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Increased plasma ca...
Increased plasma cathepsin S and trombospondin-1 in patients with acute ST-segment elevation myocardial infarction
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- Befekadu, Rahel, 1968- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Laboratory Medicine, Section for Transfusion Medicine
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- Christiansen, Kjeld (författare)
- Department of Cardiology, Örebro University Hospital, Örebro, Sweden
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- Larsson, Anders (författare)
- Uppsala universitet,Klinisk kemi
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- Grenegård, Magnus, 1963- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Cardiovascular Research Centre
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(creator_code:org_t)
- Via Medica, 2019
- 2019
- Engelska.
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Ingår i: Cardiology Journal. - : Via Medica. - 1897-5593 .- 1898-018X. ; 26:4, s. 385-393
- Relaterad länk:
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https://doi.org/10.5...
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https://urn.kb.se/re...
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https://doi.org/10.5...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background: The role of cathepsins in the pathological progression of atherosclerotic lesions in ischemic heart disease have been defined in detail more than numerous times. This investigation examined the platelet-specific biomarker trombospondin-1 (TSP-1) and platelet function ex vivo, and compared this with cathepsin S (Cat-S; a biomarker unrelated to platelet activation but also associated this with increased mortality risk) in patients with ST-segment elevation myocardial infarction (STEMI).Methods: The STEMI patients were divided into two groups depending on the degree of coronary vessel occlusion: those with closed (n = 90) and open culprit vessel (n = 40). Cat-S and TSP-1 were analyzed before, 1-3 days after and 3 months after percutanous coronary intervention (PCI).Results: During acute STEMI, plasma TSP-1 was significantly elevated in patients with closed culprit lesions, but rapidly declined after PCI. In fact, TSP-1 after PCI was significantly lower inpatient samples compared to healthy individuals. In comparison, plasma Cat-S was significantly elevated both before and after PCI. In patients with closed culprit lesions, Cat-S was significantly higher compared to patients with open culprit lesions 3 months after PCI. Although troponin-I were higher (p < 0.01) in patients with closed culprit lesion, there was no correlation with Cat-S and TSP-1.Conclusions: Cat-S but not TSP-1 may be a useful risk biomarker in relation to the severity of STEMI. However, the causality of Cat-S as a predictor for long-term mortality in STEMI remains to be ascertained in future studies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- ST-segment elevation myocardial infarction
- cathepsin S
- percutaneous coronary intervention
- platelets
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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