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Genetic and environ...
Genetic and environmental contributions to diagnostic fluctuation in anorexia nervosa and bulimia nervosa
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- Yao, Shuyang (author)
- Karolinska Institutet
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- Larsson, Henrik, 1975- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
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- Norring, Claes (author)
- Karolinska Institutet
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- Birgegård, Andreas (author)
- Karolinska Institutet
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- Lichtenstein, Paul (author)
- Karolinska Institutet
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- DʼOnofrio, Brian M. (author)
- Karolinska Institutet
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- Almqvist, Catarina (author)
- Karolinska Institutet
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- Thornton, Laura M. (author)
- Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
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- Bulik, Cynthia M. (author)
- Karolinska Institutet
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- Kuja-Halkola, Ralf (author)
- Karolinska Institutet
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(creator_code:org_t)
- Cambridge University Press, 2021
- 2021
- English.
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In: Psychological Medicine. - : Cambridge University Press. - 0033-2917 .- 1469-8978. ; 51:1, s. 62-69
- Related links:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
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- BACKGROUND: Anorexia nervosa and bulimia nervosa are two severe eating disorders associated with high premature mortality, suicidal risk and serious medical complications. Transition between anorexia nervosa and bulimia nervosa over the illness course and familial co-aggregation of the two eating disorders imply aetiological overlap. However, genetic and environmental liabilities to the overlap are poorly understood. Quantitative genetic research using clinical diagnosis is needed.METHODS: We acquired a clinical diagnosis of anorexia nervosa (prevalence = 0.90%) and bulimia nervosa (prevalence = 0.48%) in a large population-based sample (N = 782 938) of randomly selected full-sisters and maternal half-sisters born in Sweden between 1970 and 2005. Structural equation modelling was applied to quantify heritability of clinically diagnosed anorexia nervosa and bulimia nervosa and the contributions of genetic and environmental effects on their overlap.RESULTS: The heritability of clinically diagnosed anorexia nervosa and bulimia nervosa was estimated at 43% [95% confidence interval (CI) (36-50%)] and 41% (31-52%), respectively, in the study population, with the remaining variance explained by variance in unique environmental effects. We found statistically significant genetic [0.66, 95% CI (0.49-0.82)] and unique environmental correlations [0.55 (0.43-0.66)] between the two clinically diagnosed eating disorders; and their overlap was about equally explained by genetic and unique environmental effects [co-heritability 47% (35-58%)].CONCLUSIONS: Our study supports shared mechanisms for anorexia nervosa and bulimia nervosa and extends the literature from self-reported behavioural measures to clinical diagnosis. The findings encourage future molecular genetic research on both eating disorders and emphasize clinical vigilance for symptom fluctuation between them.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- Anorexia nervosa
- behavioural genetics
- bulimia nervosa
- clinical diagnosis
- eating disorders
- genetic epidemiology
- medical register
- sibling design
Publication and Content Type
- ref (subject category)
- art (subject category)
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Yao, Shuyang
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Larsson, Henrik, ...
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Norring, Claes
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Birgegård, Andre ...
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Lichtenstein, Pa ...
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DʼOnofrio, Brian ...
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Almqvist, Catari ...
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Thornton, Laura ...
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Bulik, Cynthia M ...
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Kuja-Halkola, Ra ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
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Psychological Me ...
- By the university
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Örebro University
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Karolinska Institutet