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  • Kumar, NitinHost-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Hinxton, UK (author)

Adaptation of host transmission cycle during Clostridium difficile speciation

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • 2019-08-12
  • Nature Publishing Group,2019
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-75827
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-75827URI
  • https://doi.org/10.1038/s41588-019-0478-8DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies:UK Medical Research Council  PF451  MR/K000511/1 Australian National Health and Medical Research Council  1091097  1159239 Victorian Government's Operational Infrastructure Support Program  
  • Bacterial speciation is a fundamental evolutionary process characterized by diverging genotypic and phenotypic properties. However, the selective forces that affect genetic adaptations and how they relate to the biological changes that underpin the formation of a new bacterial species remain poorly understood. Here, we show that the spore-forming, healthcare-associated enteropathogen Clostridium difficile is actively undergoing speciation. Through large-scale genomic analysis of 906 strains, we demonstrate that the ongoing speciation process is linked to positive selection on core genes in the newly forming species that are involved in sporulation and the metabolism of simple dietary sugars. Functional validation shows that the new C. difficile produces spores that are more resistant and have increased sporulation and host colonization capacity when glucose or fructose is available for metabolism. Thus, we report the formation of an emerging C. difficile species, selected for metabolizing simple dietary sugars and producing high levels of resistant spores, that is adapted for healthcare-mediated transmission.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Browne, Hilary P.Host-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Hinxton, UK (author)
  • Viciani, ElisaHost-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Hinxton, UK (author)
  • Forster, Samuel C.Host-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Hinxton, UK; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia; Department of Molecular and Translational Sciences, Monash University, Clayton, Victoria, Australia (author)
  • Clare, SimonWellcome Sanger Institute, Hinxton, UK (author)
  • Harcourt, KatherineWellcome Sanger Institute, Hinxton, UK (author)
  • Stares, Mark D.Host-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Hinxton, UK (author)
  • Dougan, GordonWellcome Sanger Institute, Hinxton, UK (author)
  • Fairley, Derek J.Belfast Health and Social Care Trust, Belfast, Northern, Ireland (author)
  • Roberts, PaulUniversity of Liverpool, Liverpool, UK (author)
  • Pirmohamed, MunirUniversity of Liverpool, Liverpool, UK (author)
  • Clokie, Martha R. J.Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK (author)
  • Jensen, Mie Birgitte FridDepartment of Clinical Microbiology, Slagelse Hospital, Slagelse, Denmark (author)
  • Hargreaves, Katherine R.Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK (author)
  • Ip, MargaretDepartment of Microbiology, Chinese University of Hong Kong, Shatin, Hong Kong (author)
  • Wieler, Lothar H.Institute of Microbiology and Epizootics, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany; Robert Koch Institute, Berlin, Germany (author)
  • Seyboldt, ChristianInstitute of Bacterial Infections and Zoonoses, Federal Research Institute for Animal Health (Friedrich-Loeffler-Institut), Jena, Germany (author)
  • Norén, Torbjörn,1955-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Laboratory Medicine, Örebro University Hospital Örebro, Örebro, Sweden(Swepub:oru)trnn (author)
  • Riley, Thomas V.Department of Microbiology, PathWest Laboratory Medicine, Queen Elizabeth II Medical Centre, Nedlands, Western Australia, Australia; School of Pathology & Laboratory Medicine, The University of Western Australia, Nedlands, Western Australia, Australia (author)
  • Kuijper, Ed J.Section Experimental Bacteriology, Department of Medical Microbiology, Leiden University Medical Center, Leiden, Netherlands (author)
  • Wren, Brendan W.Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, University of London, London, UK (author)
  • Lawley, Trevor D.Host-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Hinxton, UK (author)
  • Host-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Hinxton, UKHost-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Hinxton, UK; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia; Department of Molecular and Translational Sciences, Monash University, Clayton, Victoria, Australia (creator_code:org_t)

Related titles

  • In:Nature Genetics: Nature Publishing Group51:9, s. 1315-13201061-40361546-1718

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