Sökning: L773:0300 5577 OR L773:1619 3997 >
Expression of genes...
Expression of genes involved in inflammation and growth : does sampling site in human full-term placenta matter?
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- Allbrand, Marianne, 1958- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Obstetrics and Gynecology
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- Åman, Jan (författare)
- Department of Pediatrics, School of Medical Sciences, Örebro University, Örebro, Sweden
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- Nilsson, Kerstin, 1953- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Obstetrics and Gynecology
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- Cao, Yang, Associate Professor, 1972- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Unit of Biostatistics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden,Clinical Epidemiology and Biostatistics
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- Lodefalk, Maria, 1968- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Pediatrics, School of Medical Sciences, Örebro University, Örebro, Sweden; University Health Care Research Center, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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(creator_code:org_t)
- 2019-03-28
- 2019
- Engelska.
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Ingår i: Journal of Perinatal Medicine. - : Walter de Gruyter. - 0300-5577 .- 1619-3997. ; 47:5, s. 539-546
- Relaterad länk:
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https://doi.org/10.1...
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https://www.degruyte...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Objective: To investigate the placental gene expression of substances in the inflammatory cascade and growth factors at nine different well-defined sampling sites in full-term placentas from 12 normal weight healthy non-smoking women with an uncomplicated singleton pregnancy.Methods: All placentas (six girls and six boys) were delivered vaginally. Quantitative real-time polymerase chain reaction was used to analyze toll receptor-2 and -4, interleukin-6 and -8, tumor necrosis factor-α, leptin, ghrelin, insulin-like growth factor-1 and -2, hepatocyte growth factor, hepatocyte growth factor receptor and insulin receptor (IR).Results: The leptin gene and the IR gene showed higher expression in lateral regions near the chorionic plate compared to central regions near the basal plate (P = 0.028 and P = 0.041, respectively).Conclusion: Our results suggest that the sampling site may influence the gene expression for leptin and IR in placental tissue obtained from full-term normal pregnancies. We speculate that this may be due to differences in placental structure and perfusion and may be important when future studies are designed.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Nyckelord
- Cytokines
- gene expression
- growth factors
- placenta
- sampling
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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