The familial co-aggregation of stress-related disorders and autoimmune diseases

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Song, HuanCenter of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik, Iceland (author)

The familial co-aggregation of stress-related disorders and autoimmune diseases

Article/chapterEnglish2019

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2019-10-22
Springer,2019
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LIBRIS-ID:oai:DiVA.org:oru-78629
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-78629URI
https://doi.org/10.1007/s10519-019-09973-8DOI

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Language:English
Summary in:English

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Background: Evidence has emerged indicating a role of stress-related disorders in the development of autoimmune diseases. However, it remains unknown whether genetic components contribute to the observed association. We therefore investigated the co-aggregation of stress-related disorders and autoimmune diseases in individuals and their family members in the Swedish population.Methods: We identified 4,123,631 individuals born in Sweden between 1953 and 1993. Based on information from the Multi-Generation Register, we conducted cohorts of relatives of varying relatedness. Logistic regression was used to estimate the association between clinical ascertained stress-related disorders (i.e., acute stress reaction, posttraumatic stress disorder [PTSD], adjustment disorder, and other severe stress reactions) and autoimmune diseases (36 different types) in individuals and in families, presenting relative risks as odds ratios (ORs).Results: Individuals with stress-related disorder were at high er risk of having autoimmune diseases compared with individuals who did nothave stress-related disorder (OR = 1.66, 95% confidence intervals (CI) 1.63–1.69). Within families, the association seemed strongest between monozygotic twins (OR = 1.47, 95% CI 1.07–2.03), and then decreased with descending dyads of familial/genetic relatedness ̄OR was 1.28 (95% CI 0.97–1.67), 1.16 (95% CI 1.14–1.18), 1.05 (95% CI 1.02–1.09), 1.06 (95% CI 1.03–1.10), 1.05 (95% CI 1.04–1.06), and 1.00 (95% CI 0.98–1.04) for dizygotic twins, full siblings, maternal half siblings, paternal half siblings, full cousins, and half cousins, respectively. Further analyses on PTSD and autoimmune diseases obtained similar estimates.Conclusion: The pattern of the association across twin zygosity and varying familial relatedness supports the hypothesis of a genetic overlap between stress-related disorders and autoimmune diseases which warrants further exploration.

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MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Psykiatri hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Psychiatry hsv//eng
SAMHÄLLSVETENSKAP Psykologi hsv//swe
SOCIAL SCIENCES Psychology hsv//eng

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Yao, YuyangKarolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, Sweden (author)
Fang, FangKarolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, Sweden (author)
Lichtenstein, PaulKarolinska Institutet, Stockholm, Sweden (author)
D'Onofrio, BrianIndiana University, Bloomingto IN, USA (author)
Almqvist, CatarinaKarolinska Institutet, Stockholm, Sweden (author)
Larsson, Henrik,1975-Örebro universitet,Institutionen för medicinska vetenskaper(Swepub:oru)hiln (author)
Valdimarsdottir, UnnurCenter of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik, Iceland (author)
Center of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik, IcelandKarolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, Sweden (creator_code:org_t)

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In:Behavior Genetics: Springer49:6, s. 539-5400001-82441573-3297

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

SOCIAL SCIENCES: SOCIAL SCIENCES; and Psychology

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