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A metabolite-based ...
A metabolite-based machine learning approach to diagnose Alzheimer-type dementia in blood : Results from the European Medical Information Framework for Alzheimer disease biomarker discovery cohort
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- Stamate, Daniel (författare)
- Division of Population Health, Health Services Research and Primary Care, University of Manchester, Manchester, UK; Data Science & Soft Computing Lab, London, UK; Computing Department, Goldsmiths College, University of London, London, UK
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- Kim, Min (författare)
- Steno Diabetes Center Copenhagen, Gentofte, Denmark
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- Proitsi, Petroula (författare)
- Karolinska Institutet
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- Weestwood, Sarah (författare)
- Department of Psychiatry, University of Oxford, Oxford, UK
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- Baird, Alison (författare)
- Department of Psychiatry, University of Oxford, Oxford, UK
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- Nevado-Holgado, Alejo (författare)
- Department of Psychiatry, University of Oxford, Oxford, UK
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- Hye, Abdul (författare)
- Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK
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- Bos, Isabelle (författare)
- Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlands; Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands
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- Vos, Stephanie J.B. (författare)
- Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlands
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- Vandenberghe, Rik (författare)
- Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands
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- Teunissen, Charlotte E. (författare)
- Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands
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- Kate, Mara Ten (författare)
- Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands; Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands
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- Scheltens, Philip (författare)
- Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands
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- Gabel, Silvy (författare)
- Department of Clinical Chemistry, Neurochemistry Laboratory, Amsterdam Neuroscience, Amsterdam University Medical Centers, Vrije Universiteit, the Netherlands; University Hospital Leuven, Leuven, Belgium; Department of Neurosciences, Laboratory for Cognitive Neurology, KU, Leuven, Belgium
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- Meersmans, Karen (författare)
- University Hospital Leuven, Leuven, Belgium; Department of Neurosciences, Laboratory for Cognitive Neurology, KU, Leuven, Belgium
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- Blin, Olivier (författare)
- AIX Marseille University, INS, Ap‐hm, Marseille, France
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- Richardson, Jill (författare)
- Neurosciences Therapeutic Area GlaxoSmithKline R&D, Stevenage, UK
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- De Roeck, Ellen (författare)
- Faculty of Psychology & Educational Sciences Vrije, Universiteit Brussel (VUB), Brussels, Belgium; Reference Center for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerp, Belgium; Institute Born‐Bunge, University of Antwerp, Antwerp, Belgium
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- Engelborghs, Sebastiaan (författare)
- Reference Center for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerp, Belgium; Institute Born‐Bunge, University of Antwerp, Antwerp, Belgium; Department of Neurology, UZ Brussel and Center for Neurosciences, Vrije Universiteit Brussel (VUB), Brussels, Belgium
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- Sleegers, Kristel (författare)
- Institute Born‐Bunge, University of Antwerp, Antwerp, Belgium; Neurodegenerative Brain Diseases Group, Center for Molecular Neurology, VIB, Belgium
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- Bordet, Régis (författare)
- University of Lille, Inserm, CHU Lille, Lille, France
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- Ramit, Lorena (författare)
- Alzheimer's Disease & Other Cognitive Disorders Unit, Hospital Clínic‐IDIBAPS, Barcelona, Spain
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- Kettunen, Petronella (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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- Tsolaki, Magda (författare)
- 1st Department of Neurology, AHEPA University Hospital, Makedonia, Thessaloniki, Greece
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- Verhey, Frans (författare)
- Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlands
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- Alcolea, Daniel (författare)
- Memory Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
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- Lléo, Alberto (författare)
- Memory Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
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- Peyratout, Gwemdoline (författare)
- University Hospital of Lausanne, Lausanne, Switzerland
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- Tainta, Mikael (författare)
- Center for Research and Advanced Therapies, Fundacion CITA‐alzheimer Fundazioa, Donostia/San Sebastian, Spain
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- Johannsen, Peter (författare)
- Danish Dementia Research Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
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- Freund-Levi, Yvonne, 1956- (författare)
- Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK; Department of Neurobiology, Caring Sciences and Society (NVS), Division of Clinical Geriatrics, Karolinska Institute, Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden
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- Frölich, Lutz (författare)
- Department of Geriatric Psychiatry, Zentralinstitut für Seelische Gesundheit, University of Heidelberg, Mannheim, Germany
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- Dobricic, Valerija (författare)
- Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and Cardiogenetics, University of Lübeck, Lübeck, Germany
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- Frisoni, Giovanni B. (författare)
- University of Geneva, Geneva, Switzerland; IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
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- Molinuevo, José L. (författare)
- University of Lille, Inserm, CHU Lille, Lille, France; Barcelona Beta Brain Research Center, Unversitat Pompeu Fabra, Barcelona, Spain
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- Wallin, Anders, 1950 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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- Popp, Julius (författare)
- University Hospital of Lausanne, Lausanne, Switzerland; Department of Mental Health and Psychiatry, Geriatric Psychiatry, Geneva University Hospitals, Geneva, Switzerland
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- Martinez-Lage, Pablo (författare)
- Center for Research and Advanced Therapies, Fundacion CITA‐alzheimer Fundazioa, Donostia/San Sebastian, Spain
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- Bertram, Lars (författare)
- Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and Cardiogenetics, University of Lübeck, Lübeck, Germany; Department of Psychology, University of Oslo, Oslo, Norway
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- Blennow, Kaj, 1958 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Zetterberg, Henrik, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Streffer, Johannes (författare)
- Reference Center for Biological Markers of Dementia (BIODEM), Institute Born‐Bunge, University of Antwerp, Antwerp, Belgium
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- Visser, Pieter J. (författare)
- Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlands; Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands
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- Lovestone, Simon (författare)
- Department of Psychiatry, University of Oxford, Oxford, UK; Janssen‐Cilag UK Ltd, Oxford, UK
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- Legido-Quigley, Christina (författare)
- Steno Diabetes Center Copenhagen, Gentofte, Denmark; Institute of Pharmaceutical Science, King's College London, London, UK
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(creator_code:org_t)
- 2019-01
- 2019
- Engelska.
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Ingår i: Alzheimer’s & Dementia. - : John Wiley & Sons. - 2352-8737. ; 5:C, s. 933-938
- Relaterad länk:
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https://doi.org/10.1...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://gup.ub.gu.se...
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Abstract
Ämnesord
Stäng
- IntroductionMachine learning (ML) may harbor the potential to capture the metabolic complexity in Alzheimer Disease (AD). Here we set out to test the performance of metabolites in blood to categorize AD when compared to CSF biomarkers.MethodsThis study analyzed samples from 242 cognitively normal (CN) people and 115 with AD‐type dementia utilizing plasma metabolites (n = 883). Deep Learning (DL), Extreme Gradient Boosting (XGBoost) and Random Forest (RF) were used to differentiate AD from CN. These models were internally validated using Nested Cross Validation (NCV).ResultsOn the test data, DL produced the AUC of 0.85 (0.80–0.89), XGBoost produced 0.88 (0.86–0.89) and RF produced 0.85 (0.83–0.87). By comparison, CSF measures of amyloid, p‐tau and t‐tau (together with age and gender) produced with XGBoost the AUC values of 0.78, 0.83 and 0.87, respectively.DiscussionThis study showed that plasma metabolites have the potential to match the AUC of well‐established AD CSF biomarkers in a relatively small cohort. Further studies in independent cohorts are needed to validate whether this specific panel of blood metabolites can separate AD from controls, and how specific it is for AD as compared with other neurodegenerative disorders.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- EMIF‐AD
- Alzheimer's disease
- Metabolomics
- Biomarkers
- Machine‐Learning
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Stamate, Daniel
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Kim, Min
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Proitsi, Petroul ...
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Weestwood, Sarah
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Baird, Alison
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Nevado-Holgado, ...
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visa fler...
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Hye, Abdul
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Bos, Isabelle
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Vos, Stephanie J ...
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Vandenberghe, Ri ...
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Teunissen, Charl ...
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Kate, Mara Ten
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Scheltens, Phili ...
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Gabel, Silvy
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Meersmans, Karen
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Blin, Olivier
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Richardson, Jill
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De Roeck, Ellen
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Engelborghs, Seb ...
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Sleegers, Kriste ...
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Bordet, Régis
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Ramit, Lorena
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Kettunen, Petron ...
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Tsolaki, Magda
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Verhey, Frans
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Alcolea, Daniel
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Lléo, Alberto
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Peyratout, Gwemd ...
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Tainta, Mikael
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Johannsen, Peter
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Freund-Levi, Yvo ...
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Frölich, Lutz
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Dobricic, Valeri ...
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Frisoni, Giovann ...
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Molinuevo, José ...
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Wallin, Anders, ...
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Popp, Julius
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Martinez-Lage, P ...
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Bertram, Lars
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Blennow, Kaj, 19 ...
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Zetterberg, Henr ...
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Streffer, Johann ...
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Visser, Pieter J ...
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Lovestone, Simon
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Legido-Quigley, ...
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och Klinisk medicin
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och Geriatrik
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
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- MEDICIN OCH HÄLSOVETENSKAP
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Alzheimer’s & De ...
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Örebro universitet
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Karolinska Institutet
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Göteborgs universitet