An ecotoxicological view on neurotoxicity assessment

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An ecotoxicological view on neurotoxicity assessment

Legradi, J. B. (författare): Institute for Environmental Research, Department of Ecosystem Analysis, ABBt–Aachen Biology and Biotechnology, RWTH Aachen University, Aachen, Germany; Environment and Health, VU University, Amsterdam, Netherlands

Di Paolo, C. (författare): Institute for Environmental Research, Department of Ecosystem Analysis, ABBt–Aachen Biology and Biotechnology, RWTH Aachen University, Aachen, Germany

Kraak, M. H. S. (författare): FAME-Freshwater and Marine Ecology, Institute for Biodiversity and Ecosystem Dynamics, University of Amsterdam, Amsterdam, Netherlands

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van der Geest, H. G. (författare): FAME-Freshwater and Marine Ecology, Institute for Biodiversity and Ecosystem Dynamics, University of Amsterdam, Amsterdam, Netherlands

Schymanski, E. L. (författare): Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Belvaux, Luxembourg

Williams, A. J. (författare): National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park NC, United States

Dingemans, M. M. L. (författare): KWR Watercycle Research Institute, Nieuwegein, Netherlands

Massei, R. (författare): Department Effect-Directed Analysis, Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany

Brack, W. (författare): Department Effect-Directed Analysis, Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany

Cousin, X. (författare): Ifremer, UMR MARBEC, Laboratoire Adaptation et Adaptabilités des Animaux et des Systèmes, Palavas-les-Flots, France; INRA, UMR GABI, INRA, AgroParisTech, Domaine de Vilvert, Jouy-en-Josas, France

Begout, M. -L (författare): Ifremer, Laboratoire Ressources Halieutiques, L’Houmeau, France

van der Oost, R. (författare): Department of Technology, Research and Engineering, Waternet Institute for the Urban Water Cycle, Amsterdam, Netherlands

Carion, A. (författare): Laboratory of Evolutionary and Adaptive Physiology, Institute of Life, Earth and Environment, University of Namur, Namur, Belgium

Suarez-Ulloa, V. (författare): Laboratory of Evolutionary and Adaptive Physiology, Institute of Life, Earth and Environment, University of Namur, Namur, Belgium

Silvestre, F. (författare): Laboratory of Evolutionary and Adaptive Physiology, Institute of Life, Earth and Environment, University of Namur, Namur, Belgium

Escher, B. I. (författare): Department of Cell Toxicology, Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany; Eberhard Karls University Tübingen, Environmental Toxicology, Center for Applied Geosciences, Tübingen, Germany

Engwall, Magnus, 1965- (författare): Örebro universitet,Institutionen för naturvetenskap och teknik,MTM Research Centre

Nilén, Greta, 1989- (författare): Örebro universitet,Institutionen för naturvetenskap och teknik,MTM Research Centre

Keiter, Steffen, 1971- (författare): Örebro universitet,Institutionen för naturvetenskap och teknik,MTM Research Centre

Pollet, D. (författare): Faculty of Chemical Engineering and Biotechnology, University of Applied Sciences Darmstadt, Darmstadt, Germany

Waldmann, P. (författare): Faculty of Chemical Engineering and Biotechnology, University of Applied Sciences Darmstadt, Darmstadt, Germany

Kienle, C. (författare): Swiss Centre for Applied Ecotoxicology Eawag-EPFL, Dübendorf, Switzerland

Werner, I. (författare): Swiss Centre for Applied Ecotoxicology Eawag-EPFL, Dübendorf, Switzerland

Haigis, A. -C (författare): Institute for Environmental Research, Department of Ecosystem Analysis, ABBt–Aachen Biology and Biotechnology, RWTH Aachen University, Aachen, Germany

Knapen, D. (författare): Zebrafishlab, Veterinary Physiology and Biochemistry, University of Antwerp, Wilrijk, Belgium

Vergauwen, L. (författare): Zebrafishlab, Veterinary Physiology and Biochemistry, University of Antwerp, Wilrijk, Belgium

Spehr, M. (författare): Institute for Biology II, Department of Chemosensation, RWTH Aachen University, Aachen, Germany

Schulz, W. (författare): Zweckverband Landeswasserversorgung, Langenau, Germany

Busch, W. (författare): Department of Bioanalytical Ecotoxicology, UFZ–Helmholtz Centre for Environmental Research, Leipzig, Germany

Leuthold, D. (författare): Department of Bioanalytical Ecotoxicology, UFZ–Helmholtz Centre for Environmental Research, Leipzig, Germany

Scholz, S. (författare): Department of Bioanalytical Ecotoxicology, UFZ–Helmholtz Centre for Environmental Research, Leipzig, Germany

vom Berg, C. M. (författare): Department of Environmental Toxicology, Swiss Federal Institute of Aquatic Science and Technology, Eawag, Dübendorf, Switzerland

Basu, N. (författare): Faculty of Agricultural and Environmental Sciences, McGill University, Montreal, Canada

Murphy, C. A. (författare): Department of Fisheries and Wildlife, Michigan State University, East Lansing, United States

Lampert, A. (författare): Institute of Physiology (Neurophysiology), Aachen, Germany

Kuckelkorn, J. (författare): Section Toxicology of Drinking Water and Swimming Pool Water, Federal Environment Agency (UBA), Bad Elster, Germany

Grummt, T. (författare): Section Toxicology of Drinking Water and Swimming Pool Water, Federal Environment Agency (UBA), Bad Elster, Germany

Hollert, H. (författare): Institute for Environmental Research, Department of Ecosystem Analysis, ABBt–Aachen Biology and Biotechnology, RWTH Aachen University, Aachen, Germany

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2018-12-14
2018
Engelska.
Ingår i: Environmental Sciences Europe. - : Springer. - 2190-4707 .- 2190-4715. ; 30

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://enveurope.sp...; https://urn.kb.se/re...; https://doi.org/10.1...; visa färre...

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The numbers of potential neurotoxicants in the environment are raising and pose a great risk for humans and the environment. Currently neurotoxicity assessment is mostly performed to predict and prevent harm to human populations. Despite all the efforts invested in the last years in developing novel in vitro or in silico test systems, in vivo tests with rodents are still the only accepted test for neurotoxicity risk assessment in Europe. Despite an increasing number of reports of species showing altered behaviour, neurotoxicity assessment for species in the environment is not required and therefore mostly not performed. Considering the increasing numbers of environmental contaminants with potential neurotoxic potential, eco-neurotoxicity should be also considered in risk assessment. In order to do so novel test systems are needed that can cope with species differences within ecosystems. In the field, online-biomonitoring systems using behavioural information could be used to detect neurotoxic effects and effect-directed analyses could be applied to identify the neurotoxicants causing the effect. Additionally, toxic pressure calculations in combination with mixture modelling could use environmental chemical monitoring data to predict adverse effects and prioritize pollutants for laboratory testing. Cheminformatics based on computational toxicological data from in vitro and in vivo studies could help to identify potential neurotoxicants. An array of in vitro assays covering different modes of action could be applied to screen compounds for neurotoxicity. The selection of in vitro assays could be guided by AOPs relevant for eco-neurotoxicity. In order to be able to perform risk assessment for eco-neurotoxicity, methods need to focus on the most sensitive species in an ecosystem. A test battery using species from different trophic levels might be the best approach. To implement eco-neurotoxicity assessment into European risk assessment, cheminformatics and in vitro screening tests could be used as first approach to identify eco-neurotoxic pollutants. In a second step, a small species test battery could be applied to assess the risks of ecosystems.

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An ecotoxicological view on neurotoxicity assessment

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