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Tick-borne encephal...
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Hansson, KarinCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden; Department of Infectious diseases, Södersjukhuset, Stockholm, Sweden
(author)
Tick-borne encephalitis (TBE) vaccine failures : A ten-year retrospective study supporting the rationale for adding an extra priming dose in individuals from the age of 50 years
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Publisher, publication year, extent ...
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2019-03-07
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Oxford University Press,2020
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Numbers
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LIBRIS-ID:oai:DiVA.org:oru-73197
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-73197URI
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https://doi.org/10.1093/cid/ciz176DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:142749537URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies:Research Committee of Orebro lan OLL-768871Hennes Kungliga Höghet Kronprinsessan Lovisas förening for barnasjukvård/Stiftelsen Axel Tielmans Minnesfond
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BACKGROUND: Southern Sweden is endemic for tick borne encephalitis (TBE), with Stockholm County as one of the high-risk areas. The aim of this study was to describe cases of vaccine failures, and to optimize future vaccination recommendations.METHODS: Patients with TBE were identified in the notification database at the Department of Communicable Disease Control and Prevention in the county of Stockholm during 2006-2015. Vaccine failure was defined as TBE despite adherence to the recommended vaccination schedule with at least two doses. Clinical data were extracted from medical records.RESULTS: A total of 1004 TBE cases were identified, 53 (5%) were defined as vaccine failures. In this latter group the median age was 62 years (6-83). Forty-three (81%) patients were over 50 years of age and two were children. Approximately half of the patients had comorbidities with diseases affecting the immune system accounting for 26% of all cases.Vaccine failures following the third or fourth vaccine dose accounted for 36 (68%) of the patients. Severe and moderate TBE disease affected 81% of the cases.CONCLUSION: To our knowledge, this is the largest documented cohort of TBE-vaccine failures. Vaccine failure after five TBE-vaccine doses is rare. Our data provides rationale for adding an extra priming dose to the age group 50 years and older.
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Rosdahl, Anja,1972-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Infectious Diseases, Örebro University Hospital, Örebro, Sweden(Swepub:oru)aarl
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Insulander, MonaDepartment of Communicable Disease Control and Prevention, Stockholm County, Stockholm, Sweden
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Vene, SirkkaPublic Health Agency of Sweden, Solna, Sweden
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Lindquist, LarsDepartment of Medicine, Karolinska Institutet, Stockholm, Huddinge, Sweden; Department of Infectious diseases, Karolinska University Hospital, Stockholm, Sweden
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Gredmark-Russ, SaraKarolinska Institutet
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Askling, Helena H.Karolinska Institutet
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Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden; Department of Infectious diseases, Södersjukhuset, Stockholm, SwedenInstitutionen för medicinska vetenskaper
(creator_code:org_t)
Related titles
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In:Clinical Infectious Diseases: Oxford University Press70:2, s. 245-2511058-48381537-6591
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