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Prognostic value of...
Prognostic value of nuclear FBI-1 in patients with rectal cancer with or without preoperative radiotherapy
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- Wang, Chao-Jie (författare)
- Department of Oncology, Henan Provincial People's Hospital & People's Hospital of Henan University, Zhengzhou, Henan, P.R. China; Department of Oncology, Linköping University, Linköping, Sweden; Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden
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- Chao, Chu-Rui (författare)
- Department of Oncology, Henan Provincial People's Hospital & People's Hospital of Henan University, Zhengzhou, Henan, P.R. China,Henan Univ, Peoples R China
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- Liu, Hui-Min (författare)
- Department of Oncology, Henan Provincial People's Hospital & People's Hospital of Henan University, Zhengzhou, Henan, P.R. China,Henan Univ, Peoples R China
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- Zhu, Yan-Yan (författare)
- Department of Oncology, Henan Provincial People's Hospital & People's Hospital of Henan University, Zhengzhou, Henan, P.R. China,Henan Univ, Peoples R China
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- Adell, Gunnar (författare)
- Linköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US
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- Jarlsfelt, Ingvar (författare)
- Department of Pathology, Ryhov Hospital, Jönköping, Sweden,Ryhov Hosp, Sweden
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- Zhang, Hong, 1957- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Orebro Univ, Sweden
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- Sun, Xiao-Feng (författare)
- Linköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US
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- Wang, Chaojie (författare)
- Linköpings universitet,Institutionen för klinisk och experimentell medicin,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US,Henan Univ, Peoples R China
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Department of Oncology, Henan Provincial People's Hospital & People's Hospital of Henan University, Zhengzhou, Henan, PR. China; Department of Oncology, Linköping University, Linköping, Sweden; Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden Department of Oncology, Henan Provincial People's Hospital & People's Hospital of Henan University, Zhengzhou, Henan, P.R. China (creator_code:org_t)
- 2019-09-19
- 2019
- Engelska.
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Ingår i: Oncology Letters. - : Spandidos Publications. - 1792-1074 .- 1792-1082. ; 18:5, s. 5301-5309
- Relaterad länk:
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https://doi.org/10.3...
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https://www.spandido...
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Factor that binds to the inducer of short transcripts of the human immunodeficiency virus-1 (FBI-1) represents as a crucial gene regulator in colorectal cancer; however, the correlation between FBI-1 and preoperative radiotherapy (RT) in rectal cancer (RC) has not yet been reported. The aim was to detect FBI-1 expression in patients with RC with or without RT, by immunohistochemistry and quantitative polymerase chain reaction, and to analyze its association with clinicopathological features and response to RT. The results from immunohistochemistry analysis (n=139) and reverse transcription-quantitative polymerase chain reaction (n=55) demonstrated that FBI-1 was overexpressed in patients with RC, whether they had received preoperative RT or not. Subsequently, the association between FBI-1 expression, and the clinicopathological features and response to RT in patients with RC was analyzed. Cytoplasmic FBI-1 was upregulated in non-RT (n=77) and RT (n=62) groups (17.7 vs. 74.0%, P<0.001; 41.1 vs. 69.4%, P=0.002, respectively) of patients with RC compared with normal mucosa. However, nuclear FBI-1 was downregulated (75.8 vs. 22.1%, P<0.001; 83.9 vs. 35.5%, P<0.001, respectively) in both groups. RT had no significant effect on FBI-1 expression in RC tissues. Furthermore, nuclear FBI-1 was positively associated with tumor-node-metastasis stage and distant recurrence (P=0.003 and P=0.010, respectively). In patients with stage I, II or III RC, higher nuclear FBI-1 expression was associated with poorer disease-free survival [hazard ratio (HR)=1.934, 95% confidence interval (CI): 1.055-3.579, P=0.033] and overall survival (HR=2.174, 95% CI: 1.102-4.290, P=0.025), independently of sex, age, growth pattern, differentiation and RT. In addition, FBI-1 was positively correlated with numerous biological factors, including p73 [Spearman's correlation coefficient (rs)=0.332, P=0.007], lysyl oxidase (rs=0.234, P=0.043), Wrap53 (rs=-0.425, P=0.0002) and peroxisome proliferator-activated receptor δ (rs=-0.294, P=0.026). In conclusion, the present study demonstrated that nuclear FBI-1 was an independent prognostic factor in patients with RC and correlated with numerous biological factors, which indicated that it may have multiple roles in RC.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Biomarker
- factor that binds to the inducer of short transcripts of the human immunodeficiency virus-1
- preoperative radiotherapy
- prognosis
- rectal cancer
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Wang, Chao-Jie
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Chao, Chu-Rui
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Liu, Hui-Min
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Zhu, Yan-Yan
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Adell, Gunnar
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Jarlsfelt, Ingva ...
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Zhang, Hong, 195 ...
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Sun, Xiao-Feng
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Wang, Chaojie
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Oncology Letters
- Av lärosätet
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Örebro universitet
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Linköpings universitet