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  • Madrid-Gambin, FranciscoDepartment of Psychiatry, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland (författare)

Integrated Lipidomics and Proteomics Point to Early Blood-Based Changes in Childhood Preceding Later Development of Psychotic Experiences : Evidence From the Avon Longitudinal Study of Parents and Children

  • Artikel/kapitelEngelska2019

Förlag, utgivningsår, omfång ...

  • Elsevier,2019
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-75212
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-75212URI
  • https://doi.org/10.1016/j.biopsych.2019.01.018DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies:Health Research Board  HRA-POR-2013-282  HRBCSA2012/8 European Research Council  647783  724809 European Union FP7 collaborative project METSY  602478 National Institute for Health Research Biomedical Research Centre at University Hospitals Bristol NHS Foundation Trust and the University of Bristol  Irish Health Research Board Clinician Scientist Award  UK Medical Research Council  102215/2/13/2 
  • BACKGROUND: The identification of early biomarkers of psychotic experiences (PEs) is of interest because early diagnosis and treatment of those at risk of future disorder is associated with improved outcomes. The current study investigated early lipidomic and coagulation pathway protein signatures of later PEs in subjects from the Avon Longitudinal Study of Parents and Children cohort.METHODS: Plasma of 115 children (12 years of age) who were first identified as experiencing PEs at 18 years of age (48 cases and 67 controls) were assessed through integrated and targeted lipidomics and semitargeted proteomics approaches. We assessed the lipids, lysophosphatidylcholines (n = 11) and phosphatidylcholines (n = 61), and the protein members of the coagulation pathway (n = 22) and integrated these data with complement pathway protein data already available on these subjects.RESULTS: Twelve phosphatidylcholines, four lysophosphatidylcholines, and the coagulation protein plasminogen were altered between the control and PEs groups after correction for multiple comparisons. Lipidomic and proteomic datasets were integrated into a multivariate network displaying a strong relationship between most lipids that were significantly associated with PEs and plasminogen. Finally, an unsupervised clustering approach identified four different clusters, with one of the clusters presenting the highest case-control ratio (p < .01) and associated with a higher concentration of smaller low-density lipoprotein cholesterol particles.CONCLUSIONS: Our findings indicate that the lipidome and proteome of subjects who report PEs at 18 years of age are already altered at 12 years of age, indicating that metabolic dysregulation may contribute to an early vulnerability to PEs and suggesting crosstalk between these lysophosphatidylcholines, phosphatidylcholines, and coagulation and complement proteins.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Focking, MelanieDepartment of Psychiatry, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland (författare)
  • Sabherwal, SophieDepartment of Psychiatry, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland (författare)
  • Heurich, MeikeSchool of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, United Kingdom (författare)
  • English, Jane A.Department of Psychiatry, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland (författare)
  • O'Gorman, AoifeInstitute of Food and Health, UCD School of Agriculture and Food Science, Dublin, Ireland (författare)
  • Suvitaival, TommiSteno Diabetes Center Copenhagen, Gentofte, Denmark (författare)
  • Ahonen, LindaSteno Diabetes Center Copenhagen, Gentofte, Denmark (författare)
  • Cannon, MaryDepartment of Psychiatry, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland (författare)
  • Lewis, GlynFaculty of Brain Sciences, Division of Psychiatry, University College London, London, United Kingdom (författare)
  • Mattila, IsmoSteno Diabetes Center Copenhagen, Gentofte, Denmark (författare)
  • Scaife, CaitrionaDepartment of Psychiatry, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland (författare)
  • Madden, SeanDepartment of Psychiatry, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland (författare)
  • Hyötyläinen, Tuulia,1971-Örebro universitet,Institutionen för naturvetenskap och teknik,Department of Chemistry(Swepub:oru)tihn (författare)
  • Oresic, Matej,1967-Örebro universitet,Institutionen för medicinska vetenskaper,Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland(Swepub:oru)moc (författare)
  • Zammit, StanleyMRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, United Kingdom; Centre for Academic Mental Health, Bristol Medical School, University of Bristol, Bristol, United Kingdom (författare)
  • Cagney, GerardConway Institute, UCD School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland (författare)
  • Cotter, David R.Department of Psychiatry, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland (författare)
  • Brennan, LorraineInstitute of Food and Health, UCD School of Agriculture and Food Science, Dublin, Ireland (författare)
  • Department of Psychiatry, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, IrelandSchool of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, United Kingdom (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Biological Psychiatry: Elsevier86:1, s. 25-340006-32231873-2402

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