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Effect of the basel...
Effect of the baseline Y93H resistance-associated substitution in HCV genotype 3 for direct-acting antiviral treatment : real-life experience from a multicenter study in Sweden and Norway
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- Kjellin, Midori (författare)
- Uppsala universitet,Klinisk mikrobiologi
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- Kileng, Hege (författare)
- Gastroenterology and Nutrition Research Group, Department of Clinical Medicine, UiT the Arctic University of Norway, Tromsø, Norway; Department of Medicine, University Hospital of North Norway, Tromsø, Norway,UiT Arctic Univ Norway, Dept Clin Med, Gastroenterol & Nutr Res Grp, Tromso, Norway;Univ Hosp North Norway, Dept Med, Tromso, Norway
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- Akaberi, Dario (författare)
- Uppsala universitet,Klinisk mikrobiologi
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- Palanisamy, Navaneethan (författare)
- Institute of Biology II, University of Freiburg, Freiburg, Germany; Institute of Biology II, University of Freiburg, Freiburg, Germany,Heidelberg Univ, HBIGS, Heidelberg, Germany;Univ Freiburg, Inst Biol 2, Freiburg, Germany
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- Duberg, Ann-Sofi, Docent, 1957- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Infectious Diseases,Orebro Univ, Fac Med & Hlth, Sch Med Sci, Dept Infect Dis, Orebro, Sweden
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- Danielsson, Astrid (författare)
- Department of Infectious Diseases, Falun Hospital, Falun, Sweden,Falun Cent Hosp, Dept Infect Dis, Falun, Sweden
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- Kristiansen, Magnhild Gangsøy (författare)
- Nordlandssykehuset Bodø, Department of Clinical Medicine (IKM), UiT the Artic University of Tromsø, Tromsø, Norway,UiT Artic Univ Tromso, Dept Clin Med IKM, Nordlandssykehuset Bodo, Tromso, Norway
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- Nöjd, Johan (författare)
- Nordlandssykehuset Bodø, Department of Clinical Medicine (IKM), UiT the Artic University of Tromsø, Tromsø, Norway,UiT Artic Univ Tromso, Dept Clin Med IKM, Nordlandssykehuset Bodo, Tromso, Norway
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- Aleman, Soo (författare)
- Karolinska Institutet
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- Gutteberg, Tore (författare)
- Research Group for Host-Microbe Interactions, Department of Medical Biology, UiT the Arctic University of Norway, Tromsø, Norway; Department of Microbiology and Infection Control, University Hospital of North Norway, Tromsø, Norway,UiT Arctic Univ Norway, Dept Med Biol, Res Grp Host Microbe Interact, Tromso, Norway;Univ Hosp North Norway, Dept Microbiol & Infect Control, Tromso, Norway
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- Goll, Rasmus (författare)
- Gastroenterology and Nutrition Research Group, Department of Clinical Medicine, UiT the Arctic University of Norway, Tromsø, Norway; Department of Medicine, University Hospital of North Norway, Tromsø, Norway,UiT Arctic Univ Norway, Dept Clin Med, Gastroenterol & Nutr Res Grp, Tromso, Norway;Univ Hosp North Norway, Dept Med, Tromso, Norway
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- Lannergård, Anders, 1953- (författare)
- Uppsala universitet,Infektionssjukdomar
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- Lennerstrand, Johan (författare)
- Uppsala universitet,Klinisk mikrobiologi
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(creator_code:org_t)
- 2019-08-19
- 2019
- Engelska.
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Ingår i: Scandinavian Journal of Gastroenterology. - : Taylor & Francis. - 0036-5521 .- 1502-7708. ; 54:8, s. 1042-1050
- Relaterad länk:
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https://doi.org/10.1...
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https://www.tandfonl...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: The NS5A resistance-associated substitution (RAS) Y93H is found quite frequently (5-10%) at baseline in direct-acting antiviral agents (DAA) treatment-naive genotype (GT) 3a patients when studied by the population-sequencing method (cut-off 20%). This RAS may impair HCV DAA treatment response, since it possesses a high fold in vitro resistance to daclatasvir (DCV) and velpatasvir (VEL) in GT 3. We investigated the effect of baseline Y93H in patients with GT 3a infection on treatment outcome, with or without resistance-based DAA-treatment during 2014-2017.Patients/Methods: Treatment in the intervention group (n = 130) was tailored to baseline resistance-findings by population-sequencing method. Detection of baseline Y93H above 20% prompted a prolonged treatment duration of NS5A-inhibitor and sofosbuvir (SOF) and/or addition of ribavirin (RBV). Patients without baseline Y93H in the intervention group and all patients in the control group (n = 78) received recommended standard DAA-treatment.Results: A higher sustained virologic response rate (SVR) in the intervention group was shown compared to the control group at 95.4% (124/130) and 88.5% (69/78), respectively (p = .06). All five patients with baseline Y93H in the intervention group achieved SVR with personalised treatment based on results from resistance testing; either with the addition of RBV or prolonged treatment duration (24w). In the control group, 2/4 patients with Y93H at baseline treated with ledipasvir/SOF/RBV or DCV/SOF without RBV, failed treatment.Conclusion: The results from this real-life study are in accordance with the findings of the randomised controlled trials in 2015 and the EASL-guidelines of 2016, thus, baseline Y93H impacts on DCV and VEL treatment outcome.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- Baseline resistance
- NS5A
- Y93H
- hepatitis C virus
- resistance-associated substitution
- sustained virologic response
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Kjellin, Midori
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Kileng, Hege
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Akaberi, Dario
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Palanisamy, Nava ...
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Duberg, Ann-Sofi ...
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Danielsson, Astr ...
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Kristiansen, Mag ...
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Nöjd, Johan
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Aleman, Soo
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Gutteberg, Tore
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Goll, Rasmus
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Lannergård, Ande ...
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Lennerstrand, Jo ...
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Scandinavian Jou ...
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Örebro universitet
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Uppsala universitet
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Karolinska Institutet