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Adaptation of host transmission cycle during Clostridium difficile speciation

Kumar, Nitin (författare)
Host-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Hinxton, UK
Browne, Hilary P. (författare)
Host-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Hinxton, UK
Viciani, Elisa (författare)
Host-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Hinxton, UK
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Forster, Samuel C. (författare)
Host-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Hinxton, UK; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia; Department of Molecular and Translational Sciences, Monash University, Clayton, Victoria, Australia
Clare, Simon (författare)
Wellcome Sanger Institute, Hinxton, UK
Harcourt, Katherine (författare)
Wellcome Sanger Institute, Hinxton, UK
Stares, Mark D. (författare)
Host-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Hinxton, UK
Dougan, Gordon (författare)
Wellcome Sanger Institute, Hinxton, UK
Fairley, Derek J. (författare)
Belfast Health and Social Care Trust, Belfast, Northern, Ireland
Roberts, Paul (författare)
University of Liverpool, Liverpool, UK
Pirmohamed, Munir (författare)
University of Liverpool, Liverpool, UK
Clokie, Martha R. J. (författare)
Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
Jensen, Mie Birgitte Frid (författare)
Department of Clinical Microbiology, Slagelse Hospital, Slagelse, Denmark
Hargreaves, Katherine R. (författare)
Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
Ip, Margaret (författare)
Department of Microbiology, Chinese University of Hong Kong, Shatin, Hong Kong
Wieler, Lothar H. (författare)
Institute of Microbiology and Epizootics, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany; Robert Koch Institute, Berlin, Germany
Seyboldt, Christian (författare)
Institute of Bacterial Infections and Zoonoses, Federal Research Institute for Animal Health (Friedrich-Loeffler-Institut), Jena, Germany
Norén, Torbjörn, 1955- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Department of Laboratory Medicine, Örebro University Hospital Örebro, Örebro, Sweden
Riley, Thomas V. (författare)
Department of Microbiology, PathWest Laboratory Medicine, Queen Elizabeth II Medical Centre, Nedlands, Western Australia, Australia; School of Pathology & Laboratory Medicine, The University of Western Australia, Nedlands, Western Australia, Australia
Kuijper, Ed J. (författare)
Section Experimental Bacteriology, Department of Medical Microbiology, Leiden University Medical Center, Leiden, Netherlands
Wren, Brendan W. (författare)
Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, University of London, London, UK
Lawley, Trevor D. (författare)
Host-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Hinxton, UK
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 (creator_code:org_t)
2019-08-12
2019
Engelska.
Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 51:9, s. 1315-1320
Relaterad länk:
https://researchonli...
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https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Bacterial speciation is a fundamental evolutionary process characterized by diverging genotypic and phenotypic properties. However, the selective forces that affect genetic adaptations and how they relate to the biological changes that underpin the formation of a new bacterial species remain poorly understood. Here, we show that the spore-forming, healthcare-associated enteropathogen Clostridium difficile is actively undergoing speciation. Through large-scale genomic analysis of 906 strains, we demonstrate that the ongoing speciation process is linked to positive selection on core genes in the newly forming species that are involved in sporulation and the metabolism of simple dietary sugars. Functional validation shows that the new C. difficile produces spores that are more resistant and have increased sporulation and host colonization capacity when glucose or fructose is available for metabolism. Thus, we report the formation of an emerging C. difficile species, selected for metabolizing simple dietary sugars and producing high levels of resistant spores, that is adapted for healthcare-mediated transmission.

Ämnesord

NATURVETENSKAP  -- Biologi -- Evolutionsbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Evolutionary Biology (hsv//eng)

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