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  • Lleó, AlbertoHospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain; Centre of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain (författare)

Longitudinal cerebrospinal fluid biomarker trajectories along the Alzheimer's disease continuum in the BIOMARKAPD study

  • Artikel/kapitelEngelska2019

Förlag, utgivningsår, omfång ...

  • 2019-04-06
  • Elsevier,2019
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-79152
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-79152URI
  • https://doi.org/10.1016/j.jalz.2019.01.015DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:141093579URI
  • https://gup.ub.gu.se/publication/281592URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies:Ministry of Health, Italy, Appeared in article as Italian Ministry of HealthNetherlands Organization for Health Research and Development, Appeared in article as Netherlands Organization for Health, Research and Development (ZonMw)Instituto de Salud Carlos III, Appeared in article as Instituto de Salud Carlos III, Grant numbers PI14/1561, PI17/1895Fondo Europeo de Desarrollo Regional (FEDER), Union Europea, "Una manera de hacer Europa"Federal Ministry of Education & Research (BMBF), Appeared in article as Bundesministerium fur Bildung und Forschung (BMBF), GermanySwedish Research Council, Appeared in article as Swedish Research CouncilInnovation Fund Denmark, Grant number 0603-00470BFonds de Recherche du Quebec-Sante (FRQS)J. L. Levesque Foundation  Department of Health of the Basque Government, Grant number 2016111096Instituto de Salud Carlos III, Appeared in article as Carlos III Institute of Health, Grant number PI15/00919"Obra Social Kutxa Fundazioa"European Research Council (ERC), Appeared in article as European Research Council, Grant number 681712Swedish Research Council, Appeared in article as Swedish Research Council, Grant number 2013-2546Torsten Soderberg Foundation at the Royal Swedish Academy of Sciences  European Union (EU), Appeared in article as European Commission as part of the 6th Framework Program, Grant number 37670
  • INTRODUCTION: Within-person trajectories of cerebrospinal fluid (CSF) biomarkers in Alzheimer's disease (AD) are not well defined.METHODS: We included 467 subjects from the BIOMARKAPD study with at least two serial CSF samples. Diagnoses were subjective cognitive decline (n = 75), mild cognitive impairment (n = 128), and AD dementia (n = 110), and a group of cognitively unimpaired subjects (n = 154) were also included. We measured baseline and follow-up CSF levels of total tau (t-tau), phosphorylated tau (p-tau), YKL-40, and neurofilament light (NfL). Median CSF sampling interval was 2.1 years.RESULTS: CSF levels of t-tau, p-tau, NfL, and YKL-40 were 2% higher per each year of baseline age in controls (P <.001). In AD, t-tau levels were 1% lower (P <.001) and p-tau levels did not change per each year of baseline age. Longitudinally, only NfL (P <.001) and YKL-40 (P <.02) increased during the study period.DISCUSSION: All four CSF biomarkers increase with age, but this effect deviates in AD for t-tau and p-tau.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Alcolea, DanielHospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain; Centre of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain (författare)
  • Martínez-Lage, PabloCenter for Research and Advanced Therapies, Fundación CITA-alzheimer Fundazioa, San Sebastian, Spain (författare)
  • Scheltens, PhilipAmsterdam UMC, Department of Neurology and Alzheimer Center, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands (författare)
  • Parnetti, LucillaCentre for Memory Disturbances, Section of Neurology, Lab of Clinical Neurochemistry, University of Perugia, Perugia, Italy (författare)
  • Poirier, JudesKarolinska Institutet (författare)
  • Simonsen, Anja H.Danish Dementia Research Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark (författare)
  • Verbeek, Marcel M.Department of Neurology, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Center, Nijmegen, the Netherlands; Department of Laboratory Medicine, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Center, Nijmegen, the Netherlands (författare)
  • Rosa-Neto, PedroCentre for the Studies on the Prevention of Alzheimer's Disease, Douglas Mental Health University Institute, Montréal, QC, Canada (författare)
  • Slot, Rosalinde E.R.Amsterdam UMC, Department of Neurology and Alzheimer Center, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands (författare)
  • Tainta, MikelCenter for Research and Advanced Therapies, Fundación CITA-alzheimer Fundazioa, San Sebastian, Spain (författare)
  • Izaguirre, AndreaCenter for Research and Advanced Therapies, Fundación CITA-alzheimer Fundazioa, San Sebastian, Spain (författare)
  • Reijs, Babette L.R.Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, the Netherlands (författare)
  • Farotti, LuciaCentre for Memory Disturbances, Section of Neurology, Lab of Clinical Neurochemistry, University of Perugia, Perugia, Italy (författare)
  • Tsolaki, Magda1st Department of Neurology, AHEPA University Hospital, Aristotle University of Thessaloniki, Makedonia, Greece; Alzheimer Hellas, Thessaloniki, Greece (författare)
  • Vandenbergue, RikUniversity Hospital Leuven, Leuven, Belgium; Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium (författare)
  • Freund-Levi, Yvonne,1956-Department of Neurobiology, Care Sciences and Society, Karolinska Institutet Center for Alzheimer Research, Division of Clinical Geriatrics, Huddinge; Department of Old Age Psychiatry, Psychology and Neuroscience, King's College London, London, UK(Swepub:oru)yfi (författare)
  • Verhey, Frans R.J.Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, the Netherlands (författare)
  • Clarimón, JordiHospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain; Centre of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain (författare)
  • Fortea, JuanHospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain; Centre of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain (författare)
  • Frolich, LutzCentral Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany (författare)
  • Santana, IsabelDementia Clinic, Centro Hospitalar e Universitário de Coimbra and Faculty of Medicine, Universidade de Coimbra, Coimbra, Portugal (författare)
  • Molinuevo, José LuisICN Hospital Clinic i Universitari, Barcelona, Spain (författare)
  • Lehmann, SylvainUniv Montpellier, CHU Montpellier, Montpellier, France (författare)
  • Visser, Pieter J.Amsterdam UMC, Department of Neurology and Alzheimer Center, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, the Netherlands (författare)
  • Teunissen, Charlotte E.Amsterdam UMC, Department of Neurology and Alzheimer Center, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands (författare)
  • Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe (författare)
  • Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka (författare)
  • Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain; Centre of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, SpainCenter for Research and Advanced Therapies, Fundación CITA-alzheimer Fundazioa, San Sebastian, Spain (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Alzheimer's & Dementia: Elsevier15:6, s. 742-7531552-52601552-5279

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