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The familial co-agg...
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Song, HuanCenter of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
(author)
The familial co-aggregation of stress-related disorders and autoimmune diseases
- Article/chapterEnglish2019
Publisher, publication year, extent ...
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2019-10-22
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Springer,2019
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:oru-78629
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-78629URI
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https://doi.org/10.1007/s10519-019-09973-8DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:vet swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background: Evidence has emerged indicating a role of stress-related disorders in the development of autoimmune diseases. However, it remains unknown whether genetic components contribute to the observed association. We therefore investigated the co-aggregation of stress-related disorders and autoimmune diseases in individuals and their family members in the Swedish population.Methods: We identified 4,123,631 individuals born in Sweden between 1953 and 1993. Based on information from the Multi-Generation Register, we conducted cohorts of relatives of varying relatedness. Logistic regression was used to estimate the association between clinical ascertained stress-related disorders (i.e., acute stress reaction, posttraumatic stress disorder [PTSD], adjustment disorder, and other severe stress reactions) and autoimmune diseases (36 different types) in individuals and in families, presenting relative risks as odds ratios (ORs).Results: Individuals with stress-related disorder were at high er risk of having autoimmune diseases compared with individuals who did nothave stress-related disorder (OR = 1.66, 95% confidence intervals (CI) 1.63–1.69). Within families, the association seemed strongest between monozygotic twins (OR = 1.47, 95% CI 1.07–2.03), and then decreased with descending dyads of familial/genetic relatedness ̄OR was 1.28 (95% CI 0.97–1.67), 1.16 (95% CI 1.14–1.18), 1.05 (95% CI 1.02–1.09), 1.06 (95% CI 1.03–1.10), 1.05 (95% CI 1.04–1.06), and 1.00 (95% CI 0.98–1.04) for dizygotic twins, full siblings, maternal half siblings, paternal half siblings, full cousins, and half cousins, respectively. Further analyses on PTSD and autoimmune diseases obtained similar estimates.Conclusion: The pattern of the association across twin zygosity and varying familial relatedness supports the hypothesis of a genetic overlap between stress-related disorders and autoimmune diseases which warrants further exploration.
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Yao, YuyangKarolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, Sweden
(author)
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Fang, FangKarolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, Sweden
(author)
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Lichtenstein, PaulKarolinska Institutet, Stockholm, Sweden
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D'Onofrio, BrianIndiana University, Bloomingto IN, USA
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Almqvist, CatarinaKarolinska Institutet, Stockholm, Sweden
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Larsson, Henrik,1975-Örebro universitet,Institutionen för medicinska vetenskaper(Swepub:oru)hiln
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Valdimarsdottir, UnnurCenter of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
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Center of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik, IcelandKarolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, Sweden
(creator_code:org_t)
Related titles
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In:Behavior Genetics: Springer49:6, s. 539-5400001-82441573-3297
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