Search: (L773:0724 4983 OR L773:1433 8726) srt2:(2020-2023) >
No increased risk o...
No increased risk of short-term complications after radical cystectomy for muscle-invasive bladder cancer among patients treated with preoperative chemotherapy : a nation-wide register-based study
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- Jerlström, Tomas, 1969- (author)
- Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Urology,Orebro Univ, Sweden
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- Ruoqing, Chen, 1985- (author)
- Örebro University,Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden,Clinical Epidemiology and Biostatistics,Orebro Univ, Sweden; Karolinska Inst, Sweden
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- Liedberg, Fredrik (author)
- Lund University,Lunds universitet,Urologi - blåscancer, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Urology - urothelial cancer, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital,Skane Univ Hosp, Sweden; Lund Univ, Sweden
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- Andrén, Ove, 1963- (author)
- Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Urology,Orebro Univ, Sweden
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- Ströck, Viveka (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska University Hospital,Sahlgrens Univ Hosp, Sweden; Sahlgrens Acad, Sweden,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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- Sherif, Amir (author)
- Umeå University,Linköping University,Umeå universitet,Urologi och andrologi,Umea Univ, Sweden
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- Hosseini, Abolfazl (author)
- Karolinska Institutet,Karolinska Inst, Sweden
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- Sherif, Amir (author)
- Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden
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- Malmström, Per-Uno (author)
- Uppsala University,Uppsala universitet,Urologkirurgi,Inst Surg Sci, Sweden
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- Ullén, Anders (author)
- Karolinska Institutet,Karolinska University Hospital,Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden
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- Gårdmark, Truls (author)
- Karolinska Institutet,Danderyd Hospital,Danderyd Hosp, Sweden
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- Fall, Katja, 1971- (author)
- Örebro University,Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Urology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden,Orebro Univ, Sweden; Karolinska Inst, Sweden
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- Abdul-Sattar Aljabery, Firas (author)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Urologiska kliniken i Östergötland
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(creator_code:org_t)
- 2019-04-24
- 2020
- English.
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In: World journal of urology. - : Springer. - 0724-4983 .- 1433-8726. ; 38:2, s. 381-388
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Abstract
Subject headings
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- PURPOSE: Preoperative chemotherapy is underused in conjunction with radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC) due to concerns for complications and delay of surgery. Prospective data on short-term complications from population-based settings with frequent use of preoperative chemotherapy and standardised reporting of complications is lacking.METHODS: We identified 1,340 patients who underwent RC between 2011 and 2015 in Sweden due to MIBC according to the Swedish Cystectomy Register. These individuals were followed through linkages to several national registers. Propensity score adjusted logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for complications and death within 90 days of surgery, comparing patients receiving preoperative chemotherapy or not.RESULTS: Minimum two cycles of preoperative chemotherapy were given to 519 (39%) of the patients, who on average tended to be younger, have higher education, better physical status, and more advanced bladder cancer than patients not receiving chemotherapy. After adjusting for these and other parameters, there was no association between treatment with preoperative chemotherapy and short-term complications (OR 1.06 95% CI 0.82-1.39) or mortality (OR 0.75 95% CI 0.36-1.55). We observed a risk reduction for gastrointestinal complications among patients who received preoperative chemotherapy compared with those who did not (OR 0.49 95% CI 0.30-0.81).CONCLUSION: This nation-wide population-based observational study does not suggest that preoperative chemotherapy, in a setting with high utilisation of such treatment, is associated with an increased risk of short-term complications in MIBC patients treated with radical cystectomy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- Bladder cancer
- Induction chemotherapy
- Neoadjuvant chemotherapy
- Postoperative complications
- Radical cystectomy
- Bladder cancer
- Induction chemotherapy
- Neoadjuvant chemotherapy
- Postoperative complications
- Radical cystectomy
Publication and Content Type
- ref (subject category)
- art (subject category)
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Jerlström, Tomas ...
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Ruoqing, Chen, 1 ...
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Liedberg, Fredri ...
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Andrén, Ove, 196 ...
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Ströck, Viveka
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Sherif, Amir
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Hosseini, Abolfa ...
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Malmström, Per-U ...
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Ullén, Anders
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Gårdmark, Truls
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Fall, Katja, 197 ...
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Abdul-Sattar Alj ...
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Örebro University
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Umeå University
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Uppsala University
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Lund University
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Linköping University
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Karolinska Institutet
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University of Gothenburg
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