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Hypoglycaemia, irre...
Hypoglycaemia, irrespective of the definition used, is reduced when switching to insulin degludec from other basal insulins in routine clinical care : The ReFLeCT study
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- Feher, M. (författare)
- Beta Cell Diabetes Centre, Chelsea and Westminster Hospital, London, UK; University of Surrey, Guildford, UK
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- Fadini, G.P. (författare)
- Department of Medicine, Division of Metabolic Diseases, University of Padova, Padova, Italy
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- Krarup Hansen, T. (författare)
- Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark
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- Jendle, Johan, 1963- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper
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- Merchante, A. (författare)
- University General Hospital of Castellón, Castellón de la Plana, Spain; Jaume I University, Castellón de la Plana, Spain
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- Koefoed, M.M. (författare)
- Novo Nordisk A/S, Søborg, Denmark
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- Rizi, E.P. (författare)
- Novo Nordisk A/S, Søborg, Denmark
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- Zimmermann, E. (författare)
- Novo Nordisk A/S, Søborg, Denmark
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- de Valk, H.W. (författare)
- Department of Internal Medicine, University Medical Center Utrecht, Utrecht, Netherlands
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(creator_code:org_t)
- Springer, 2019
- 2019
- Engelska.
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Serie: Diabetologia, 0012-186X 1432-0428
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
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- Background and aims: ReFLeCT was a multicentre, prospective, observational study designed to investigate the safety and effectiveness of switching to insulin degludec (degludec) from other basal insulins in patients with type 1 (T1D) or type 2 diabetes (T2D). Few studies had prospectively collected hypoglycaemia data from patient diaries following a switch to degludec in everyday clinical practice. These additional analyses from the ReFLeCT study aimed to assess the effects of switching to degludec according to different hypoglycaemia definitions.Materials and methods: ReFLeCT comprised a 4-week baseline period (pre-switch basal insulin) and a 12-month follow-up period (degludec treatment). The primary endpoint of overall hypoglycaemia reported in patient diaries was reduced during follow-up vs baseline in T1D and T2D with improvement of glycaemic control, as previously reported. Here, hypoglycaemia data from ReFLeCT were analysed using pre-specified and updated (post hoc) American Diabetes Association (ADA) hypoglycaemia definitions. Definitions consisted of: documented asymptomatic and symptomatic, pseudo, probable symptomatic, and Level 1, 2 and 3 (severe) hypoglycaemia (Fig). Hypoglycaemic events were analysed using fully adjusted, negative binomial regression models.Results: In T1D (n=556) and T2D (n=611), estimated rate ratios across the previous and the updated ADA hypoglycaemia definitions were significantly lower during the 12-month follow-up vs the baseline period, except for asymptomatic hypoglycaemia in T1D and Level 3 hypoglycaemia in T2D (due to a low number of severe hypoglycaemic events, no comparable statistics were performed) (Fig). Event rates per patient year were also lower for all definitions during the 12-month follow-up vs the baseline period, except for Level 3 hypoglycaemia in T2D, which marginally increased, although this was likely due to the low number of events in this group.Conclusion: In patients with T1D and T2D, switching to degludec from other basal insulins in routine clinical care is associated with lower rates of hypoglycaemia across a broad range of hypoglycaemia definitions, in combination with improved glycaemic control.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- Av författaren/redakt...
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Feher, M.
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Fadini, G.P.
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Krarup Hansen, T ...
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Jendle, Johan, 1 ...
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Merchante, A.
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Koefoed, M.M.
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visa fler...
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Rizi, E.P.
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Zimmermann, E.
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de Valk, H.W.
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
- Delar i serien
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Diabetologia,
- Av lärosätet
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Örebro universitet