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Pregnancy outcomes in inflammatory bowel disease patients treated with vedolizumab, anti-TNF or conventional therapy : results of the European CONCEIVE study

Moens, Annick (författare)
Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium; Department of Chronic Diseases, Metabolism and Ageing, Ku Leuven, Leuven, Belgium
van der Woude, C. Janneke (författare)
Erasmus MC, Rotterdam, Netherlands
Julsgaard, Mette (författare)
Aarhus University Hospital, Aarhus, Denmark
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Humblet, Evelien (författare)
Ziekenhuis Oost‐Limburg ‐ Campus Sint‐Jan, Genk, Belgium
Sheridan, Juliette (författare)
St. Vincent's University Hospital, Dublin, Ireland
Baumgart, Daniel C. (författare)
University of Alberta, Edmonton AB, Canada
De Saint-Joseph, Cyrielle Gilletta (författare)
Hôpital Rangueil, Toulouse, France
Nancey, Stéphane (författare)
CHU Lyon, Lyon, France
Rahier, Jean-Francois (författare)
CHU UCL Namur, Université catholique de Louvain, Yvoir, Belgium
Bossuyt, Peter (författare)
Imeldaziekenhuis, Bonheiden, Belgium
Cremer, Anneline (författare)
Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium
Dewit, Sophie (författare)
Mariaziekenhuis Noord-Limburg, Overpelt, Belgium
Eriksson, Carl, 1981- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län
Hoentjen, Frank (författare)
Radboud University Medical Center, Nijmegen, The Netherland
Krause, Thomas (författare)
Opernstrasse, Kassel, Germany
Louis, Edouard (författare)
CHU Liege, Liege, Belgium
Macken, Elisabeth (författare)
Universiteit zieken‐huis Antwerpen UZA, Belgium
Milenkovic, Zoran (författare)
Military Medical Academy Belgrade, Belgrade, Serbia
Nijs, Jochen (författare)
Sint‐Trudo Ziekenhuis, Sint‐Truiden, Belgium
Posen, Annelies (författare)
AZ Vesalius, Tongeren, Belgium
Van Hootegem, Anneleen (författare)
AZ Klina, Brasschaat, Belgium
Van Moerkercke, Wouter (författare)
AZ Groeninge, Kortrijk, Belgium
Vermeire, Severine (författare)
Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium; Department of Chronic Diseases, Metabolism and Ageing, Ku Leuven, Leuven, Belgium
Shitrit, Ariella Bar-Gil (författare)
Shaare Zedek Medical Center, Hebrew University Jerusalem, Jerusalem, Israel
Ferrante, Marc (författare)
Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium; Department of Chronic Diseases, Metabolism and Ageing, Ku Leuven, Leuven, Belgium
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 (creator_code:org_t)
2019-11-06
2020
Engelska.
Ingår i: Alimentary Pharmacology and Therapeutics. - : Blackwell Publishing. - 0269-2813 .- 1365-2036. ; 51:1, s. 129-138
Relaterad länk:
https://doi.org/10.1...
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https://orbi.uliege....
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background: Women with inflammatory bowel diseases (IBD) often receive biologicals during pregnancy to maintain disease remission. Data on outcome of vedolizumab-exposed pregnancies (VDZE) are sparse.Aims: The aim was to assess pregnancy and child outcomes of VDZE pregnancies and to compare these results to anti-TNF exposed (TNFE) or both immunomodulatory and biologic unexposed (CON IBD) pregnancies.Methods: A retrospective multicentre case-control observational study was performed.Results: VDZE group included 79 pregnancies in 73 IBD women. The TNFE and CON IBD group included 186 pregnancies (162 live births) in 164 IBD women and 184 pregnancies (163 live births) in 155 IBD women, respectively. At conception, cases more often had active disease ([VDZE: 36% vs TNFE: 17%, P = .002] and [VDZE: 36% vs CON IBD: 24%, P = .063]). No significant difference in miscarriage rates were found between groups (VDZE and TNFE: 16% vs 13%, P = .567; VDZE and CON IBD: 16% vs 10%, P = .216). In live-born infants, median gestational age and birthweight were similar between groups. Median Apgar score at birth was numerically equal. Prematurity was similar in the VDZE group compared to the control groups, even when correcting for disease activity during pregnancy. The frequency of congenital anomalies was comparable between groups as were the percentages of breastfed babies. During the first year of life, no malignancies were reported and infants' infection risk did not significantly differ between groups.Conclusion: No new safety signal was detected in VDZE pregnancies although larger, prospective studies are required for confirmation.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Gastroenterologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)

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