Pulmonary phthalate exposure and asthma - is PPAR a plausible mechanistic link?

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Bölling, AnetteDivision of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway (author)

Pulmonary phthalate exposure and asthma - is PPAR a plausible mechanistic link?

Article/chapterEnglish2013

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Universität Mainz,2013
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LIBRIS-ID:oai:DiVA.org:oru-79020
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-79020URI
https://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-43903URI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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Due to their extensive use as plasticisers in numerous consumer products, phthalates have become ubiquitous environmental contaminants. An increasing number of epidemiological studies suggest that exposure to phthalates may be associated with worsening or development of airway diseases. Peroxisome Proliferation Activated Receptors (PPAR)s, identified as important targets for phthalates in early studies in rodent liver, have been suggested as a possible mechanistic link. In this review we discuss the likelihood of an involvement of PPARs in asthma development and exacerbation due to pulmonary phthalate exposure. First, we go through the literature on indoor air levels of phthalates and pulmonary phthalate kinetics. These data are then used to estimate the pulmonary phthalate levels due to inhalation exposure. Secondly, the literature on phthalate-induced activation or modulation of PPARs is summarized. Based on these data, we discuss whether pulmonary phthalate exposure is likely to cause PPAR activation, and if this is a plausible mechanism for adverse effects of phthalates in the lung. It is concluded that the pulmonary concentrations of some phthalates may be sufficient to cause a direct activation of PPARs. Since PPARs mainly mediate antiinflammatory effects in the lungs, a direct activation is not a likely molecular mechanism for adverse effects of phthalates. However, possible modulatory effects of phthalates on PPARs deserve further investigation, including partial antagonist effects and/or cross talk with other signalling pathways. Moreover other mechanisms, including interactions between phthalates and other receptors, could also contribute to possible adverse pulmonary effects of phthalates.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Public Health, Global Health, Social Medicine and Epidemiology hsv//eng
Phthalates
asthma
Peroxisome Proliferation Activated Receptors
molecular mechanism
Public Health Science
Folkhälsovetenskap

Added entries (persons, corporate bodies, meetings, titles ...)

Holme, JörnDivision of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway (author)
Bornehag, Carl-Gustaf,1957-Karlstads universitet,Institutionen för hälsovetenskaper (from 2013)(Swepub:kau)caguborn (author)
Nygaard, Unni CDivision of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway (author)
Bertelsen, RandiDivision of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway (author)
Nånberg, Eewa,1957-Karlstads universitet,Institutionen för hälsovetenskaper (from 2013)(Swepub:kau)eewanan (author)
Bodin, JohannaDivision of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway (author)
Sakhi, Amrit KaurDivision of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway (author)
Thomsen, CathrineDivision of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway (author)
Becher, RuneDivision of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway (author)
Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, NorwayInstitutionen för hälsovetenskaper (from 2013) (creator_code:org_t)

Related titles

In:EXCLI Journal: Universität Mainz12, s. 733-7591611-2156

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https://www.excli.de/index.php/excli/article/view/1189Free full text at publisher
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662182/?report=readerFulltext
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-79020
https://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-43903

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By the author/editor: Bölling, Anette; Holme, Jörn; Bornehag, Carl-G ...; Nygaard, Unni C; Bertelsen, Randi; Nånberg, Eewa, 1 ...; show more...; Bodin, Johanna; Sakhi, Amrit Kau ...; Thomsen, Cathrin ...; Becher, Rune; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Public Health Gl ...

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