The Association Between Beta-Blockade and Clinical Outcomes in the Context of Surgical and Traumatic Stress

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: WFRF:(Mohseni Shahin docent 1978 ) > (2019) > The Association Bet...

1 of 1
Previous record
Next record
To hitlist

Details
MARC

Ahl, Rebecka,1987-Örebro universitet,Institutionen för medicinska vetenskaper (author)

The Association Between Beta-Blockade and Clinical Outcomes in the Context of Surgical and Traumatic Stress

BookEnglish2019

Publisher, publication year, extent ...

Örebro :Örebro University,2019
96 s.
printrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:oru-73256
ISBN:9789175292779
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-73256URI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:vet swepub-contenttype
Subject category:dok swepub-publicationtype

Series

Örebro Studies in Medicine,1652-4063 ;194

Notes

Traumatic injury and major abdominal surgery are areas in general surgery associated with high rates of morbidity and mortality. The overall colorectal cancer surgery mortality rate is around 4%, with that for emergency surgery more than twice as high as for planned. Surgical morbidity varies between 25% and 45%. Around half of trauma patients develop low mood. In one quarter of patients this becomes permanent. Depression is known to impede physical rehabilitation and recovery. The onset of physiological stress, driven by adrenergic hyperactivity following traumatic and surgical injury is hypothesized to contribute to these adverse outcomes. Interest has therefore been sparked into blocking adrenergic receptor activation.Papers I and II investigated the role of beta-blocker therapy in preventing post-traumatic depression following severe traumatic brain injury (Paper I) and severe extracranial injury (Paper II). The Karolinska University Hospital Trauma Registry was used to identify patients admitted between 2007 and 2011. In Paper I (n = 545), patients on pre-injury beta-blocker therapy were matched to beta-blocker naïve patients with equivalent injury burden. Results revealed that beta-blocked patients exhibited a 60% reduced risk of needing antidepressant therapy within one year of trauma. In Paper II (n = 596), the lack of beta-blocker use before extracranial trauma was linked to a three-fold increase in the risk of antidepressant initiation.Papers III-V explored the role of pre-operative beta-blocker therapy in patients undergoing surgery for colorectal cancer between 2007 and 2016, identified using the nationwide Swedish Colorectal Cancer Registry. Paper III (n = 3,187) identified a 69% reduction in the risk of 30-day mortality in beta-blocked patients. Paper IV (n = 22,337) outlined long-term survival benefits for patients on beta-blocker therapy prior to undergoing elective surgery for colon cancer. Beta-blocked patients showed a risk reduction of 42% for 1-year all-cause mortality and 18% for 5-year cancerspecific mortality. Similarly, patients on beta-blocker therapy who underwent surgery for rectal cancer demonstrated improved survival up to one year after surgery with a risk reduction of 57% and a reduction in anastomotic failure and infectious complications in Paper V (n = 11,966).

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kirurgi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Surgery hsv//eng
Beta-blocker therapy
adrenergic hyperactivity
physiological stress
trauma
depression
colorectal cancer
complications
mortality

Added entries (persons, corporate bodies, meetings, titles ...)

Mohseni, Shahin,docent,1978-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län(Swepub:oru)snmi (thesis advisor)
Riddez, Louis,docentKarolinska Institutet, Stockholm; Karolinska Sjukhuset, Solna (thesis advisor)
Wallin, Göran,adjungerad professor,1952-Örebro universitet,Institutionen för medicinska vetenskaper(Swepub:oru)gwn (thesis advisor)
Ljungqvist, Olle,professor,1954-Örebro universitet,Institutionen för medicinska vetenskaper(Swepub:oru)olt (thesis advisor)
Tilsed, Jonathan,professorHull & East Yorkshire Hospitals NHS (opponent)
Örebro universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

Internet link

Find in a library

The Association Between Beta-Blockade and Clinical Outcomes in the Context of Su... (Search the publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Ahl, Rebecka, 19 ...; Mohseni, Shahin, ...; Riddez, Louis, d ...; Wallin, Göran, a ...; Ljungqvist, Olle ...; Tilsed, Jonathan ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Surgery

Parts in the series: Örebro Studies i ...

By the university: Örebro University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se