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The acute transcriptional response to resistance exercise : impact of age and contraction mode

Deane, Colleen S. (författare)
Department of Sport and Health Sciences, College of Life and Environmental Sciences, University of Exeter, UK
Ames, Ryan M. (författare)
Living Systems Institute, University of Exeter, Exeter, UK
Phillips, Bethan E. (författare)
MRC ‐ ARUK Centre of Research Excellence and National Institute of Health Research, Biomedical Research Centre, Postgraduate Entry Medical School, Royal Derby Hospital Centre, School of Medicine, University of Nottingham, Derby, UK
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Weedon, Michael N. (författare)
Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK
Willis, Craig R. G. (författare)
Department of Sport and Health Sciences, College of Life and Environmental Sciences, University of Exeter, UK
Boereboom, Catherine (författare)
MRC ‐ ARUK Centre of Research Excellence and National Institute of Health Research, Biomedical Research Centre, Postgraduate Entry Medical School, Royal Derby Hospital Centre, School of Medicine, University of Nottingham, Derby, UK
Abdulla, Haitham (författare)
MRC ‐ ARUK Centre of Research Excellence and National Institute of Health Research, Biomedical Research Centre, Postgraduate Entry Medical School, Royal Derby Hospital Centre, School of Medicine, University of Nottingham, Derby, UK
Bukhari, Syed S. I. (författare)
MRC ‐ ARUK Centre of Research Excellence and National Institute of Health Research, Biomedical Research Centre, Postgraduate Entry Medical School, Royal Derby Hospital Centre, School of Medicine, University of Nottingham, Derby, UK
Lund, Jonathan N. (författare)
Department of Surgery, Postgraduate Entry Medical School, Royal Derby Hospital Centre, School of Medicine, University of Nottingham, Derby, UK
Williams, John P. (författare)
MRC ‐ ARUK Centre of Research Excellence and National Institute of Health Research, Biomedical Research Centre, Postgraduate Entry Medical School, Royal Derby Hospital Centre, School of Medicine, University of Nottingham, Derby, UK
Wilkinson, Daniel J. (författare)
MRC ‐ ARUK Centre of Research Excellence and National Institute of Health Research, Biomedical Research Centre, Postgraduate Entry Medical School, Royal Derby Hospital Centre, School of Medicine, University of Nottingham, Derby, UK
Smith, Kenneth (författare)
MRC ‐ ARUK Centre of Research Excellence and National Institute of Health Research, Biomedical Research Centre, Postgraduate Entry Medical School, Royal Derby Hospital Centre, School of Medicine, University of Nottingham, Derby, UK
Gallagher, Iain J. (författare)
Faculty of Health Sciences and Sport, University of Stirling, Stirling, UK
Kadi, Fawzi, 1970- (författare)
Örebro universitet,Institutionen för hälsovetenskaper
Szewczyk, Nathaniel J. (författare)
MRC ‐ ARUK Centre of Research Excellence and National Institute of Health Research, Biomedical Research Centre, Postgraduate Entry Medical School, Royal Derby Hospital Centre, School of Medicine, University of Nottingham, Derby, UK
Atherton, Philip J. (författare)
MRC ‐ ARUK Centre of Research Excellence and National Institute of Health Research, Biomedical Research Centre, Postgraduate Entry Medical School, Royal Derby Hospital Centre, School of Medicine, University of Nottingham, Derby, UK
Etheridge, Timothy (författare)
Department of Sport and Health Sciences, College of Life and Environmental Sciences, University of Exeter, UK
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 (creator_code:org_t)
2019-04-15
2019
Engelska.
Ingår i: Aging. - : Impact Journals LLC. - 1945-4589 .- 1945-4589. ; 11:7, s. 2111-2126
Relaterad länk:
https://doi.org/10.1...
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https://doi.org/10.1...
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Optimization of resistance exercise (RE) remains a hotbed of research for muscle building and maintenance. However, the interactions between the contractile components of RE (i.e. concentric (CON) and eccentric (ECC)) and age, are poorly defined. We used transcriptomics to compare age-related molecular responses to acute CON and ECC exercise. Eight young (21 +/- 1 y) and eight older (70 +/- 1 y) exercise-naive male volunteers had vastus lateralis biopsies collected at baseline and 5 h post unilateral CON and contralateral ECC exercise. RNA was subjected to next-generation sequencing and differentially expressed (DE) genes tested for pathway enrichment using Gene Ontology (GO). The young transcriptional response to CON and ECC was highly similar and older adults displayed moderate contraction-specific profiles, with no GO enrichment. Age-specific responses to ECC revealed 104 DE genes unique to young, and 170 DE genes in older muscle, with no GO enrichment. Following CON, 15 DE genes were young muscle-specific, whereas older muscle uniquely expressed 147 up-regulated genes enriched for cell adhesion and blood vessel development, and 28 down-regulated genes involved in mitochondria! respiration, amino acid and lipid metabolism. Thus, older age is associated with contraction-specific regulation often without clear functional relevance, perhaps reflecting a degree of stochastic age-related dysregulation.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Geriatrik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Geriatrics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

Nyckelord

concentric
eccentric
sarcopenia
transcriptome

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

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  • Aging (Sök värdpublikationen i LIBRIS)

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