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Search: (WFRF:(Ole Brus)) pers:(Nordenskjöld Axel) > (2015-2019) > Lithium for suicide...

  • Brus, Ole,1982-Örebro universitet,Institutionen för medicinska vetenskaper,Clinical Epidemiology and Biostatistics,Orebro Univ, Sweden (author)

Lithium for suicide and readmission prevention after electroconvulsive therapy for unipolar depression : population-based register study

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • 2019-05-27
  • Royal College of Psychiatrists,2019
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-75090
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-75090URI
  • https://doi.org/10.1192/bjo.2019.37DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:143007870URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-164187URI
  • https://gup.ub.gu.se/publication/281965URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • BACKGROUND: Electroconvulsive therapy (ECT) is effective for unipolar depression but relapse and suicide are significant challenges. Lithium could potentially lower these risks, but is used only in a minority of patients.AimsThis study quantifies the effect of lithium on risk of suicide and readmission and identifies factors that are associate with readmission and suicide.METHOD: This population-based register study used data from the Swedish National Quality Register for ECT and other Swedish national registers. Patients who have received ECT for unipolar depression as in-patients between 2011 and 2016 were followed until death, readmission to hospital or the termination of the study at the end of 2016. Cox regression was used to estimate hazard ratios (HR) of readmission and suicide in adjusted models.RESULTS: Out of 7350 patients, 56 died by suicide and 4203 were readmitted. Lithium was prescribed to 638 (9%) patients. Mean follow-up was 1.4 years. Lithium was significantly associated with lower risk of suicide (P = 0.014) and readmission (HR 0.84 95% CI 0.75-0.93). The number needed to be treated with lithium to prevent one readmission was 16. In addition, the following factors were statistically associated with suicide: male gender, being a widow, substance use disorder and a history of suicide attempts. Readmission was associated with young age, being divorced or unemployed, comorbid anxiety disorder, nonpsychotic depression, more severe symptoms before ECT, no improvement with ECT, not receiving continuation ECT or antidepressants, usage of antipsychotics, anxiolytics or benzodiazepines, severity of medication resistance and number of previous admissions.CONCLUSIONS: More patients could benefit from lithium treatment.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Cao, Yang,Associate Professor,1972-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Unit of Biostatistics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden,Clinical Epidemiology and Biostatistics,Orebro Univ, Sweden; Karolinska Inst, Sweden(Swepub:oru)yco (author)
  • Hammar, ÅsaDepartment of Biological and Medical Psychology, University of Bergen, Bergen, Norway; Division of Psychiatry, Haukeland University Hospital, Bergen, Norway,Univ Bergen, Norway; Haukeland Hosp, Norway (author)
  • Landén, Mikael,1966Gothenburg University,Göteborgs universitet,Karolinska Institutet,Gothenburg Univ, Sweden; Karolinska Inst, Sweden,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xlandt (author)
  • Lundberg, JohanKarolinska Institutet,Karolinska Inst, Sweden; Stockholm Cty Council, Sweden (author)
  • Nordanskog, PiaLinköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Region Östergötland, Psykiatriska kliniken inkl beroendekliniken(Swepub:liu)piano33 (author)
  • Nordenskjöld, Axel,1977-Örebro universitet,Institutionen för medicinska vetenskaper,University Health Care Research Centre,Orebro Univ, Sweden(Swepub:oru)alnd (author)
  • Örebro universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

Related titles

  • In:BJPsych Open: Royal College of Psychiatrists5:32056-4724

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