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Effect-Directed Ana...
Effect-Directed Analysis of Ah Receptor-Mediated Potencies in Microplastics Deployed in a Remote Tropical Marine Environment
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- Schönlau, Christine, 1986- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik,MTM Research Centre
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- Larsson, Maria, 1975- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik,MTM Research Centre
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- Dubocq, Florian, 1994- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik,MTM Research Centre
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- Rotander, Anna, 1978- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik,MTM Research Centre
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- Van der Zande, Rene (author)
- Coral Reef Ecosystems Lab and Global Change Institute, The University of Queensland, St. Lucia QLD, Australia
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- Engwall, Magnus, 1965- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik,MTM Research Centre
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- Kärrman, Anna, 1975- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik,MTM Research Centre
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(creator_code:org_t)
- 2019-08-02
- 2019
- English.
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In: Frontiers in Environmental Science. - : Frontiers Media S.A.. - 2296-665X. ; 7
- Related links:
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https://doi.org/10.3...
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https://www.frontier...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- To facilitate the study of potential harmful compounds sorbed to microplastics, an effect-directed analysis using the DR CALUX® assay as screening tool for Aryl hydrocarbon receptor (AhR)-active compounds in extracts of marine deployed microplastics and chemical analysis of hydrophobic organic compounds (HOCs) was conducted. Pellets of three plastic polymers [low-density polyethylene (LDPE), high-density polyethylene (HDPE) and high-impact polystyrene (HIPS)] were deployed at Heron Island in the Great Barrier Reef, Australia, for up to 8 months. Detected AhR-mediated potencies (bio-TEQs) of extracted plastic pellets ranged from 15 to 100 pg/g. Contributions of target HOCs to the overall bioactivities were negligible. To identify the major contributors, remaining plastic pellets were used for fractionation with a gas chromatography (GC) fractionation platform featuring parallel mass spectrometric (MS) detection. The bioassay analysis showed two bioactive fractions of each polymer with bio-TEQs ranging from 5.7 to 14 pg/g. High resolution MS was used in order to identify bioactive compounds in the fractions. No AhR agonists could be identified in fractions of HDPE or LDPE. Via a multivariate statistical approach the polystyrene (PS) trimer 1e- Phenyl-4e-(1- phenylethyl)-tetralin was identified in fractions of HIPS and in fractions of the blank polymer of HIPS.
Subject headings
- NATURVETENSKAP -- Kemi -- Analytisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Analytical Chemistry (hsv//eng)
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
Keyword
- polyethylene
- polystyrene
- PCBs
- reporter gene assay
- fractionation
Publication and Content Type
- ref (subject category)
- art (subject category)
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Schönlau, Christ ...
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Larsson, Maria, ...
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Dubocq, Florian, ...
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Rotander, Anna, ...
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Van der Zande, R ...
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Engwall, Magnus, ...
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Kärrman, Anna, 1 ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Chemical Science ...
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and Analytical Chemi ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Earth and Relate ...
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and Environmental Sc ...
- Articles in the publication
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Frontiers in Env ...
- By the university
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Örebro University