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Sökning: id:"swepub:oai:DiVA.org:oru-70944" > The effect of fatty...

  • de Mello, Vanessa D. F.Department of Clinical Nutrition/Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland (författare)

The effect of fatty or lean fish intake on inflammatory gene expression in peripheral blood mononuclear cells of patients with coronary heart disease

  • Artikel/kapitelEngelska2009

Förlag, utgivningsår, omfång ...

  • 2009-06-09
  • Steinkopff-Verlag,2009
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-70944
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-70944URI
  • https://doi.org/10.1007/s00394-009-0033-yDOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • BACKGROUND: Little is known about the effect of fish consumption on gene expression of inflammation-related genes in immune cells in coronary heart disease (CHD).AIM OF THE STUDY: We sought to evaluate the effect of a fatty fish (FF) or a lean fish (LF) diet on the modulation of inflammatory and endothelial function-related genes in peripheral blood mononuclear cells (PBMCs) of subjects with CHD, and its association with serum fatty acid (FA) profile and lipid metabolic compounds.METHODS: Data from 27 patients randomized into an 8-week FF (n = 10; mean +/- SD: 4.3 +/- 0.4 portions of fish per week), LF (n = 11; 4.7 +/- 1.1 portions of fish per week), or control diet (n = 6; 0.6 +/- 0.4 portions of fish per week) were analyzed. The mRNA expression was measured using real-time PCR.RESULTS: The effect of the intervention on the mRNA expression of the genes studied did not differ among groups. In the FF group, however, the decrease in arachidonic acid to eicosapentaenoic acid (AA:EPA) ratio in cholesterol ester and phospholipid fractions strongly correlated with the change in IL1B mRNA levels (r (s) = 0.60, P = 0.06 and r (s) = 0.86, P = 0.002, respectively). In the LF group, the decrease in palmitic acid and total saturated FAs in cholesterol esters correlated with the change in intercellular cell adhesion molecule-1 (ICAM1) expression (r (s) = 0.64, P = 0.04 for both). Circulating levels of soluble ICAM-1 decreased only in the LF group (P < 0.05).CONCLUSIONS: The intake of FF or LF diet did not alter the expression of inflammatory and endothelial function-related genes in PBMCs of patients with CHD. However, the decrease in AA:EPA ratio in serum lipids in the FF group may induce an anti-inflammatory response at mRNA levels in PBMCs. A LF diet might benefit endothelial function, possibly mediated by the changes in serum FA composition.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Erkkilä, Arja T.Department of Public Health, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland (författare)
  • Schwab, Ursula S.Department of Clinical Nutrition/Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland; Department of Internal Medicine, Kuopio University Hospital, Kuopio, Finland (författare)
  • Pulkkinen, LeenaDepartment of Clinical Nutrition/Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland (författare)
  • Kolehmainen, MarjukkaDepartment of Clinical Nutrition/Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland (författare)
  • Atalay, MustafaDepartment of Physiology, Institute of Biomedicine, University of Kuopio, Kuopio, Finland (författare)
  • Mussalo, HannaDepartment of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland (författare)
  • Lankinen, MariaDepartment of Clinical Nutrition/Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland; VTT Technical Research Centre of Finland, Espoo, Finland (författare)
  • Oresic, Matej,1967-VTT Technical Research Centre of Finland, Espoo, Finland(Swepub:oru)moc (författare)
  • Lehto, SeppoDepartment of Internal Medicine, Kuopio University Hospital, Kuopio, Finland (författare)
  • Uusitupa, MattiDepartment of Clinical Nutrition/Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland (författare)
  • Department of Clinical Nutrition/Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, FinlandDepartment of Public Health, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:European Journal of Nutrition: Steinkopff-Verlag48:8, s. 447-4551436-62071436-6215

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