly affected by dietary protein source. The therapeutic potential of whey protein and calcium should be further studied.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- Fatty liver
- metabolomics
- energy restriction
- whey protein
- dietary calcium
Publication and Content Type
- ref (subject category)
- art (subject category)
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Pilvi, Taru-K.
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Seppanen-Laakso, ...
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Simolin, Helena
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Finckenberg, Pie ...
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Huotari, Anne
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Herzig, Karl-Hei ...
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Korpela, Riitta
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Oresic, Matej, 1 ...
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Mervaala, Eero-M ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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Örebro University