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  • Kim, MinInstitute of Pharmaceutical Science, King's College London, London, UK; Steno Diabetes Center Copenhagen, Gentofte, Denmark (författare)

Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort

  • Artikel/kapitelEngelska2019

Förlag, utgivningsår, omfång ...

  • 2019-05-08
  • Elsevier,2019
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-79153
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-79153URI
  • https://doi.org/10.1016/j.jalz.2019.03.004DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:141071627URI
  • https://gup.ub.gu.se/publication/280954URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies:Innovative Medicines Initiative Joint Undertaking under EMIF, Grant number 115372European Union (EU), Appeared in article as European UnionEFPIA companies  European Commission Joint Research Centre, Appeared in article as European Commission, Grant number QLRT-2001-245537670Department of Health of the Basque Government, Grant number  17.0.1.08.12.0000.2.454.01.41142.001.HUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA, Appeared in article as National Institutes of Health, Grant number R15-GM107864
  • INTRODUCTION: A critical and as-yet unmet need in Alzheimer's disease (AD) is the discovery of peripheral small molecule biomarkers. Given that brain pathology precedes clinical symptom onset, we set out to test whether metabolites in blood associated with pathology as indexed by cerebrospinal fluid (CSF) AD biomarkers.METHODS: This study analyzed 593 plasma samples selected from the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery study, of individuals who were cognitively healthy (n = 242), had mild cognitive impairment (n = 236), or had AD-type dementia (n = 115). Logistic regressions were carried out between plasma metabolites (n = 883) and CSF markers, magnetic resonance imaging, cognition, and clinical diagnosis.RESULTS: Eight metabolites were associated with amyloid β and one with t-tau in CSF, these were primary fatty acid amides (PFAMs), lipokines, and amino acids. From these, PFAMs, glutamate, and aspartate also associated with hippocampal volume and memory.DISCUSSION: PFAMs have been found increased and associated with amyloid β burden in CSF and clinical measures.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Snowden, StuartInstitute of Pharmaceutical Science, King's College London, London, UK; Institute of Metabolic Science, University of Cambridge, Cambridge, UK; Department of Biochemistry, University of Cambridge, Cambridge, UK (författare)
  • Suvitaival, TommiSteno Diabetes Center Copenhagen, Gentofte, Denmark (författare)
  • Ali, AshfaqSteno Diabetes Center Copenhagen, Gentofte, Denmark (författare)
  • Merkler, David JDepartment of Chemistry, University of South Florida, Tampa, FL, USA (författare)
  • Ahmad, TahminaInstitute of Pharmaceutical Science, King's College London, London, UK (författare)
  • Westwood, SarahDepartment of Psychiatry, University of Oxford, Oxford, UK (författare)
  • Baird, AlisonDepartment of Psychiatry, University of Oxford, Oxford, UK (författare)
  • Proitsi, PetroulaKarolinska Institutet (författare)
  • Nevado-Holgado, AlejoDepartment of Psychiatry, University of Oxford, Oxford, UK (författare)
  • Hye, AbdulSteno Diabetes Center Copenhagen, Gentofte, Denmark (författare)
  • Bos, IsabelleAlzheimer Centrum Limburg, Maastricht University, Maastricht, The Netherlands (författare)
  • Vos, StephanieAlzheimer Centrum Limburg, Maastricht University, Maastricht, The Netherlands (författare)
  • Vandenberghe, RikUniversity Hospital Leuven, Leuven, Belgium (författare)
  • Teunissen, CharlotteNeurochemistry Laboratory and Biobank, Department of Clinical Chemistry, Amsterdam University Medical Centers, Amsterdam Neuroscience, Amsterdam, The Netherlands (författare)
  • Ten Kate, MaraNeurochemistry Laboratory and Biobank, Department of Clinical Chemistry, Amsterdam University Medical Centers, Amsterdam Neuroscience, Amsterdam, The Netherlands (författare)
  • Scheltens, PhilipDepartment of Neurology, Alzheimer Center, Amsterdam University Medical Centers, Amsterdam, The Netherlands (författare)
  • Gabel, SilvyUniversity Hospital Leuven, Leuven, Belgium; Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium (författare)
  • Meersmans, KarenUniversity Hospital Leuven, Leuven, Belgium; Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium (författare)
  • Blin, OlivierService de Pharmacologie Clinique et Pharmacovigilance, Institut de Neurosciences des Systèmes, Aix Marseille University, APHM, INSERM, Marseille, France (författare)
  • Richardson, JillNeurosciences Therapeutic Area, GlaxoSmithKline R&D, Stevenage, UK (författare)
  • De Roeck, EllenInstitute Born-Bunge, University of Antwerp, Antwerp, Belgium (författare)
  • Sleegers, KristelInstitute Born-Bunge, University of Antwerp, Antwerp, Belgium; Neurodegenerative Brain Diseases Group, Center for Molecular Neurology, VIB, Flanders, Belgium (författare)
  • Bordet, RégisUniversity of Lille, INSERM, CHU, Degenerative and Vascular Cognitive Disorders, Lille, Lille, France (författare)
  • Rami, LorenaAlzheimer's Disease and Other Cognitive Disorders Unit, Hospital Clinic-IDIBAPS, Barcelona, Spain (författare)
  • Kettunen, PetronellaGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xketpe (författare)
  • Tsolaki, MagdaFirst Department of Neurology, AHEPA University Hospital, Makedonia, Thessaloniki, Greece (författare)
  • Verhey, FransAlzheimer Centrum Limburg, Maastricht University, Maastricht, The Netherlands (författare)
  • Sala, IsabelMemory Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain (författare)
  • Lléo, AlbertoMemory Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain (författare)
  • Peyratout, GwendolineUniversity Hospital of Lausanne, Lausanne, Switzerland (författare)
  • Tainta, MikelCITA-Alzheimer Foundation, San Sebastian, Spain (författare)
  • Johannsen, PeterDanish Dementia Research Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark (författare)
  • Freund-Levi, Yvonne,1956-Department of Neurobiology, Caring Sciences and Society (NVS), Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden; Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden(Swepub:oru)yfi (författare)
  • Frölich, LutzDepartment of Geriatric Psychiatry, Zentralinstitut für Seelische Gesundheit, University of Heidelberg, Mannheim, Germany (författare)
  • Dobricic, ValerijaLübeck Interdisciplinary Platform for Genome Analytics, University of Lübeck, Germany (författare)
  • Engelborghs, SebastiaanInstitute Born-Bunge, University of Antwerp, Antwerp, Belgium; Lübeck Interdisciplinary Platform for Genome Analytics, University of Lübeck, Germany; Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, Antwerp, Belgium (författare)
  • Frisoni, Giovanni BUniversity of Geneva, Geneva, Switzerland (författare)
  • Molinuevo, José LAlzheimer's Disease and Other Cognitive Disorders Unit, Hospital Clinic-IDIBAPS, Barcelona, Spain; Barcelona Beta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain (författare)
  • Wallin, Anders,1950Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xwaand (författare)
  • Popp, JuliusUniversity Hospital of Lausanne, Lausanne, Switzerland; Geriatric Psychiatry, Department of Mental Health and Psychiatry, Geneva University Hospitals, Geneva, Switzerland (författare)
  • Martinez-Lage, PabloCITA-Alzheimer Foundation, San Sebastian, Spain (författare)
  • Bertram, LarsUniversity of Lübeck, Lübeck, Germany (författare)
  • Barkhof, FrederikNeurochemistry Laboratory and Biobank, Department of Clinical Chemistry, Amsterdam University Medical Centers, Amsterdam Neuroscience, Amsterdam, The Netherlands (författare)
  • Ashton, Nicholas J.Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xashtn (författare)
  • Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka (författare)
  • Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe (författare)
  • Streffer, JohannesExperimental Medicine, Janssen Pharmaceutical Companies, Beerse, Belgium (författare)
  • Visser, Pieter JAlzheimer Centrum Limburg, Maastricht University, Maastricht, The Netherlands; Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry, Amsterdam University Medical Centers, Amsterdam Neuroscience, Amsterdam, The Netherlands (författare)
  • Lovestone, SimonDepartment of Psychiatry, University of Oxford, Oxford, UK (författare)
  • Legido-Quigley, CristinaInstitute of Pharmaceutical Science, King's College London, London, UK; Steno Diabetes Center Copenhagen, Gentofte, Denmark (författare)
  • Institute of Pharmaceutical Science, King's College London, London, UK; Steno Diabetes Center Copenhagen, Gentofte, DenmarkInstitute of Pharmaceutical Science, King's College London, London, UK; Institute of Metabolic Science, University of Cambridge, Cambridge, UK; Department of Biochemistry, University of Cambridge, Cambridge, UK (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Alzheimer's & Dementia: Elsevier15:6, s. 817-8271552-52601552-5279

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