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Circulating metabol...
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Lamichhane, SantoshTurku Bioscience, University of Turku and Åbo Akademi University, Turku, Finland
(författare)
Circulating metabolites in progression to islet autoimmunity and type 1 diabetes
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
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2019-08-23
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Springer,2019
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-75892
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-75892URI
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https://doi.org/10.1007/s00125-019-04980-0DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:142445448URI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding Agencies:Juvenile Diabetes Research Foundation 4-1998-2744-1999-731 4-2001-4352-SRA-2014-159-Q-RSpecial research funds for Oulu University Hospital in Finland Special research funds for Tampere University Hospital in Finland Special research funds for Turku University Hospital in Finland Academy of Finland 250114
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AIMS/HYPOTHESIS: Metabolic dysregulation may precede the onset of type 1 diabetes. However, these metabolic disturbances and their specific role in disease initiation remain poorly understood. In this study, we examined whether children who progress to type 1 diabetes have a circulatory polar metabolite profile distinct from that of children who later progress to islet autoimmunity but not type 1 diabetes and a matched control group.METHODS: We analysed polar metabolites from 415 longitudinal plasma samples in a prospective cohort of children in three study groups: those who progressed to type 1 diabetes; those who seroconverted to one islet autoantibody but not to type 1 diabetes; and an antibody-negative control group. Metabolites were measured using two-dimensional GC high-speed time of flight MS.RESULTS: In early infancy, progression to type 1 diabetes was associated with downregulated amino acids, sugar derivatives and fatty acids, including catabolites of microbial origin, compared with the control group. Methionine remained persistently upregulated in those progressing to type 1 diabetes compared with the control group and those who seroconverted to one islet autoantibody. The appearance of islet autoantibodies was associated with decreased glutamic and aspartic acids.CONCLUSIONS/INTERPRETATION: Our findings suggest that children who progress to type 1 diabetes have a unique metabolic profile, which is, however, altered with the appearance of islet autoantibodies. Our findings may assist with early prediction of the disease.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Kemppainen, EskoTurku Bioscience, University of Turku and Åbo Akademi University, Turku, Finland
(författare)
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Trošt, KajetanSteno Diabetes Center Copenhagen, Gentofte, Denmark
(författare)
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Siljander, HeliChildren’s Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Research Program Unit, University of Helsinki, Helsinki, Finland
(författare)
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Hyöty, HeikkiFaculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland; Fimlab Laboratories, Pirkanmaa Hospital District, Tampere, Finland
(författare)
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Ilonen, JormaImmunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland; Clinical Microbiology, Turku University Hospital, Turku, Finland
(författare)
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Toppari, JormaInstitute of Biomedicine, Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, Finland; Department of Pediatrics, Turku University Hospital, Turku, Finland
(författare)
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Veijola, RiittaDepartment of Pediatrics, PEDEGO Research Unit, Medical Research Centre, University of Oulu, Oulu, Finland; Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland; Department of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden
(författare)
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Hyötyläinen, Tuulia,1971-Örebro universitet,Institutionen för naturvetenskap och teknik(Swepub:oru)tihn
(författare)
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Knip, MikaelChildren’s Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Research Program Unit, University of Helsinki, Helsinki, Finland; Tampere Center for Child Health Research, Tampere University Hospital, Tampere, Finland; Folkhälsan Research Center, Helsinki, Finland
(författare)
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Oresic, Matej,1967-Örebro universitet,Institutionen för medicinska vetenskaper,Turku Bioscience, University of Turku and Åbo Akademi University, Turku, Finland;(Swepub:oru)moc
(författare)
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Turku Bioscience, University of Turku and Åbo Akademi University, Turku, FinlandSteno Diabetes Center Copenhagen, Gentofte, Denmark
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Diabetologia: Springer62:12, s. 2287-22970012-186X1432-0428
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- Av författaren/redakt...
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Lamichhane, Sant ...
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Kemppainen, Esko
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Trošt, Kajetan
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Siljander, Heli
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Hyöty, Heikki
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Ilonen, Jorma
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visa fler...
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Toppari, Jorma
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Veijola, Riitta
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Hyötyläinen, Tuu ...
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Knip, Mikael
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Oresic, Matej, 1 ...
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- Artiklar i publikationen
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Diabetologia
- Av lärosätet
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Örebro universitet
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Karolinska Institutet